Characterization of New Titanium Oxide Polymer Hybrid Membranes for Biofilm Formation

International audiencePresently, there is great need to create new matrices for diverse applications particularly in the fields of biotechnology and food industry. Here, we report on the synthesis of new matrices based on a mixture of polymer cellulose acetate butyrate/copolymer polyacrylonitrile acrylamide/TiO2. The characterization of the new matrices was performed using IR spectroscopy, QCM technology, and SEM. The tests revealed that when we use our polymers as carriers, there is a limit for the concentration of titanium of 5%. Further increasing of Ti concentration leads to precipitation processes. The QCM analyses show that a low concentration of Ti(OBu)4 does not influence the viscosity of the matrices obtained, but their elasticity changes significantly. The membranes obtained were successfully applied for biofilm formation of Yeast strain Saccharomyces cerevisiae

Investigation on the proliferation of Gram negative bacterial cells onto sol-gel carriers

International audienceThis work is related to the synthesis and characterization of new hybrid sol-gel materials. Several carriers based on poly (N-acryloylglycine) (NAGly) composed of poly (ethylene glycol) dimethacrylate (PEGDM) were prepared. The effectiveness of biofilms formation of bacterial strains Escherichia coli and Pseudomonas fluorescents on the matrices was investigated by biochemical methods. Two types of hybrid gels were synthesized based on PEGDM, 2-hydroxyethyl acrylate (HEA) and N-acryloxysuccinimide ester (NAS) with incorporation of inorganic precursors. The rheological properties of the gels and formed biofilms were investigated by quartz crystal microbalance (qCM). The experimental results demonstrated that the obtained matrices are appropriate for biofilms formatio

Synthesis of new hybrid cell penetrating peptides-medical drugs molecules

In 1988 the remarkable ability of a peptide to traverse a cell's plasma membrane independent of a membrane receptor was revealed. They cause changes in the membranes leading to their permeability. This type of peptide molecules is called cell penetrating peptides (CPP). One of these peptides is sweet arrow peptide (SAP). Herein, we report for the synthesis of four analogues of SAP. A new interesting strategy for synthesis of Asn and Gln containing peptides starting from Glu and Asp and using Rink amide resin was applied