Are there interactive effects of physiological and radiative forcing produced by increased CO2 concentration on changes of land hydrological cycle?

AbstractThree coupled climate–carbon cycle models including CESM (Community Earth System Model), CanEsm (the Canadian Centre for Climate Modelling and Analysis Earth System Model) and BCC (Beijing Climate Center Climate System Model) were used to estimate whether changes in land hydrological cycle responded to the interactive effects of CO2-physiological forcing and CO2-radiative forcing. No signs could be indicated that the interactive effects of CO2-physiological forcing and CO2-radiative forcing on the hydrological variables (e.g. precipitation, evapotranspiration and runoff) were detected at global and regional scales. For each model, increases in precipitation, evapotranspiration and runoff (e.g. 0.37, 0.18 and 0.25mm/year2) were simulated in response to CO2-radiative forcing (experiment M3). Decreases in precipitation and evapotranspiration (about −0.02 and −0.09mm/year2) were captured if the CO2 physiological effect was only accounted for (experiment M2). In this experiment, a reverse sign in runoff (the increase of 0.08mm/year2) in contrast to M3 is presented. All models simulated the same signs across Eastern Asia in response to the CO2 physiological forcing and radiative forcing: increases in precipitation and evapotranspiration only considering greenhouse effect; reductions in precipitation and evapotranspiration in response to CO2-physiological effect; and enhanced trends in runoff from all experiments. However, there was still a large uncertainty on the magnitude of the effect of transpiration on runoff (decreased transpiration accounting for 8% to 250% of the increased runoff) from the three models. Two models (CanEsm and BCC) attributed most of the increase in runoff to the decrease in transpiration if the CO2-physiological effect was only accounted for, whereas CESM exhibited that the decrease in transpiration could not totally explain the increase in runoff. The attribution of the CO2-physiological forcing to changes in stomatal conductance versus changes in vegetation structure (e.g. increased Leaf Area Index) is an issue to discuss, and among the three models, no agreement appeared

A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons

Botulinum neurotoxin (BoNT), a Category A biothreat agent, is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses. BoNT acts specifically by blocking neurotransmission primarily at peripheral nerve-muscle junctions causing severe flaccid muscle paralysis, which is fatal if proper medical care is not provided. The neurotoxin acts by specifically entering the presynaptic nerve endings where it interferes with the biochemical machinery involved in the process of neurotransmitter release, i.e., neuroexocytosis. Most serotypes of BoNT are known to remain active for weeks to months after entering the nerves, but BoNT/A is the most potent and long lasting in causing muscle paralysis. An effective medical countermeasure strategy requires developing a drug that could rescue poisoned neuromuscular synapses, and would include its efficient delivery specifically to presynaptic nerve terminals. Here we report rescuing of botulinum poisoned nerve cells by Mastoparan-7 (Mas-7), a peptide constituent of bee venom, that was delivered through a drug delivery vehicle (DDV) constructed from the non-toxic fragment of botulinum neurotoxin itself. We found that Mas-7 that was delivered into BoNT/A intoxicated cultured mouse spinal cord cells restored over 40% of stimulated neurotransmitter release. The rescue of the cell poisoning did not occur from inhibition of the endopeptidase activity of BoNT/A against its well known substrate, SNAP-25 that is mechanistically involved in the exocytosis process. Rather, Mas-7 induced a physiological host response apparently unrelated to SNAP-25, but linked to the phospholipase signal transduction pathway. In addition to providing the first effective antidote against botulism, our results open new avenues to study the mechanism of exocytosis, and also to examine an alternative cellular mechanism of botulinum neurotoxin action. An effective BoNT-based DDV can also be utilized for drug delivery against many neuronal and neuromuscular disorders

Multi-mode control based on HSIC for double pendulum robot

Double pendulum robot has four equilibrium points: Down-Down, Down-Up, Up-Down, and Up-Up. Define the transfer control from one equilibrium point to another equilibrium point as acrobatic action of DPR, and there are total of 20 acrobatic actions. This paper proposes the multi-mode control algorithm based on Human Simulated Intelligent Control theory for the realization process of those acrobatic actions, which has the structure of multi sub-controllers and multi control modes. As an example, the acrobatic action from Down-Up to Up-Down is realized in simulation and real-time experiments, and the results demonstrate the effectiveness of the proposed algorithm

Impact of climate variability and change on crime rates in Tangshan, China

Studies examining the relation between climate and human conflict often focus on the role of temperature and have diverging views on the significance of other climatic variables. Using a 6-year (from 2009 to 2014) dataset of crime statistics collected in a medium size city of Tangshan in China, we find strong, positive correlations between temperature and both violent and property crimes. In addition, relative humidity is also positively correlated with Rape and Minimal Violent Robbery (MVR). The seasonal cycle is a significant factor that induces good correlations between crime rates and climatic variables, which can be reasonably explained by the Routine Activity theory. We also show that the combined impacts of temperature and relative humidity on crime rates can be reasonably captured by traditional heat stress indices. Using an ensemble of CMIP5 global climate change simulations, we estimate that at the end of the 21st century the rates of Rape (violent crime) and MVR (property crime) in Tangshan will increase by 9.5 ± 5.3% and 2.6 ± 2.1%, respectively, under the highest emission scenario (Representative Concentration Pathway 8.5). The gross domestic product (GDP) is also shown to be significantly correlated with MVR rates and the regression results are strongly impacted by whether GDP is considered or not