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57 research outputs found

Evaluation of patients with a HeartMate 3 left ventricular assist device using echocardiographic particle image velocimetry

Author: Akin S. (Şakir)
Bowen D. (Dan)
Brugts J.J. (Jasper J.)
Caliskan K.C. (Kadir)
Constantinescu A.A. (Alina)
Manintveld O.C. (Olivier)
Muslem R. (Rahatullah)
Schinkel A.F.L. (Arend)
Strachinaru M. (Mihai)
Yalcin Y.C. (Yunus C.)
Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2020
Field of study

Purpose: Poor left ventricular (LV) function may affect the physiological intraventricular blood flow and physiological vortex formation. The aim of this study was to investigate the pattern of intraventricular blood flow dynamics in patients with LV assist devices (LVADs) using echocardiographic particle image velocimetry. Materials and methods: This prospective study included 17 patients (mean age 57 ± 11 years, 82% male) who had received an LVAD (HeartMate 3, Abbott Laboratories, Chicago, Illinois, USA) because of end-stage heart failure and poor LV function. Eleven (64%) patients had ischemic cardiomyopathy, and six patients (36%) had nonischemic cardiomyopathy. All patients underwent echocardiography, including intravenous administration of an ultrasound-enhancing agent (SonoVue, Bracco, Milan, Italy). Echocardiographic particle image velocimetry was used to quantify LV blood flow dynamics, including vortex formation (Hyperflow software, Tomtec imaging systems Gmbh, Unterschleissheim, Germany). Results: Contrast-enhanced ultrasound was well tolerated in all patients and was performed without adverse reactions or side effects. The LVAD function parameters did not change during or after the ultrasound examination. The LVAD flow was on average 4.3 ± 0.3 L/min, and the speed was 5247 ± 109 rotations/min. The quantification of LV intraventricular flow demonstrated substantial impairment of vortex parameters. The energy dissipation, vorticity, and kinetic energy fluctuation indices were severely impaired. Conclusions: Echo particle velocimetry is safe and feasible for the quantitative assessment of intraventricular flow in patients with an LVAD. The intraventricular LV flow and vortex parameters are severely impaired in these patients

Erasmus University Digital Repository

Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry

Author: A. L. R. Ng
Abardia Oliva F. J.
Abdel Malak S.
Abdel Wahab H.
Abdul Kareem B. B.
Abdul Manap H.
Abdul Rahim A. A.
Abdulkader F.
Abdulla A. H. K.
AbdulWahab M. Z.
Abduvalieva V.
Abele S.
Aboyans V.
Abreu P. E.
Adam-Blanpain M.
Adamaszek K.
Adamczyk-Kot D.
Adamkiewicz-Piejko A.
Adda M.
Aftab A.
Agrawal A.
Aguiar C.
Ahuad Guerrero A.
Ahuja R.
Ai F.
Aimouch N.
Aiyegbayo O.
Ajani A.
Akbar M.
Aksyutina N.
Al Dhanki M.
Al Ghool S.
Al Kandari F.
Al Lawati A.
Al Mahmeed W.
Al Radaideh G.
Al Rashdan I.
Al Sousi A.
Al Suwaidi J.
Al Tamimi F.
Al Wahshi Y.
Al Yazeedi J.
Al Zaibag M.
Al-Baker H.
Al-Faleh H.
Al-Hersi A.
Al-Khalidi B.
Al-Shamiri M.
Al-Zaibag M.
Alam A.
Alanazy M.
Alanbaei M.
Albero Martinez V.
Alberto Ramirez Reyes H.
Albuquerque A.
Alcaravela J.
Alcocer Gamba M.
Alegret Colomer J. M.
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Alekseenko V.
Alekseeva T.
Alexanderson E.
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Alvarez Aunon A.
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Publication venue: 'Public Library of Science (PLoS)'
Publication date: 01/01/2015
Field of study

Florence Research

Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial

Author: Abe Mitsunori
Abhaichand Rajpal K
Abhayaratna Walter P
Abhyankar Atul
Abidin Imran B Zainal
Abou Assi Hiba
Accini Mendoza Jose L
Adas Mine
Agaiby John M
Agarwal Devendra K
Agha Maher
Ahmed Azazuddin
Ahtiainen Petteri
Aigner Elmar
Ajay Naik
Al-Karadsheh Amer
Al-Zoebi Ayham
Ali Norsiah
Allison Dale C
Allison Roy
Alpenidze Diana
Altuntas Yuksel
Ambuj Roy
Amerena John
Anderson Robert J
Ando Toshiaki
Andrews Robert
Antonova Elizaveta
Appel Karl-Friedrich
Arantes Flávia B
Araz Mustafa
Arbel Yaron
Arenas León José L
Argyrakopoulou Georgia
Ariani Mehrdad
Arias Mendoza Maria A
Arif Ahmed A
Arneja Jaspal
Aroda Vanita R
Aronne Louis J
Arstall Margaret
Asamoah Njaimeh
Asanin Milika
Audish Hanid
Avram Rodica
Badat Aysha
Badiu Corin V
Bakdash Wa'el
Bakiner Okan S
Bandezi Vuyokazi N
Bang Liew H
Bansal Sandeep
Baranyai Marietta
Barbarash Olga
Barber Mark
Barnum Otis
Barone Rochette Gilles
Bashkin Amir
Baum Seth
Bays Harold E
Bazzoni Ruiz Alberto E
Beckowski Maciej
Beerachee Yaswin
Bellary Srikanth
Belousova Lidia
Berk Martin
Bernstein Marc
Berra Cesare
Beshay Isaac
Bhagwat Ajit
Bhan Arti
Biggs William C
Billings Liana
Bitar Fahed
Block Bradley
Bo Simona
Bogdanski Pawel
Bolshakova Olga O
Boshchenko Alla A
Bosworth Hayden
Botero Lopez Rodrigo
Bourgeois Ronald
Bôttcher Morten
Brautigam Donald
Breton Cristian F
Broadley Andrew
Brockmyre Andrew P
Brodie Steven K
Brown-Frandsen Kirstine
Bucci Marco
Budincevic Hrvoje
Budoff Matthew J
Buffman Barry
Buljubasic Nediljka
Buranapin Supawan
Burgess Lesley
Burguera Bartolomé
Buriakovska Olena
Buscemi Silvio
Busch Robert
Buse John B
Buynak Robert
Byrne Maria
Caceaune Elena
Cadena Bonfanti Alberto J
Calinescu Cornell V
Call Robert S
Canecki Varzic Silvija
Cannon Kevin
Capehorn Matt
Cariou Bertrand
Carr Jeffrey
Carrillo-Jimenez Rodolfo
Casas Marcelo
Castro Almudena
Celik Ahmet
Cercato Cintia
Cermak Ondrej
Cha James Y
Chacon Carolina
Chaicha-Brom Tira
Chandra Sandeep
Chettibi Mohamed
Chevts Julia
Christopher Johann
Chrustowski Witold
Cif Adriana
Clark Rebecca
Clark Wayne
Clifford Piers
Coetzee Kathleen
Cogni Giulia
Colao Anna Maria
Colhoun Helen M
Colhoun Helen M
Colquhoun David M
Concha Mauricio
Condit Jonathan
Constance Christian
Constantin Ciprian
Constantinescu Silviana
Corbett Clive
Cornett George M
Correia Marcelo
Cortinovis Fiorenzo
Cosma Dana
Creely Steven
Cross David
Curtis Brian
Czochra Wojciech
D'agostino Ronald
Daboul Nizar Y
Dagdelen Selcuk
Dang Cuong
Datta Sudip
Davuluri Ashwini K
Dawood Saleem Y
De Jong Douwe M
De La Cuesta Carmen
De Los Rios Ibarra Manuel O
De Pablo Carmen
De Pauw Michel
Deanfield John
Deanfield John E
Dela Llana Alexander
Delibasic Maja
Delic-Brkljacic Diana
Demicheli Thibaud
Denger Ralf J
Desai Devang
Desai Piyush
Desouza Cyrus V
Dicker Dror
Djenic Nemanja
Dobson Simon
Doi Masayuki
Doran Jesse A
Dorman Reinhart
Dotta Francesco
Dukes Carl E
Duronto Ernesto
Durst Ronen
Dvoryashina Irina V
Ebrahim Iftikhar O
Eggebrecht Holger
Egstrup Kenneth
Ekinci Elif I
Eliasson Björn
Eliasson Ken
Emerson Scott S
Emerson Scott S
Enache Georgiana
Enculescu Dan
English Patrick
Ermakova Polina
Ershova Olga
Ezaki Hirotaka
Ezhov Marat
Farias Eduardo
Farias Javier M
Farsky Pedro S
Ferreira Daniel
Filteau Pierre
Finneran Matthew P
Folkens Eric M
Fonseca Alberto G
Fonseca Luisa
Fordan Steven
Fourie Nyda
Franco Denise R
França Sara
Franek Edward
Frenkel Ofir
Friedman Keith
Frittitta Lucia
Froer Michael
Fuckar Krunoslav
Fujii Kenshi
Fujita Ryoko
Fukushima Yasushi
Fulat Mohamed
Fulwani Mahesh
Gajos Grzegorz
Galyavich Albert
Gambill Michael L
Gandotra Dheeraj
Garcia Hernandez Pedro A
García Reza Raymundo
Garg Naveen
Garg Sandeep
Garvey William T
Garza Juan C
Gatta-Cherifi Blandine
Gelev Valeri
Geller Steven A
Geohas Jeffrey G
Georgiev Borislav
Ghazi Adline
Gilbert Matthew P
Gilinskaya Olga
Gislason Gunnar
Gogas Yavuz Dilek
González Albarrán Olga
Gordeev Ivan G
Gorton Sidney C
Goudev Assen
Goudev Assen
Gretland Valderhaug Tone
Groenemeijer Bjorn
Gul Ibrahim
Gullestad Lars
Gurieva Irina
Guseva Galina N
Hagenow Andreas
Haluzik Martin
Halvorsen Sigrun
Hammoudi Naima
Hanaoka Keiichi
Hancu Nicolae
Hanusch Ursula
Hardt-Lindberg Soren
Hardt-Lindberg Søren
Harris Barry
Harris Kathleen
Hartleib Michael
Hartman Aaron N
Hata Yoshiki
Heimer Brian
Herman Lee
Herzog William
Hewitt Eric
Heymer Peter
Hiremath Shirish
Hjelmesaeth Joeran
Holmer Helene
Horoshko Olha
Houser Patricia M
Hove Jens D
Hovingh G Kees
Hovingh G Kees
Hsieh I-Chang
Hulot Jean-Sébastien
Hussein Zanariah
Høgalmen Rasmus Geir
Høivik Hans Olav
Ilashchuk Tetiana
Ilveskoski Erkki
Ipatko Irina
Iranmanesh Ali
Isawa Tsuyoshi
Issa Moises
Iteld Bruce
Iwasawa Takamasa
Jabbar Danish
Jackson Richard A
Jackson-Voyzey Ewart
Jacob Stephan
Jaffrani Naseem A
Jardula Michael F
Jastreboff Ania
Jensen Svend E
Jerkins Terri
Jimenez-Ramos Silvia A
Jitendra Pal Singh Sawhney
Johnson Wallace
Joyce John M
Jozefowska Malgorzata
Jugnundan Prakash
Jungmair Wolfgang
Jurowiecki Jaroslaw
Kadokami Toshiaki
Kahali Dhiman
Kahn Steven E
Kahn Steven E
Kahrmann Gerd
Kaiser Sergio E
Kalmucki Piotr
Kanadasi Mehmet
Kandath David
Kania Grzegorz
Kannan J
Kapp Cornelia
Karczmarczyk Agnieszka
Kartalis Athanasios
Kaser Susanne
Kasim Sazzli Shahlan
Kastelic Richard
Kato Toshiaki
Katova Tzvetana
Kaul Upendra
Kautzky-Willer Alexandra
Kawanishi Masahiro
Kayikcioglu Meral
Kazakova Elena E
Keeling Philip
Kempe Hans-Peter
Kereiakes Dean J
Kerneis Mathieu
Keski-Opas Tiina
Khadra Suhail
Khaisheva Larisa
Kharakhulakh Marina
Khlevchuk Tatiana
Khoo Jeffrey
Kiatchoosakun Songsak
Kinoshita Masaharu
Kinoshita Noriyuki
Kitamura Ryoji
Kiyosue Arihiro
Klavina Irina
Klein Eric J
Klimsa Zdenek
Klonoff David
Klug Eric
Kobalava Zhanna
Kodera Satoshi
Koga Tokushi
Kokkinos Alexander
Koleckar Pavel
Koren Michael J
Kormann Adrian P
Kosiborod Mikhail N
Kostner Karam
Könyves László
Kreutzmann Kristin
Krishinan Saravanan
Krishnasamy Sathya S
Krivosheeva Inga
Kruljac Ivan
Kubicki Ted
Kuchar Ladislav
Kujawiak Monika
Kunishige Hideyuki
Kurtinecz Melinda
Kurtz Lisboa Hugo R
Kushner Robert F
Kushnir Mykola
Kyyak Yulian
Lace Arija
Lakka Timo
Lalic Katarina
Lalic Nebojsa
Lambadiari Vaia
Lanaras Leonidas
Lang Chim
Lang Chim C
Langlois Marie-France
Lash Joseph
Latkovskis Gustavs
Lau David
Lazcano Soto José Roberto
Le Roux Carel
Ledesma Gilbert N
Lee Kelvin
Lee Li Yuan
Lee Thung-Lip
Lehrke Michael
Leite Silmara O
Leksycka Agata
Lenzmeier Thomas
Leonetti Frida
Leonidova Viktoriia
Lepor Norman
Leung Melissa
Levchenko Olena
Levins Peter
Levy Louis J
Lewis Matthew
Liberopoulos Evangelos
Liberty Idit
Lincoff A Michael
Lincoff A Michael
Lindholm Carl-Johan
Lingvay Ildiko
Lingvay Ildiko
Linhart Ales
Liu Jenny
Liu Ming-En
Lofton Holly
Logemann Timothy
Lombaard Johannes J
Lombard Landman
Lorraine Richard
Lovell Charles F
Ludvik Bernhard
Lukaszewicz Monika
Lupkovics Géza
Lupovitch Steven
Lupu Sirona
Lynch Mary
Lysak Zoreslava
Lysenko Tatyana A
Maeda Hajime
Maeda Itaru
Mahajan Ajay U
Maher Vincent
Maia Lilia N
Makotoko Ellen M
Malavazos Alexis
Malecha Jan
Malicherova Emilia
Manita Mamoru
Mannucci Edoardo
Mareev Viacheslav
Marin Liliana
Markova Tatiana
Marso Steven P
Martens F. M. A. C.
Martinez Cano Carlos A
Martinez Cuper
Martins Cristina
Masmiquel Comas Luis
Matsumoto Takashi
Mcdonald Kenneth
Mcgowan Barbara
Mcgrew Frank
Mclean Barry K
Mcpherson David D
Merino Torres Juan Francisco
Meyers Peter
Meyhöfer Sebastian
Mezquita Raya Pedro
Milanova Maria
Milicic Davor
Miller Gary
Mills Richard E
Mingrone Geltrude
Minkova Dotska A
Mirani Marco
Miras Alexander
Mistodie Cristina V
Mitomo Satoru
Mittal Sanjay
Miyake Taiji
Miyamoto Naomasa
Mîndrescu Nicoleta M
Molony David
Monteiro Pedro
Mooe Thomas
Moosa Naeem
Morales Portillo Cristobal
Morales Villegas Enrique C
Morawski Emily J
Morbey Claire
Morin Robert P
Morisaki Kuniaki
Morosanu Magdalena
Mosenzon Ofri
Mostovoy Yuriy
Munir Iqbal
Muratori Fabrizio
Murray Ryan
Murthy Avinash
Myint Min
Myshanych Galyna
Mæng Michael
Nafornita Valerica
Nagano Takuya
Nair Sunil
Nakhle Samer N
Natsuaki Masahiro
Nayak Bindu M
Nibouche Djamel Eddine
Nicholls Stephen
Nicolau José C
Nicolescu Georgiana
Nierop Peter
Niskanen Leo
Ntaios George
Nygård Ottar Kjell
O'donnell Philip
Oaks Joshua B
Obrezan Andrey
Oguri Mitsutoshi
Oguzhan Abdurrahman
Oh Fumiki
Ohsugi Mitsuru
Okada Yoshio
Okayama Hideki
Onaca Adriana
Onaka Haruhiko
Oneil Patrick
Ong Stephen
Ong Tiong Kiam
Ono Yasuhiro
Opsahl Paul J
Ostrowska Lucyna
Oviedo Alejandra
Ozdogan Oner
Ozpelit Ebru
Pagkalos Emmanouil
Pagotto Uberto
Pandey Amritanshu- Shekhar
Parkhomenko Oleksandr
Parvathareddy Krishna Malakondareddy
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Patsilinakos Sotirios
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Páll Dénes
Pedersen Sue
Pereira Edward Scott
Pereira Isabel
Perez Terns Paula
Perez-Vargas Elba A
Pergaeva Yulia
Perkelvald Alexander
Peskov Andrey B
Peter Jonathan
Peters Karina
Petit Catherine
Petrov Ivo
Philis-Tsimikas Athena
Pietilä Mikko
Pietilä Mikko
Pinto Fausto
Piros Annamária
Piyayotai Dilok
Platonov Dmitriy
Plutzky Jorge
Plutzky Jorge
Poirier Paul
Pop Lavinia
Pop-Busui Rodica
Popa Bogdan
Poremba John
Porto Alejandro
Postadzhiyan Arman
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Prafulla Kerkar G
Prager Rudolf
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Price Hermione
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Soyluk Selcukbiricik Ozlem
Spaic Tamara
Spriggs Douglas
Sreenan Seamus
St-Maurice Francois
Stahl Hans-Detlev
Stamatelopoulos Kimon
Stanislavchuk Mykola
Stankovic Goran
Stasek Josef
Steg Gabriel
Steindorf Joerg
Stephan Dominique
Stewart John
Still Christopher
Stogowska-Nikiciuk Barbara
Stoker Jeff
Stokic Edita
Strzelecka Anna
Sturm Kerstin
Sueyoshi Atsushi
Sugiura Toshiyuki
Sultan Senan
Suplotova Lyudmila A
Suwanagool Arisara
Suwanwalaikorn Sompongse
Sveklina Tatiana
Swanson Neil
Swart Henk
Swenson Bradley P
Szyprowska Ewa
Tait Graeme
Takács Róbert
Takeuchi Yuzo
Tamirisa Aparna
Tanaka Hideki
Tatovic Danijela
Tellier Guy
Teragawa Hiroki
Teterovska Dace
Thomas Nihal
Thuan Jean-Francois
Tinahones Francisco
Tisheva-Gospodinova Snezhanka
Toarba Cristina
Todoriuk Liudmyla
Tokmakova Mariya
Tonstad Serena
Toplak Hermann
Tornøe Christoffer W
Tran Henry
Tripathy Devjit
Trusau Aliaksandr
Tsabedze Nqoba
Tsougos Elias
Tsoukas George M
Tuccinardi Dario
Tuna Mazhar M
Turatti Luiz A
Tziomalos Konstantinos
Udommongkol Chesda
Ueda Osamu
Ukkola Olavi
Unubol Mustafa
Urbach Dorothea
Urina Triana Miguel A
Urina-Triana Miguel
Usdan Lisa
Vaidya Bijay
Vale Noah
Vallieres Gerald
Van Beek Andre P
Van De Borne Philippe
Van Der Walt Eugene
Van Der Zwaan C.
Van Nieuwenhuizen Elane
Van Zyl Louis
Vanduynhoven Philippe
Varghese Kiron
Vasileva Svetla P
Vassilev Dobrin
Vathesatogkit Prin
Velychko Valentyna
Vercammen Chris
Verges Bruno
Verma Subodh
Verma Subodh
Verwerft Jan
Vesela Alica
Veselovskaya Nadezhda G
Vettor Roberto
Veze Irina
Vijan Vinod
Vijayaraghavan Ram
Villarino Adriana
Vincent Royce
Vinogradova Oksana
Vishlitzky Victor
Vlad Adrian
Vladu Ionela Mihaela
Vo Anthony
Von Engelhardt Charlotte
Von Münchhausen Candy
Vorobyeva Olga
Vossenberg T.
Vrolix Mathias
Vukicevic Marjana
Vyshnyvetskyy Ivan
Wadvalla Shahid
Wagner Jan
Wakeling John
Wallace James
Wan Mohamed Wan Mohd Izani
Wander Gurpreet S
Ward Kathleen
Warren Mark L
Watanabe Atsuyuki
Weber Bruce
Weeke Peter E
Weintraub Howard
Weisnagel John
Welker James
Wendisch Ulrich
Wenocur Howard S
Wierum Craig
Wilding John
William Maged
Wilson Jonathan P
Wilson Pete
Winston Gandy
Wong Yuk-Ki
Wongcharoen Wanwarang
Wozniak Iwona
Wu Chau-Chung
Wyatt Nell
Wynne Alan
Yamaguchi Hiroshi
Yamasaki Masahiro
Yazici Dilek
Yeh Hung-I
Yotov Yoto
Yuan Qingyang
Zacher Jeffrey
Zagrebelnaya Olga
Zaidman Cesar J
Zalevskaya Alsu
Zarich Stuart
Zatelli Maria Chiara
Zeller Helga
Zhdanova Elena A
Zornitzki Taiba
Zrazhevskiy Konstantin
Zykov Mikhail
Publication venue
Publication date: 01/01/2024
Field of study

Background: Semaglutide, a GLP-1 receptor agonist, reduces the risk of major adverse cardiovascular events (MACE) in people with overweight or obesity, but the effects of this drug on outcomes in patients with atherosclerotic cardiovascular disease and heart failure are unknown. We report a prespecified analysis of the effect of once-weekly subcutaneous semaglutide 2·4 mg on ischaemic and heart failure cardiovascular outcomes. We aimed to investigate if semaglutide was beneficial in patients with atherosclerotic cardiovascular disease with a history of heart failure compared with placebo; if there was a difference in outcome in patients designated as having heart failure with preserved ejection fraction compared with heart failure with reduced ejection fraction; and if the efficacy and safety of semaglutide in patients with heart failure was related to baseline characteristics or subtype of heart failure. Methods: The SELECT trial was a randomised, double-blind, multicentre, placebo-controlled, event-driven phase 3 trial in 41 countries. Adults aged 45 years and older, with a BMI of 27 kg/m2 or greater and established cardiovascular disease were eligible for the study. Patients were randomly assigned (1:1) with a block size of four using an interactive web response system in a double-blind manner to escalating doses of once-weekly subcutaneous semaglutide over 16 weeks to a target dose of 2·4 mg, or placebo. In a prespecified analysis, we examined the effect of semaglutide compared with placebo in patients with and without a history of heart failure at enrolment, subclassified as heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, or unclassified heart failure. Endpoints comprised MACE (a composite of non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death); a composite heart failure outcome (cardiovascular death or hospitalisation or urgent hospital visit for heart failure); cardiovascular death; and all-cause death. The study is registered with ClinicalTrials.gov, NCT03574597. Findings: Between Oct 31, 2018, and March 31, 2021, 17 604 patients with a mean age of 61·6 years (SD 8·9) and a mean BMI of 33·4 kg/m2 (5·0) were randomly assigned to receive semaglutide (8803 [50·0%] patients) or placebo (8801 [50·0%] patients). 4286 (24·3%) of 17 604 patients had a history of investigator-defined heart failure at enrolment: 2273 (53·0%) of 4286 patients had heart failure with preserved ejection fraction, 1347 (31·4%) had heart failure with reduced ejection fraction, and 666 (15·5%) had unclassified heart failure. Baseline characteristics were similar between patients with and without heart failure. Patients with heart failure had a higher incidence of clinical events. Semaglutide improved all outcome measures in patients with heart failure at random assignment compared with those without heart failure (hazard ratio [HR] 0·72, 95% CI 0·60-0·87 for MACE; 0·79, 0·64-0·98 for the heart failure composite endpoint; 0·76, 0·59-0·97 for cardiovascular death; and 0·81, 0·66-1·00 for all-cause death; all pinteraction>0·19). Treatment with semaglutide resulted in improved outcomes in both the heart failure with reduced ejection fraction (HR 0·65, 95% CI 0·49-0·87 for MACE; 0·79, 0·58-1·08 for the composite heart failure endpoint) and heart failure with preserved ejection fraction groups (0·69, 0·51-0·91 for MACE; 0·75, 0·52-1·07 for the composite heart failure endpoint), although patients with heart failure with reduced ejection fraction had higher absolute event rates than those with heart failure with preserved ejection fraction. For MACE and the heart failure composite, there were no significant differences in benefits across baseline age, sex, BMI, New York Heart Association status, and diuretic use. Serious adverse events were less frequent with semaglutide versus placebo, regardless of heart failure subtype. Interpretation: In patients with atherosclerotic cardiovascular diease and overweight or obesity, treatment with semaglutide 2·4 mg reduced MACE and composite heart failure endpoints compared with placebo in those with and without clinical heart failure, regardless of heart failure subtype. Our findings could facilitate prescribing and result in improved clinical outcomes for this patient group. Funding: Novo Nordisk

Archivio della Ricerca - Università degli Studi di Siena

Transition, Integration and Convergence. The Case of Romania

Author: * Dans Ce Contexte
-I-Martin Sala
A Fuera
A Hannequart
A Iancu
A Iancu
A L Hillman
A P Thirlwall
Aghion Pilippe
Ahsan
Ahsan
Allen David
Andrew Murphie
Arvind Subramanian
Aurel Iancu
Aurel Iancu
Aurel Iancu
Aurel Iancu
Aurel Iancu
Aurel Iancu
B Balassa
B Commoner
B Commoner
B Fritsch
Barrie Stevens
Barrie Stevens
Barro Robert
Barro Robert
Bassanini Andrea
Breuss Fritz
C Ciupagea
C Mih?ileanu
Ciupagea C-Tin
Competitivitatea ?i Integrarea �n Uniunea
D Gabor
D Gabor
D Gabor
D Gabor
D Garcia
D Hudson
D Jorgensen
D Meadows
D Meadows
D?ianu Dan
Dalgaard Carl-Johan
Daniel Kaufman
Daniel Piazolo
Douglas C North
Durlauf N St
Edwards
Edwards Sebastian
Edwards Sebastian
Eli Heckscher
Esteban Joan-Maria
Fugaru Amalia
G H Jefferson
G Mankiw
G Myrdal
G Myrdal
Geraldine Schmidt
Gilberto Sarfati
Gole? Br�ndeu Octavian
H Bourguinat
H Henderson
H N Mccarl
H Schmieding
Harry Shutt
Herbert Giersch
I Singh
Idu Pompilia
Is?rescu Mugur
Ivar Foss
J Coleman
J E Anderson
J Forrester
J Frait
J Gressor
J Griffin
J Montias
J Teece
J Vanek
Jagdish Bhagwati
James Harrigan
Jeffrey S Sachs
John H Dunning
Jones Charles
Jovanovi? Miroslav
Julia S O&quot
Justin Lin
K Boulding
K E Schenk
K J Arrow
K W Kapp
Krugman Paul
Kutan Ali
L A Metzler
L Halpern
L Schipper
Lauren?iu Cioc�rlan
Lavra? Vladimir
Los Bart
Lu?as Mihaela
Lucas Robert
Ludger Schuknecht
M Abramovitz
M Altar
M D Goldberg
M E Sharpe
M Mesarovi?
M Mesarovi?
M Olson
M Saleh
M Taylor Alan
Manoilescu Mihai
Manoilescu Mihai
Martin Raiser
Martin Reiner
Matkowski Zbigniew
Matkowski Zbigniew
Mauro Paolo
Mcarthur Mark
Mckenizie Richard
Meeusen Wim
Meeusen Wim
Melo Marcus
Michael E Porter
Michael E Porter
Michalski Wolfgang
Michalski Wolfgang
Mih?escu Flavius
Mih?escu Flavius
Mih?ilescu Al
Milanovi? Branco
Mohapatra Sarita
Mohapatra Sarita
Molle Stefano
Moore Chris
Morissens Lucien
Muller-Armack Alfred
Murphie Andrew
Musgrave Richard
N Georgesccu-Roegen
N Georgescu-Roegen
N Georgeseu-Roegen
N N Constantinescu
Nauro F Campos
Oleh Havrylyshyn
Oleh Havrylyshyn
P Ehrlich
P Fudulu
P Samuelson
P Samuelson
Pavel Pelikan
Pelkmans Jacques
Pelkmans Jacques
Perroux Fr
Perroux Fr
Petre Prisecaru
Pierre Garello
Pilat Vasile
Probleme Ince
Probleme Ince
Puga Diego
Quin Rene
R Ayres
R C O Matthews
R C O Matthews
R Czech
R Dornbusch
R Prebisch
R W Jones
R W Jones
R W Sant
R Yarger
R?doi
R?doi
Ranis Gustav
Redding Stephen
Reiner Martin
Renzo Davidi
Richart R Nelson
Robert E Hall
Robert E Hall
Rogoff Kenneth
Romer Paul
Romer Paul
Salater Wilhelm
Salater Wilhelm
Sarfati Gilberto
Savastano Miguel
Scarpeta Stefano
Schipper Lee
Schnabl De Grauwe Paul
Schnabl Gunther
Schuknecht Ludger
Schularick Moritz
Schumpeter Joshep
Seiji Naya
Sheehy John
Shinichi Ichimura
Shutt Harry
Simon Herbert
Smith Adam
Soete Luc
Soete Luc
Solow Robert
Solow Robert
Stefano Molle
Stewart Frances
T Bayoumi
T H Jarrett
T H Jarrett
T N Srinivasan
T W Schultz
Truger Hein Eckhard
Tudorel Postolache
Valentin Cojanu
Vernon Raymond
Von Hagen
W Beckerman
W Heller
W Leontief
W Sassin
W Van Gool
W W Leontief
W Weisskopf
Wallace Helen
Wallace Helen
Weinhold Diana
W�jcik Mac Donald Roland
Yifu Lin Justin
Yoshitomi Masaru
Zipfel Jacob
�gert Babetskii Jan
�gert Bal�zs
�gert Bal�zs
Publication venue: 'Elsevier BV'
Publication date: 01/01/2010
Field of study

This volume comprises several studies and papers published in the last decades. They have been selected and ranged so that to provide a minimum of coherence concerning the phases which Romania has crossed in her way to the advanced socio-economic system of European type: transition to the market economy, accession to the EU, the economic convergence in the three fundamental domains: institutions, real economy, and nominal economy. The readers may find in this volume a description of debates, difficulties and solutions adopted for building-up the market economy by a state being in a profound transformation from weak transition institutions towards hard democratic institutions. Because the transition to the market economy and the association of Romania with the EU and then the integration presenting strategic political decisions, I have included in this work two studies devoted to the political forces state and political parties that elaborated and applied these strategic decisions underlining their structure, role and function and their transformation. Integration into the EU of a country like Romania, which emerged from a different system comparing with the West-European one, has proved to be difficult and lasting many years because of the structural transformations. In five chapters I am referring to the essential characteristics of the integration process, such as: market liberalization, competitiveness of the local (national) firms on the national and EU markets, institutional reforms so that the institutions of candidate countries have to become compatible with those of the EU and finally the perspective assessment to find out the real and nominal convergence. Putting into practice the EU competitivity and cohesion principles, Romania has good prospects to close, in a reasonable time, the economic gap and to be admitted into the Euro Zone. Although the real convergence of Romania with the EU requires higher growth rates for the former, a new approach is compulsory to take into consideration the environment quality, the natural resources and the equity between the present and the future generations as natural resource consumers. Just these problems have determined me to include in this volume the last two chapters which, on the one hand, try to prove the necessity of the economy growth harmonization with the environment evolution as well as the saving of the energy resources, and, on the other hand, to point out the main ways to be followed and instruments to be used

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EconStor (ZBW Kiel)