Analysis of the effects of overexpression of metallothionein-I in transgenic mice on the reproductive toxicology of cadmium.

Exposure to low levels of cadmium reduces fertility. In male mice spermatogenesis is highly sensitive to cadmium, whereas in females the peri-implantation period of pregnancy is sensitive. To examine the potential roles of the cadmium-binding protein, metallothionein (MT), in the reproductive toxicology of cadmium, we examined a transgenic mouse strain that overexpresses metallothionein-I (MT-I). These mice had dramatically increased steady-state levels of MT-I mRNA and MT in the testes and in the female reproductive tract during the peri-implantation period of pregnancy, and this overexpression occurred in a cell-specific and temporally regulated manner similar to that of the endogenous MT-I gene. Transgenic and control males were injected with cadmium, and the histology of the testes was examined. An injection of 7.5 mumol Cd/kg had no effect on histology of the testes in either transgenic or control mice. In contrast, an injection of 10 mumol Cd/kg caused rapid changes in the histology of the testes and resulted in pronounced testicular necrosis in both control and transgenic mice. Female transgenic and control mice were mated and then injected with cadmium (30-45 mumol Cd/kg) on the day of blastocyst implantation (day 4). In both of these groups, injection of cadmium reduced pregnancy rate, and no dramatic protection was afforded by maternal and/or embryonic overexpression of MT. Thus, overexpression of MT-I does not significantly protect against either of these cadmium-induced effects on fertility

Hierarchical clustering and formation of power-law correlation in 1-dimensional self-gravitating system

The process of formation of fractal structure in one-dimensional self-gravitating system is examined numerically. It is clarified that structures created in small spatial scale grow up to larger scale through clustering of clusters, and form power-law correlation.Comment: 9pages,4figure

Microjansky radio sources in DC0107-46 (Abell 2877)

The cluster DC0107-46 (Abell 2877) lies within the Phoenix Deep Survey, made at 1.4 GHz with the Australia Telescope Compact Array. Of 89 known optical cluster members, 70 lie within the radio survey area. Of these 70 galaxies, 15 (21%) are detected, with luminosities as faint as 10^20 W/Hz. Spectroscopic observations are available for 14/15 of the radio-detected cluster galaxies. Six galaxies show only absorption features and are typical low-luminosity AGN radio sources. One galaxy hosts a Seyfert 2 nucleus, two are star-forming galaxies, and the remaining five may be star-forming galaxies, AGNs, or both.Comment: 14 pages, 3 figures, Accepted by ApJS (v128n2p JUN 2000 issue

Foreword to APPG Policy Report: The Missing Link: HIV and mental health

Cite as: APPG on HIV and Aids (2020) APPG Policy Report: The Missing Link: HIV and mental health

Theory of Pseudomodes in Quantum Optical Processes

This paper deals with non-Markovian behaviour in atomic systems coupled to a structured reservoir of quantum EM field modes, with particular relevance to atoms interacting with the field in high Q cavities or photonic band gap materials. In cases such as the former, we show that the pseudo mode theory for single quantum reservoir excitations can be obtained by applying the Fano diagonalisation method to a system in which the atomic transitions are coupled to a discrete set of (cavity) quasimodes, which in turn are coupled to a continuum set of (external) quasimodes with slowly varying coupling constants and continuum mode density. Each pseudomode can be identified with a discrete quasimode, which gives structure to the actual reservoir of true modes via the expressions for the equivalent atom-true mode coupling constants. The quasimode theory enables cases of multiple excitation of the reservoir to now be treated via Markovian master equations for the atom-discrete quasimode system. Applications of the theory to one, two and many discrete quasimodes are made. For a simple photonic band gap model, where the reservoir structure is associated with the true mode density rather than the coupling constants, the single quantum excitation case appears to be equivalent to a case with two discrete quasimodes

The Aquarius Superclusters - I. Identification of Clusters and Superclusters

We study the distribution of galaxies and galaxy clusters in a 10^deg x 6^deg field in the Aquarius region. In addition to 63 clusters in the literature, we have found 39 new candidate clusters using a matched-filter technique and a counts-in-cells analysis. From redshift measurements of galaxies in the direction of these cluster candidates, we present new mean redshifts for 31 previously unobserved clusters, while improved mean redshifts are presented for 35 other systems. About 45% of the projected density enhancements are due to the superposition of clusters and/or groups of galaxies along the line of sight, but we could confirm for 72% of the cases that the candidates are real physical associations similar to the ones classified as rich galaxy clusters. On the other hand, the contamination due to galaxies not belonging to any concentration or located only in small groups along the line of sight is ~ 10%. Using a percolation radius of 10 h^{-1} Mpc (spatial density contrast of about 10), we detect two superclusters of galaxies in Aquarius, at z = 0.086 and at z = 0.112, respectively with 5 and 14 clusters. The latter supercluster may represent a space overdensity of about 160 times the average cluster density as measured from the Abell et al. (1989) cluster catalog, and is possibly connected to a 40 h^{-1} Mpc filament from z ~ 0.11 to 0.14.Comment: LateX text (21 pages) and 12 (ps/eps/gif) figures; figures 5a, 5b and 6 are not included in the main LateX text; to be published in the Astronomical Journal, March issu

Where Nanophotonics and Microfluidics Meet

A new generation of photonic devices has recently emerged that relies on using geometries of sub-wavelength microstructures within a high refractive index contrast materials system. These geometries are used to confine and manipulate light within very small volumes. High optical field densities can be obtained within such structures, and these in turn can amplify optical nonlinearities. Moreover, many of these structures, as for example photonic crystals and slotted waveguides, can be engineered for the efficient localization of light within the low-index regions of high index contrast microstructures. When such structures are back-filled nonlinear polymers or liquids, devices can be tuned and novel phenomena can be observed. In particular, such devices are very interesting when constructed from silicon on insulator (SOI) material in which the optical waveguide also serves as a transparent electrical contact. Here we show examples of the design, fabrication and testing of optical microstructures in which the electro-optic (χ2) and photorefractive (χ3) nonlinearities are used for electro-optic tuning, frequency mixing, optical rectification, and high-speed switching of light

Interaction of the quantized electromagnetic field with atoms in the presence of dispersing and absorbing dielectric bodies

A general theory of the interaction of the quantized electromagnetic field with atoms in the presence of dispersing and absorbing dielectric bodies of given Kramers--Kronig consistent permittivities is developed. It is based on a source-quantity representation of the electromagnetic field, in which the electromagnetic-field operators are expressed in terms of a continuous set of fundamental bosonic fields via the Green tensor of the classical problem. Introducing scalar and vector potentials, the formalism is extended in order to include in the theory the interaction of the quantized electromagnetic field with additional atoms. Both the minimal-coupling scheme and the multipolar-coupling scheme are considered. The theory replaces the standard concept of mode decomposition which fails for complex permittivities. It enables us to treat the effects of dispersion and absorption in a consistent way and to give a unified approach to the atom-field interaction, without any restriction to a particular interaction regime in a particular frequency range. All relevant information about the dielectric bodies such as form and intrinsic dispersion and absorption is contained in the Green tensor. The application of the theory to the spontaneous decay of an excited atom in the presence of dispersing and absorbing bodies is addressed.Comment: Paper presented at the International Conference on Quantum Optics and VIII Seminar on Quantum Optics, Raubichi, Belarus, May 28-31, 2000, 14 pages, LaTeX2e, no figure