Formulation induces direct DNA UV-A photooxidation. Part II. Pro-oxidant effect of formulated Vitamin E via generation of singlet oxygen

International audienceHIGHLIGHTS · Cetyltriethylammonium bromide (CTEAB) and Vitamin E self-assemble in TRIS/HCl buffer solutions into nanoemulsion composed of CTEAB micelles (that can incorporate Vitamin E) as well as larger Vitamin E droplets. · CTEAB-Vitamin E nanoemulsion interacts with plasmid DNA pBR322 and the gradual DNA compaction followed by gradual DNA decompaction for increasing CTEAB-Vitamin E amounts have been highlighted. · UVA irradiation induces photooxidation of DNA on the formulated CTEAB-Vitamin E-DNA lipoplex and underlines the pro-oxidant role of the Vitamin E in this self-assembled system

Formulation induces direct DNA UVA photooxidation. Part I. Role of the formulating cationic surfactant

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