Travelling waves in wound healing

We illustrate the role of travelling waves in wound healing by considering three different cases. Firstly, we review a model for surface wound healing in the cornea and focus on the speed of healing as a function of the application of growth factors. Secondly, we present a model for scar tissue formation in deep wounds and focus on the role of key chemicals in determining the quality of healing. Thirdly, we propose a model for excessive healing disorders and investigate how abnormal healing may be controlled

Ionisation-induced star formation II: External irradiation of a turbulent molecular cloud

In this paper, we examine numerically the difference between triggered and revealed star formation. We present Smoothed Particle Hydrodynamics (SPH) simulations of the impact on a turbulent 10^4 solar-mass molecular cloud of irradiation by an external source of ionising photons. In particular, using a control model, we investigate the triggering of star formation within the cloud. We find that, although feedback has a dramatic effect on the morphology of our model cloud, its impact on star formation is relatively minor. We show that external irradiation has both positive and negative effects, accelerating the formation of some objects, delaying the formation of others, and inducing the formation of some that would not otherwise have formed. Overall, the calculation in which feedback is included forms nearly twice as many objects over a period of \sim0.5 freefall times (\sim2.4 Myr), resulting in a star--formation efficiency approximately one third higher (\sim4% as opposed to \sim3% at this epoch) as in the control run in which feedback is absent. Unfortunately, there appear to be no observable characteristics which could be used to differentiate objects whose formation was triggered from those which were forming anyway and which were simply revealed by the effects of radiation, although this could be an effect of poor statistics.Comment: 12 pages, 9 figures, accepted by MNRA

Timescales for the development of methanogenesis and free gas layers in recently-deposited sediments of Arkona Basin (Baltic Sea)

Arkona Basin (southwestern Baltic Sea) is a seasonally-hypoxic basin characterized by the presence of free methane gas in its youngest organic-rich muddy stratum. Through the use of reactive transport models, this study tracks the development of the methane geochemistry in Arkona Basin as this muddy sediment became deposited during the last 8 kyr. Four cores are modeled each pertaining to a unique geochemical scenario according to their respective contemporary geochemical profiles. Ultimately the thickness of the muddy sediment and the flux of particulate organic carbon are crucial in determining the advent of both methanogenesis and free methane gas, the timescales over which methanogenesis takes over as a dominant reaction pathway for organic matter degradation, and the timescales required for free methane gas to form

Oral health awareness and care preferences in patients with diabetes : a qualitative study

Background People with type 2 diabetes have an increased risk of oral health problems; however, oral health is currently not included in structured diabetes reviews and education in the UK. Aim and Objectives This study explores the patient experience related to oral health and diabetes, especially in relation to: • Awareness of the link between oral health and diabetes and oral self care needs • Interaction with health professionals in dental and general practice • Preferences for receiving oral health information and education Methods This nested qualitative study involved semi-structured telephone interviews with a purposive sample of 20 participants from a questionnaire study on oral health awareness in patients with diabetes. Interview transcripts were analysed using a thematic framework approach. Results Participants were mostly unaware of the link between oral health and diabetes. Those that had been made aware by a health professional were not given concrete self care advice. Interactions with dental professionals were often limited to informing the dental practice of their diagnosis and current medication. Most participants were in favour of dentists screening for diabetes, but as their general practice was the hub for diabetes care, they felt GPs or nurses should provide oral health information and discuss oral health with patients. Conclusions Written information regarding diabetes and its possible effects on oral health needs to be more readily available to people with diabetes, especially at diagnosis. There may be a place for introducing a structured oral health question in routine diabetes reviews

Signatures of Galaxy-Cluster Interactions: Tully-Fisher Observations at z~0.1

We have obtained new optical imaging and spectroscopic observations of 78 galaxies in the fields of the rich clusters Abell 1413 (z = 0.14), Abell 2218 (z = 0.18) and Abell 2670 (z = 0.08). We have detected line emission from 25 cluster galaxies plus an additional six galaxies in the foreground and background, a much lower success rate than what was found (65%) for a sample of 52 lower-richness Abell clusters in the range 0.02 < z < 0.08. We have combined these data with our previous observations of Abell 2029 and Abell 2295 (both at z = 0.08), which yields a sample of 156 galaxies. We evaluate several parameters as a function of cluster environment: Tully-Fisher residuals, H-alpha equivalent width, and rotation curve asymmetry, shape and extent. Although H-alpha is more easily detectable in galaxies that are located further from the cluster cores, we fail to detect a correlation between H-alpha extent and galaxy location in those where it is detected, again in contrast with what is found in the clusters of lesser richness. We fail to detect any statistically significant trends for the other parameters in this study. The zero-point in the z~0.1 Tully-Fisher relation is marginally fainter (by 1.5 sigma) than that found in nearby clusters, but the scatter is essentially unchanged.Comment: 27 pages including 5 figures; accepted for publication in the Astronomical Journa

Disc Clearing of Young Stellar Objects: Evidence for Fast Inside-out Dispersal

The time-scale over which and the modality by which young stellar objects (YSOs) disperse their circumstellar discs dramatically influences the eventual formation and evolution of planetary systems. By means of extensive radiative transfer (RT) modelling, we have developed a new set of diagnostic diagrams in the infrared colour-colour plane (K-[24] vs. K-[8]), to aid with the classification of the evolutionary stage of YSOs from photometric observations. Our diagrams allow the differentiation of sources with unevolved (primordial) discs from those evolving according to different clearing scenarios (e.g. homologous depletion vs. inside-out dispersal), as well as from sources that have already lost their disc. Classification of over 1500 sources in 15 nearby star-forming regions reveals that approximately 39 % of the sources lie in the primordial disc region, whereas between 31 % and 32 % disperse from the inside-out and up to 22 % of the sources have already lost their disc. Less than 2 % of the objects in our sample lie in the homogeneous draining regime. Time-scales for the transition phase are estimated to be typically a few 10^5 years independent of stellar mass. Therefore, regardless of spectral type, we conclude that currently available infrared photometric surveys point to fast (of order 10 % of the global disc lifetime) inside-out clearing as the preferred mode of disc dispersal.Comment: 31 pages, 21 figures, 6 tables, accepted for publication in MNRA

Critical care provision after colorectal cancer surgery

Background: Colorectal cancer (CRC) is the 2nd largest cause of cancer related mortality in the UK with 40 000 new patients being diagnosed each year. Complications of CRC surgery can occur in the perioperative period that leads to the requirement of organ support. The aim of this study was to identify pre-operative risk factors that increased the likelihood of this occurring. Methods: This is a retrospective observational study of all 6441 patients who underwent colorectal cancer surgery within the West of Scotland Region between 2005 and 2011. Logistic regression was employed to determine factors associated with receiving postoperative organ support. Results: A total of 610 (9 %) patients received organ support. Multivariate analysis identified age ≥65, male gender, emergency surgery, social deprivation, heart failure and type II diabetes as being independently associated with organ support postoperatively. After adjusting for demographic and clinical factors, patients with metastatic disease appeared less likely to receive organ support (p = 0.012). Conclusions: Nearly one in ten patients undergoing CRC surgery receive organ support in the post operative period. We identified several risk factors which increase the likelihood of receiving organ support post operatively. This is relevant when consenting patients about the risks of CRC surgery

Autonomous rendezvous and docking: A commercial approach to on-orbit technology validation

The Space Automation and Robotics Center (SpARC), a NASA-sponsored Center for the Commercial Development of Space (CCDS), in conjunction with its corporate affiliates, is planning an on-orbit validation of autonomous rendezvous and docking (ARD) technology. The emphasis in this program is to utilize existing technology and commercially available components whenever possible. The primary subsystems that will be validated by this demonstration include GPS receivers for navigation, a video-based sensor for proximity operations, a fluid connector mechanism to demonstrate fluid resupply capability, and a compliant, single-point docking mechanism. The focus for this initial experiment will be expendable launch vehicle (ELV) based and will make use of two residual Commercial Experiment Transporter (COMET) service modules. The first COMET spacecraft will be launched in late 1992 and will serve as the target vehicle. The ARD demonstration will take place in late 1994, after the second COMET spacecraft has been launched. The service module from the second COMET will serve as the chase vehicle

The dynamics of single spike-evoked adenosine release in the cerebellum

The purine adenosine is a potent neuromodulator in the brain, with roles in a number of diverse physiological and pathological processes. Modulators such as adenosine are difficult to study as once released they have a diffuse action (which can affect many neurones) and, unlike classical neurotransmitters, have no inotropic receptors. Thus rapid postsynaptic currents (PSCs) mediated by adenosine (equivalent to mPSCs) are not available for study. As a result the mechanisms and properties of adenosine release still remain relatively unclear. We have studied adenosine release evoked by stimulating the parallel fibres in the cerebellum. Using adenosine biosensors combined with deconvolution analysis and mathematical modelling, we have characterised the release dynamics and diffusion of adenosine in unprecedented detail. By partially blocking K+ channels, we were able to release adenosine in response to a single stimulus rather than a train of stimuli. This allowed reliable sub-second release of reproducible quantities of adenosine with stereotypic concentration waveforms that agreed well with predictions of a mathematical model of purine diffusion. We found no evidence for ATP release and thus suggest that adenosine is directly released in response to parallel fibre firing and does not arise from extracellular ATP metabolism. Adenosine release events showed novel short-term dynamics, including facilitated release with paired stimuli at millisecond stimulation intervals but depletion-recovery dynamics with paired stimuli delivered over minute time scales. These results demonstrate rich dynamics for adenosine release that are placed, for the first time, on a quantitative footing and show strong similarity with vesicular exocytosis