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    CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling

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    5-HT2 and corticotrophin releasing factor (CRF) receptors both regulate stress responses and anxiety behavior; however, potential cross-talk between the two pathways is poorly understood. Magalhaes et al. find that CRF receptor activation causes cell-surface recruitment of constitutively internalized 5-HT2 receptor and that this mechanism is relevant to anxiety-related behaviors
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