The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits

Safflower yellow (SY) is the safflower extract and is the one of traditional Chinese medicine. The aim of the present work was to investigate the effect of SY on spinal cord ischemia reperfusion injury (SCIRI) in rabbits. The models of spinal cord ischemia reperfusion (SI/R) were constructed, and the degree of the post-ischemic injury was assessed by means of the neurological deficit scores and plasma levels of lipid peroxidation reactioin and neuronal morphologic changes. SCIRI remarkably affected the functional activities of the hind limbs and activated lipid peroxidation reaction. SY could attenuate apoptosis and SCIRI by enhancing Bcl-2 expression and inhibiting Bax and caspase-3 activation

Intravenous Infusion of Dexmedetomidine Combined Isoflurane Inhalation Reduces Oxidative Stress and Potentiates Hypoxia Pulmonary Vasoconstriction during One-Lung Ventilation in Patients

Inhalation anesthetic isoflurane inhibits hypoxia pulmonary vasoconstriction (HPV), while dexmedetomidine (Dex) could reduce the dose of isoflurane inhalation and potentiate HPV, but the mechanism is unclear. Inhibition of reactive oxygen species (ROS) production can favor HPV during one-lung ventilation (OLV). Similarly, nitric oxide (NO), an important endothelium-derived vasodilator in lung circulation, can decrease the regional pulmonary vascular resistance of ventilated lung and reduce intrapulmonary shunting. We hypothesized that Dex may augment HPV and improve oxygenation during OLV through inhibiting oxidative stress and increasing NO release. Patients undergoing OLV during elective thoracic surgery were randomly allocated to either isoflurane + saline (NISO, n=24) or isoflurane + dexmedetomidine (DISO, n=25) group. Anesthesia was maintained with intravenous remifentanil and inhalational isoflurane (1.0–2.0%), with concomitant infusion of dexmedetomidine 0.7 μgkg−1h−1 in DISO and saline 0.25 mL kg−1h−1 in NISO group. Hemodynamic variables or depth of anesthesia did not significantly differ between groups. Administration of Dex significantly reduced Qs/Qt and increased PaO2 after OLV, accompanied with reduced lipid peroxidation product malondialdehyde and higher levels of SOD activity as well as serum NO (all P<0.05 DISO versus NISO). In conclusion, reducing oxidative stress and increasing NO release during OLV may represent a mechanism whereby Dex potentiates HPV

Carbon neutrality and clean air acts can enable China to meet the Minamata Convention goals with substantial cost savings

China faces the concurrent challenges of carbon dioxide (CO2) and toxic mercury (Hg) emissions from coal combustion, with implications for environmental and human health. To address these problems, China has implemented carbon neutrality targets and air pollution controls and signed the Minamata Convention. However, how to best leverage these measures for optimal outcomes (i.e., effectively reduce emissions and pollution with the least cost) remains elusive. Here we examined the best-practice portfolio of climate, air pollution, and Hg reduction policies via an energy-environment-economic integrated assessment model. We found that the most cost-effective solution to simultaneously address these issues is coupling carbon neutrality strategies with clean air policies, which can further save 384 million Chinese yuan (CNY) in Hg abatement in 2060. Furthermore, carbon neutrality measures alone can achieve near-zero Hg emissions, whereas Hg policies will only achieve about one-third of the carbon neutrality target. These findings provide practical lessons to cost-effectively address multiple climate and pollution issues, especially for emerging economies that face similar challenges