Ab Initio QM/MM Molecular Dynamics Study on the Excited-State Hydrogen Transfer of 7-Azaindole in Water Solution

Ab initio molecular dynamics (AIMD) simulations for the excited-state hydrogen transfer (ESHT) reaction of 7-azaindole (7AI−(H2O)n; n = 1, 2) clusters in the gas phase and in water are presented. The effective fragment potential (EFP) is employed to model the surrounding water molecules. The AIMD simulations for 7AI−H2O and 7AI−(H2O)2 clusters show an asynchronous hydrogen transfer at t ∼ 50 fs after the photoexcitation. While the ESHT mechanism for 7AI−H2O in water does not change appreciably compared with that in the gas phase, the AIMD simulations on 7AI−(H2O)2 in water solution exhibit two different mechanisms. Since the tautomer form is lower in energy compared to the normal form in the S1 state, 7AI and (H2O)n fragments separate from each other after the ESHT. With the use of the results of the AIMD trajectories, the minimum energy conical intersection point in the tautomer region has also been located

Physiological Markers of Motor Improvement Following Five-month Sprint Training in Young Boys

The 11th International Symposium on Adaptive Motion of Animals and Machines. Kobe University, Japan. 2023-06-06/09. Adaptive Motion of Animals and Machines Organizing Committee.Poster Session P4

Prognosis of Elderly Japanese Patients Aged ≥80 Years Undergoing Hemodialysis

Although the number of elderly patients requiring dialysis has increased, data regarding the prognosis of elderly patients undergoing hemodialysis are limited. In the present study, prognosis in Japanese hemodialysis patients aged ≥80 years was evaluated. From January 1988 to July 2013, 1144 consecutive patients with end-stage renal disease required renal replacement therapy at our institution; of these, 141 were aged ≥80 years. These patients’ charts were retrospectively reviewed for relevant clinical variables and survival time. The life expectancies table from the National Vital Statistics database was used, and prognostic factors were assessed by multivariate analysis. In total, 107 deaths (76%) were recorded during the study period. The median survival time and estimated life-shortening period in the patients were 2.6 years and −5.3 years, respectively. Eastern Cooperative Oncology Group Performance Status and hemoglobin level were revealed as prognostic factors in the multivariate analysis. Estimates of prognosis and prognostic factors may provide useful information for physicians as well as elderly patients with end-stage kidney disease

Common-mode noise cancellation circuit for wearable ECG

Wearable electrocardiogram (ECG) is attracting much attention for monitoring heart diseases in healthcare and medical applications. However, an imbalance usually exists between the contact resistances of sensing electrodes, so that a common mode noise caused by external electromagnetic field can be converted into the ECG detection circuit as a differential mode interference voltage. In this study, after explaining the mechanism of how the common mode noise is converted to a differential mode interference voltage, the authors propose a circuit with cadmium sulphide photo-resistors for cancelling the imbalance between the contact resistances and confirm its validity by simulation experiment. As a result, the authors found that the interference voltage generated at the wearable ECG can be effectively reduced to a sufficient small level

Common-mode noise cancellation circuit for wearable ECG

Wearable electrocardiogram (ECG) is attracting much attention for monitoring heart diseases in healthcare and medical applications. However, an imbalance usually exists between the contact resistances of sensing electrodes, so that a common mode noise caused by external electromagnetic field can be converted into the ECG detection circuit as a differential mode interference voltage. In this study, after explaining the mechanism of how the common mode noise is converted to a differential mode interference voltage, the authors propose a circuit with cadmium sulphide photo-resistors for cancelling the imbalance between the contact resistances and confirm its validity by simulation experiment. As a result, the authors found that the interference voltage generated at the wearable ECG can be effectively reduced to a sufficient small level

Ab Initio QM/MM Molecular Dynamics Study on the Excited-State Hydrogen Transfer of 7-Azaindole in Water Solution

Ab initio molecular dynamics (AIMD) simulations for the excited-state hydrogen transfer (ESHT) reaction of 7-azaindole (7AI−(H2O)n; n = 1, 2) clusters in the gas phase and in water are presented. The effective fragment potential (EFP) is employed to model the surrounding water molecules. The AIMD simulations for 7AI−H2O and 7AI−(H2O)2 clusters show an asynchronous hydrogen transfer at t ∼ 50 fs after the photoexcitation. While the ESHT mechanism for 7AI−H2O in water does not change appreciably compared with that in the gas phase, the AIMD simulations on 7AI−(H2O)2 in water solution exhibit two different mechanisms. Since the tautomer form is lower in energy compared to the normal form in the S1 state, 7AI and (H2O)n fragments separate from each other after the ESHT. With the use of the results of the AIMD trajectories, the minimum energy conical intersection point in the tautomer region has also been located.Reprinted (adapted) with permission from Journal of Physical Chemistry A 112 (2008): 9675, doi:10.1021/jp804368p. Copyright 2008 American Chemical Society.</p

Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report

Résumé Contexte Bien que l’extraction oncologique de spermatozoïdes testiculaires (onco-TESE) soit une pratique croissante, le bien-fondé de réaliser une onco-TESE chez des patients qui ont un cancer du testicule reste insuffisamment étayé. Par ailleurs, en cas de cancer bilatéral, qui représente 0,5–1% des cancers du testicule, l’onco-TESE est. plus difficile, et peu de cas ont été rapportés. Cas clinique Nous rapportons le cas d’un homme de 25 ans qui a bénéficié d’une onco-TESE pour tumeur à cellules germinales non séminomateuse sur testicule unique résiduel, survenant 5 ans après une orchidectomie controlatérale. Ont été réalisées simultanément une seconde orchidectomie et une TESE sur tissu testiculaire non tumoral. L’étude anatomopathologique a montré des tumeurs à cellules germinales de plus d’un type histologique (carcinome embryonnaire, tératome immature, tumeur vitelline, séminome, et choriocarcinome; pT1N0M0). Le patient a ensuite convolé en noces et le couple a souhaité avoir un enfant 3 ans plus tard. Alors que l’étude histologique du tissu testiculaire normal donnait un score de Johnsen à 6 (arrêt de maturation), des spermatozoïdes morphologiquement normaux et mobiles ont été retrouvés dans les échantillons de TESE décongelés; ces spermatozoïdes ont été utilisés pour réaliser plusieurs cycles d’injection intra cytoplasmique. Bien qu’aucune conception n’ait eu lieu à ce jour, les tentatives d’ICSI se poursuivent. Conclusions Ce cas montre l’efficacité de l’onco-TESE face à des cas tels qu’un cancer testiculaire bilatéral et non séminomateux