Optical conductivity from pair density waves

We present a theory of optical conductivity in systems with finite-momentum Cooper pairs. In contrast to the BCS pairing where ac conductivity is purely imaginary in the clean limit, there is nonzero ac absorption across the superconducting gap for finite-momentum pairing if we break the Galilean symmetry explicitly in the electronic Hamiltonian. Vertex correction is crucial for maintaining the gauge invariance in the mean-field formalism and dramatically changes the optical conductivity in the direction of the pairing momentum. We carried out a self-consistent calculation and gave an explicit formula for optical conductivity in a simple case. This result applies to the Fulde-Ferrell-Larkin-Ovchinnikov state and candidates with pair density waves proposed for high-T_{c} cuprates. It may help detect pair density waves and determine the pairing gap as well as the direction of the pairing momentum in experiments.National Science Foundation (U.S.) (Grant DMR-1522575

Effective model for Pb9_9Cu(PO4_4)6_6O

The copper substituted Pb-apatite has attracted a great deal of attention recently, due to the claim of the observation of room temperature superconductivity. Based on LDA calculations in the literature, we propose an effective model that describe the low energy physics. It consists of stacks of buckled honeycomb lattices, with Cu and O occupying the A and B sites respectively. In addition to the narrow Cu bands that have been emphasized, we call attention to the relatively small energy separation between the Cu and O orbitals. Thus despite the small hoping energies, the model may be in an interesting regime near the metal insulator transition driven by the charge transfer mechanism. Relationship with cuprates and the organic superconductors are discussed

Fermionic Isometric Tensor Network States in Two Dimensions

We generalize isometric tensor network states to fermionic systems, paving the way for efficient adaptations of 1D tensor network algorithms to 2D fermionic systems. As the first application of this formalism, we developed and benchmarked a time-evolution block-decimation (TEBD) algorithm for real-time and imaginary-time evolution. The imaginary-time evolution produces ground-state energies for gapped systems, systems with a Dirac point, and systems with gapless edge mode to good accuracy. The real-time TEBD captures the chiral edge dynamics on the boundary of a Chern insulator.Comment: 5 + 5 pages, 5 + 4 figure

Pair density wave, charge density wave and vortex in high Tc cuprates

A recent scanning tunneling microscopy (STM) experiment reports the observation of charge density wave (CDW) with period of approximately 8a in the halo region surrounding the vortex core, in striking contrast to the approximately period 4a CDW that are commonly observed in the cuprates. Inspired by this work, we study a model where a bi-directional pair density wave (PDW) with period 8 is at play. This further divides into two classes, (1) where the PDW is a competing state of the d wave superconductor and can exist only near the vortex core where the d wave order is suppressed, and (2) where the PDW is the primary order, the so called mother state that persists with strong phase fluctuations to high temperature and high magnetic field and lies behind the pseudogap phenomenology. We study the charge density wave structures near the vortex core in these models. We emphasize the importance of the phase winding of the d-wave order parameter. The PDW can be pinned by the vortex core due to this winding and become static. Furthermore, the period 8 CDW inherits the properties of this winding, which gives rise to a special feature of the Fourier transform peak, namely, it is split in certain directions. There are also a line of zeros in the inverse Fourier transform of filtered data. We propose that these are key experimental signatures that can distinguish between the PDW-driven scenario from the more mundane option that the period 8 CDW is primary. We discuss the pros and cons of the options considered above. Finally we attempt to place the STM experiment in the broader context of pseudogap physics of underdoped cuprates and relate this observation to the unusual properties of X ray scattering data on CDW carried out to very high magnetic field.Comment: 18 pages, 12 pages; added references and discussed flux density wav

HSF1 overexpression enhances oncolytic effect of replicative adenovirus

<p>Abstract</p> <p>Background</p> <p>E1B55kD deleted oncolytic adenovirus was designed to achieve cancer-specific cytotoxicity, but showed limitations in clinical study. To find a method to increase its efficacy, we investigated the correlation between oncolytic effect of such oncolytic adenovirus Adel55 and intracellular heat shock transcription factor 1 (HSF1) activity.</p> <p>Methods</p> <p>In the present study, human breast cancer cell line Bcap37 was stably transfected with constitutively active HSF1 (cHSF1) or HSF1 specific siRNA (HSF1i) to establish increased or decreased HSF1 expression levels. Cytotoxicity of Adel55 was analyzed in these cell lines <it>in vitro </it>and <it>in vivo</it>. Furthermore, Adel55 incorporated with cHSF1 (Adel55-cHSF1) was used to treat various tumor xenografts.</p> <p>Results</p> <p>Adel55 could achieve more efficient oncolysis in cHSF1 transfected Bcap37 cells, both <it>in vitro </it>and <it>in vivo</it>. However, inhibition of HSF1 expression by HSF1i could rescue Bcap37 cell line from oncolysis by Adel55. A time course study of viral replication established a correlation between higher replication of Adel55 and cytolysis or tumor growth inhibition. Then, we constructed Adel55-cHSF1 for tumor gene therapy and demonstrated that it is more potent than Adel55 itself in oncolysis and replication in both Bcap37 and SW620 xenografts.</p> <p>Conclusions</p> <p>cHSF1 enhances the Adel55 cell-killing potential through increasing the viral replication and is a potential therapeutic implication to augment the potential of E1B55kD deleted oncolytic adenovirus by increasing its burst.</p

Effects of reactive oxygen species and mitochondrial dysfunction on reproductive aging

Mitochondria, the versatile organelles crucial for cellular and organismal viability, play a pivotal role in meeting the energy requirements of cells through the respiratory chain located in the inner mitochondrial membrane, concomitant with the generation of reactive oxygen species (ROS). A wealth of evidence derived from contemporary investigations on reproductive longevity strongly indicates that the aberrant elevation of ROS level constitutes a fundamental factor in hastening the aging process of reproductive systems which are responsible for transmission of DNA to future generations. Constant changes in redox status, with a pro-oxidant shift mainly through the mitochondrial generation of ROS, are linked to the modulation of physiological and pathological pathways in gametes and reproductive tissues. Furthermore, the quantity and quality of mitochondria essential to capacitation and fertilization are increasingly associated with reproductive aging. The article aims to provide current understanding of the contributions of ROS derived from mitochondrial respiration to the process of reproductive aging. Moreover, understanding the impact of mitochondrial dysfunction on both female and male fertility is conducive to finding therapeutic strategies to slow, prevent or reverse the process of gamete aging, and thereby increase reproductive longevity

Modeling the pseudogap metallic state in cuprates: quantum disordered pair density wave

We present a way to quantum-disorder a pair density wave and propose it to be a candidate of the effective low-energy description of the pseudogap metal which may reveal itself in a sufficiently high magnetic field that suppresses the d-wave pairing. The ground state we construct is a small-pocket Fermi liquid with a bosonic Mott insulator in the density-wave-enlarged unit cell. At low energy, the charge density is mainly carried by charge 2e bosons, which develop a small insulating gap. As an intermediate step, we discuss the quantum disordering of a fully gapped superconductor and its excitation spectrum. A simplified 1D model, which we solve numerically, is used to illustrate the introduced concepts. We discuss a number of experimental consequences. The interplay between the electron and the small-gap boson results in a step-function background in the electron spectral function which may be consistent with existing angle-resolved photoemission spectroscopy data. Optical excitation across the boson gap can explain the onset and the magnitude of the mid infrared absorption reported long ago

Exploring strongly interacting gapless states : cuprates, pair density waves, and fluctuating superconductivity

Thesis: Ph. D., Massachusetts Institute of Technology, Department of Physics, May, 2020Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 149-161).We study the physical property of pair density wave (PDW) and fluctuating PDW, and use it to build an effective theory of the strongly interacting pseudogap phase in cuprate high temperature superconductors. In Chapter 2, we study how Fulde-Ferrell state, the simplest form of PDW, responds to incident light. The collective motion of the condensate plays a key role; gauge invariance guides us to the correct result. From Chapter 3 to Chapter 7, we construct a pseudogap metallic state by considering quantum fluctuating PDW. We analyze a recent scanning tunneling microscope (STM) discovery of period-8 density waves in the vortex halo of the d-wave superconductor. We put it in the context of the broader pseudogap phenomenology, and compare the experimental results with various PDW-driven models and a charge density wave (CDW) driven model. We propose experiments to distinguish these different models. We present the Bogoliubov bands of PDW. We discuss fluctuating PDW from the general perspective of fluctuating superconductivity. We discuss how Bogoliubov bands evolve when the superconducting order parameter is fluctuating. We compare theoretical predictions with existing experiments on angle-resolved photoemission spectroscopy (ARPES), infrared conductivity, diamagnetism, and lattice symmetry breaking. The material presented here is based on Ref. [38, 41, 40]. Ref. [39] is not discussed in this thesis but was completed during my time at MIT.by Zhehao Dai.Ph. D.Ph. D. Massachusetts Institute of Technology, Department of Physic