The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Transferring knowledge for organisational customers by knowledge intensive business service marketing firms: An exploratory study

Purpose: The purpose of this paper is to examine the knowledge transfer processes of knowledge intensive business service firms by focusing on the knowledge for customer, which is the knowledge about the service provider's products and services, specifically "before-sale" knowledge, and the transfer of this knowledge in order to develop customers. Design/methodology/approach: The authors conducted an in-depth qualitative study of the knowledge transfer process undertaken by a sample of six global knowledge intensive service firms, to use knowledge transfer as a means of customer development. Findings: The results of this study suggest that customer absorptive capacity influences the role that knowledge for customers has in ultimately determining whether customer development will occur. Where tacit knowledge transfer occurs, it is restricted to loyal, high share customers. With respect to methods of transfer, the findings reveal that knowledge-intensive business service firms transferring explicit knowledge utilise both formal and informal methods. Research limitations/implications: Data collection was cross-sectional and longitudinal research would have the benefit of examining how customer knowledge transfer changes over time during the customer development process (pre-sale, during sale and post-sale customer development). Future research studying other types of knowledge transfer, such as during-sale and after-sale knowledge transfer, are also encouraged. Practical implications: Managers should be open to employing numerous types of media in transferring both explicit and tacit knowledge rather than restricting themselves to the normative "explicit-formal-media lean" versus "tacit-informal-media rich" categorisations in the literature. Originality/value: Understanding the role of customer knowledge transfer in the development of existing organisational customers is particularly important in the context of knowledge intensive business service firms. The extant literature recognises that customer development efforts are critically important in increasing service adoption and firm performance but there exists a dearth of research on customer knowledge transfer in the context of professional service organisations