Development and validation of the Premorbid Childhood Traits Questionnaire (PCT-Q) in eating disorders

PurposeSome features of eating disorders (EDs) are often present in childhood before the onset of the ED. We developed a novel questionnaire to retrospectively capture such childhood traits.MethodsFocus groups were conducted at the University of California-San Diego, USA, and at the University of Turin, Italy. Three focus groups were conducted at each site, interviewing patients and parents to identify those traits that most commonly characterize childhood of patients with EDs. A preliminary version of the Premorbid Childhood Traits Questionnaire (PCT-Q) derived from these focus groups was then administered to 94 consecutive inpatients with an ED and to 286 healthy controls (HCs) at the Turin site. Also, 208 participants' parents were enrolled as well; in fact, the PCT-Q was developed with both a proband and an informant version.ResultsA 37-item final version of the PCT-Q was generated. Reliability analyses suggested acceptability for harm avoidance (HA), social phobia, alexithymia, interoceptive awareness (IA), and food obsessions. Inter-rater reliability ranged from fair to moderate. ED sufferers scored significantly higher than HCs on HA, social phobia, alexithymia, IA, and food obsessions.ConclusionsThese findings support the possibility that premorbid traits contribute to a risk to develop an ED in some individuals.Level of evidenceIII: case-control analytic study

Propagation of Policies in Rich Data Flows

Governing the life cycle of data on the web is a challenging issue for organisations and users. Data is distributed under certain policies that determine what actions are allowed and in which circumstances. Assessing what policies propagate to the output of a process is one crucial problem. Having a description of policies and data flow steps implies a huge number of propagation rules to be specified and computed (number of policies times number of actions). In this paper we provide a method to obtain an abstraction that allows to reduce the number of rules significantly. We use the Datanode ontology, a hierarchical organisation of the possible relations between data objects, to compact the knowledge base to a set of more abstract rules. After giving a definition of Policy Propagation Rule, we show (1) a methodology to abstract policy propagation rules based on an ontology, (2) how effective this methodology is when using the Datanode ontology, (3) how this ontology can evolve in order to better represent the behaviour of policy propagation rules

Evaluation in vitro et in vivo des proprietes anthelminthiques de feuilles de Spondias mombin sur Haemonchus contortus des ovins djallonke

Depuis longtemps, la lutte contre les maladies animales s’est faite avec l’utilisation des molécules chimiques de synthèse. Cette lutte chimique est à l’origine du développement de résistance de certains agents pathogènes. Face à cette contrainte, de nouvelles méthodes de lutte sont envisagées. La présente étude se propose d’évaluer in vitro et in vivo, les propriétés anthelminthiques de Spondias mombin sur Haemonchus contortus chez les ovins Djallonké. Des tests biologiques des extraits éthanoliques et méthanoliques de la plante ont été effectués sur les larves L3 et sur les vers adultes de H contortus. Pour les essais in vivo, trois lots de brebis parasitées sont constitués : Témoin sans traitement; Lot 1 et Lot 2 recevant respectivement 1,45g et 2,9g /kg/animal de poudre de feuilles de S. mombin pendant trois jours. Les tests in vitro ont montré des valeurs significatives (p < 0,01) de la capacité des extraits de S. mombin à inhiber la migration des larves L3 (45 à 80 %) et à réduire la motilité des vers adultes après 30 heures d’exposition (77 à 100 %), comparativement au témoin de référence négatif (PBS). L’activité antiparasitaire des feuilles de S. mombin obtenue in vitro est confirmée in vivo sur les brebis. Les résultats des travaux révèlent que les traitements avec la poudre de S. mombin a permis une réduction de plus de 50 % du niveau d’excrétion des œufs chez les brebis traitées. Mots clés : Parasites, Haemonchus contortus, ovins Djallonké, Spondias mombin. Anthelmintic activity of Spondias mombin ‘sleaves against Haemonchus contortusFor a long time, the fight against animal diseases has been done with the use of synthetic chemical molecules. This chemical fight is at the origin of the development of resistance of certain pathogens. Faced with this constraint, new control methods are being considered. This study proposes to evaluate in vitro and in vivo, the anthelmintic properties of Spondias mombin on Haemonchus contortus of Djallonke sheep. Biological tests of the ethanolic and methanolic extracts of the plant were carried out on the L3 larvae and on the adult worms of H contortus. For in vivo tests, three lots of parasitized ewes consist of: Control without treatment; Lot 1 and Lot 2 receiving respectively 1.45g and 2.9 g / kg / animal leaf powder of S. mombin for three days. In vitro tests showed significant (p < 0.01) values of the ability of S. mombin extracts to inhibit the migration of L3 larvae (45 - 80 %) and to reduce the motility of adult worms after 30 hours. exposure (77 to 100 %), compared to the negative reference control (PBS). It should be noted that, in general, the anthelmintic activity of S. mombin extracts is not influenced by the type of solvent used. The anti-parasitic activity of S. mombin leaves obtained in vitro is confirmed in vivo in ewes. The results of the work show that treatments with S. mombin powder resulted in a reduction of more than 50 % in the level of egg excretion in treated ewes. Key words: Parasites, Haemonchus contortus, Djallonke sheep, Spondias mombin

Producción académica y editorial de las universidades públicas peruanas. Caso: Universidad Nacional del Centro del Perú

The National University of Central Peru was founded in 1959. Since then, its academic and editorial production has been maintained until today. Our goal is to chronologically analyze the production of books and journals in this university. It is an exploratory analysis that covers the period 1963-2019. The results show an evolutionary and progressive bibliographic and hemerographic increase. The editorial administration of the teaching and research center, in the current secrecy, gives clear evidence to assume criteria such as open access and internationalization. However, it is concluded that the virtualization of production is urgently needed, which is part of institutional and regional memory.La Universidad Nacional del Centro del Perú fue fundada en 1959. Desde entonces su producción académica y editorial se ha sostenido hasta la actualidad. La presente investigación planteó como objetivo analizar cronológicamente la generación de libros y revistas de esta casa de estudios universitarios. Se trata de un análisis exploratorio que abarca el periodo 1963-2019. Los resultados evidenciaron un evolutivo y progresivo incremento bibliográfico y hemerográfico. La gestión editorial de este centro de enseñanza e investigación en el presente siglo da muestras claras de asumir criterios como el acceso abierto y la internacionalización. Se concluye que urge virtualizar el material producido, el mismo que constituye un componente de la memoria institucional y regional

Konstruksi Makna Lansia pada Dunia Kerja dalam Film The Intern

Penelitian ini bertujuan untuk mengetahui Konstruksi makna lansia pada dunia kerja dalam film The Intern. Penelitian ini menggunakan metode Analisis Semiotika John Fiske dengan memakai kode-kode sosial John Fiske yaitu Level Realitas, Level Representasi dan Level Ideologi. Hasil penelitian yang diperoleh dari penelitian ini berdasarkan kode televisi yaitu, pada level realitas konstruksi makna lansia yang dibentuk adalah seorang lansia memiliki kecendrungan untuk tampil formal dalam berbagai kesempatan. Seorang lansia juga masih memiliki kemampuan untuk mengurus dirinya sendiri dan bekerja untuk memberikan sisa-sisa kemampuannya. Banyaknya pengalaman yang dimiliki membantu dalam memecahkan berbagai persoalan yang sedang terjadi. Pada level representasi konstruksi makana lansia yangt dibentuk adalah seorang lansia masih memiliki hasrat untuk memberikan kemampuan terbaiknya dan beradaptasi dengan perkembangan zaman (teknologi). Lansia membutuhkan penerimaan dalam lingkungan di mana dirinya berada sehingga memudahkan proses beradaptasi.Pada level ideologi konstruksi makna lansia yang dibentuk adalah seorang lansia memiliki sikap rendah hati dan bersedia membantu dan bekerja sebaik mungkin dalam lingkungannya. Lansia memiliki prinsip kerja yang dijunjung tinggi oleh dirinya. Selain itu seorang lansia bersedia mendengarkan arahan agar memudahkan dirinya untuk beradaptasi terhadap lingkungan barunya

Sustained platelet-sparing effect of weekly low dose paclitaxel allows effective, tolerable delivery of extended dose dense weekly carboplatin in platinum resistant/refractory epithelial ovarian cancer

Background: Platinum agents have shown demonstrable activity in the treatment of patients with platinum resistant, recurrent ovarian cancer when delivered in a "dose-dense" fashion. However, the development of thrombocytopenia limits the weekly administration of carboplatin to no greater than AUC 2. Paclitaxel has a well-described platelet sparing effect however its use to explicitly provide thromboprotection in the context of dose dense carboplatin has not been explored. Methods: We treated seven patients with platinum resistant ovarian cancer who had previously received paclitaxel or who had developed significant peripheral neuropathy precluding the use of further full dose weekly paclitaxel. Results: We were able to deliver carboplatin AUC 3 and paclitaxel 20 mg/m(2) with no thrombocytopenia or worsening of neuropathic side-effects, and with good activity. Conclusions: We conclude that this regimen may be feasible and active, and could be formally developed as a "platinum-focussed dose-dense scaffold" into which targeted therapies that reverse platinum resistance can be incorporated, and merits further evaluation

The 2019 and 2021 International Workshops on Alport Syndrome

In 1927 Arthur Cecil Alport, a South African physician, described a British family with an inherited form of kidney disease that affected males more severely than females and was sometimes associated with hearing loss. In 1961, the eponymous name Alport syndrome was adopted. In the late twentieth century three genes responsible for the disease were discovered: COL4A3, COL4A4, and COL4A5 encoding for the α3, α4, α5 polypeptide chains of type IV collagen, respectively. These chains assemble to form heterotrimers of type IV collagen in the glomerular basement membrane. Scientists, clinicians, patient representatives and their families, and pharma companies attended the 2019 International Workshop on Alport Syndrome, held in Siena, Italy, from October 22 to 26, and the 2021 online Workshop from November 30 to December 4. The main topics included: disease re-naming, acknowledging the need to identify an appropriate term able to reflect considerable clinical variability; a strategy for increasing the molecular diagnostic rate; genotype-phenotype correlation from monogenic to digenic forms; new therapeutics and new therapeutic approaches; and gene therapy using gene editing. The exceptional collaborative climate that was established in the magical medieval setting of Siena continued in the online workshop of 2021. Conditions were established for collaborations between leading experts in the sector, including patients and drug companies, with the aim of identifying a cure for Alport syndrome