Lack of Association between Apolipoprotein E Polymorphism with Age at Onset of Subcortical Vascular Dementia

Background and Purpose: The relationship between apolipoprotein E (ApoE) and onset of vascular dementia remains controversial. The aim of this study was to evaluate the relationship between ApoE polymorphism and the onset of subcortical vascular dementia (SVaD) compared to Alzheimer’s disease (AD) and normal controls. Methods: The study was comprised of 61 patients with SVaD (42 Binswanger type, 19 lacunar type) and 112 patients with AD (16 early-onset AD, 96 late-onset AD) as well as 284 age-, gender- and education-matched normal controls. The diagnosis of SVaD was based on modified NINDS-AIREN criteria, and the diagnosis of AD was based on NINCDS-ADRDA criteria. ApoE polymorphism was genotyped in all participants. Results: None of the three ApoE alleles was more prevalent in SVaD patients compared to normal controls, which was the case when both Binswanger and lacunar types were analyzed separately. ApoE Ε4 did not accelerate the onset of SVaD (OR 1.66, 95% CI: 0.8–3.4), in contrast to a significant relation with late-onset AD (OR 3.78, 95% CI: 2.2–6.5). Conclusion: Our results suggest that ApoE polymorphism is not associated with the onset of SVaD and that the two subtypes of SVaD may share similar pathophysiologies

Ejection of Double knots from the radio core of PKS 1510--089 during the strong gamma-ray flares in 2015

PKS 1510--089 is a bright and active $\gamma$-ray source that showed strong and complex $\gamma$-ray flares in mid-2015 during which the Major Atmospheric Gamma Imaging Cherenkov telescopes detected variable very high energy (VHE; photon energies $>$100 GeV) emission. We present long-term multi-frequency radio, optical, and $\gamma$-ray light curves of PKS 1510--089 from 2013 to 2018, and results of an analysis of the jet kinematics and linear polarization using 43 GHz Very Long Baseline Array data observed between late 2015 and mid-2017. We find that a strong radio flare trails the $\gamma$-ray flares in 2015, showing an optically thick spectrum at the beginning and becoming optically thin over time. Two laterally separated knots of emission are observed to emerge from the radio core nearly simultaneously during the $\gamma$-ray flares. We detect an edge-brightened linear polarization near the core in the active jet state in 2016, similar to the quiescent jet state in 2008--2013. These observations indicate that the $\gamma$-ray flares may originate from compression of the knots by a standing shock in the core and the jet might consist of multiple complex layers showing time-dependent behavior, rather than of a simple structure of a fast jet spine and a slow jet sheath.Comment: 11 pages, 7 figures, To appear in Ap