1 research outputs found
Exogenous application of glucose induces aging in rat cerebral oligodendrocytes as revealed by alteration in telomere length
To investigate aspects of aging on rat oligodendrocytes, cells of an oligodendrocyte cell line, so-called OLN-93, were cultured either in
the presence or absence of glucose. Our data demonstrated that glucose-induced aging in vitro caused an elongation and thickening of cell
processes and significantly increased the expression of netrin reflecting a more mature state of oligodendrocyte development. A possible
age-inducing effect of glucose is also supported by the decrease of ras protein expression and shortening of telomeres in glucose-treated
oligodendrocytes. The present study clearly shows that OLN-93 cells are an exciting and suitable model system for the investigation of
age-inducing molecules and the analysis of signaling pathways involved in cerebral aging and degenerations.
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