Gene-based associations of <i>SGK1</i>, <i>SGK2</i> and <i>SGK3</i> with blood pressure responses to dietary sodium intervention.

<p>BP, blood pressure; SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure;</p><p>*Significant <i>P</i> values after Bonferroni correction.</p

Characteristics of <i>SGK1, SGK2</i> and <i>SGK3</i> genes.

<p>Chr, chromosome; SNP, single-nucleotide polymorphism.</p

Blood pressure responses to high sodium intervention among participants with different genotypes of rs2758151, respectively.

<p>*significant after Bonferroni correction.</p

Characteristics of 1,906 GenSalt dietary intervention participants.

<p>BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure;</p><p>*<i>P</i><0.0001 when comparing blood pressure change with 0.</p

Mean adjusted eGFR as a result of the genotypic interaction between CYP11B1_rs4541 and ADRB2_rs1042718.

<p>The data points represent the eGFR for the nine possible combinations of the three <i>ADRB2</i> genotypes versus each of the three possible <i>CYP11B1</i> genotypes. The number of individuals at each point is provided.</p

SNPs that showed significant associations with eGFR in GenSalt participants.

<p>HWpval: Hardy-Weinberg p value, MAF: minor allele frequency, Maj/Min: Major/Minor allele.</p><p>*p values adjusted for age, age², age³, gender, BMI, high density lipoprotein cholesterol (HDL-C), hypertension, field center, and family structure.</p

Basic characteristics of the study subjects.

<p>HDL: High Density Lipoprotein, eGFR: estimated Glomerular Filtration Rate.</p><p>Values are mean ± standard deviation for Age, Body Mass Index, HDL, serum creatinine, and eGFR.</p

Novel SNVs/Genes associated with BP traits from correlated meta-analysis in European ancestry in Stage 1.

<p>Novel SNVs/Genes associated with BP traits from correlated meta-analysis in European ancestry in Stage 1.</p

Identification of four independent LD blocks in the 8p23.1 region <i>(~3</i>.<i>3 MBs</i>).

<p>Identification of four independent LD blocks in the 8p23.1 region <i>(~3</i>.<i>3 MBs</i>).</p

Potential novel SNVs/Genes associated with BP traits in African ancestry.

<p>Potential novel SNVs/Genes associated with BP traits in African ancestry.</p