Kinetic behavior of the general modifier mechanism of Botts and Morales with non-equilibrium binding

In this paper, we perform a complete analysis of the kinetic behavior of the general modifier mechanism of Botts and Morales in both equilibrium steady states and non-equilibrium steady states (NESS). Enlightened by the non-equilibrium theory of Markov chains, we introduce the net flux into discussion and acquire an expression of product rate in NESS, which has clear biophysical significance. Up till now, it is a general belief that being an activator or an inhibitor is an intrinsic property of the modifier. However, we reveal that this traditional point of view is based on the equilibrium assumption. A modifier may no longer be an overall activator or inhibitor when the reaction system is not in equilibrium. Based on the regulation of enzyme activity by the modifier concentration, we classify the kinetic behavior of the modifier into three categories, which are named hyperbolic behavior, bell-shaped behavior, and switching behavior, respectively. We show that the switching phenomenon, in which a modifier may convert between an activator and an inhibitor when the modifier concentration varies, occurs only in NESS. Effects of drugs on the Pgp ATPase activity, where drugs may convert from activators to inhibitors with the increase of the drug concentration, are taken as a typical example to demonstrate the occurrence of the switching phenomenon.Comment: 19 pages, 10 figure

Orbital density wave induced by electron-lattice coupling in orthorhombic iron pnictides

In this paper we explore the magnetic and orbital properties closely related to a tetragonal-orthorhombic structural phase transition in iron pnictides based on both two- and five-orbital Hubbard models. The electron-lattice coupling, which interplays with electronic interaction, is self-consistently treated. Our results reveal that the orbital polarization stabilizes the spin density wave (SDW) order in both tetragonal and orthorhombic phases. However, the ferro-orbital density wave (F-ODW) only occurs in the orthorhombic phase rather than in the tetragonal one. Magnetic moments of Fe are small in the intermediate Coulomb interaction region for the striped antiferromangnetic phase in the realistic five orbital model. The anisotropic Fermi surface in the SDW/ODW orthorhombic phase is well in agreement with the recent angle-resolved photoemission spectroscopy experiments. These results suggest a scenario that the magnetic phase transition is driven by the ODW order mainly arising from the electron-lattice coupling.Comment: 21 pages, 10 figure

Giant negative magnetoresistance induced by the chiral anomaly in individual Cd3As2 nanowires

Cd3As2 is a newly booming Dirac semimetal with linear dispersion along all three momentum directions and can be viewed as 3D analog of graphene. As breaking of either time reversal symmetry or spatial inversion symmetry, the Dirac semimetal is believed to transform into Weyl semimetal with exotic chiral anomaly effect, while the experimental evidence of the chiral anomaly is still missing in Cd3As2. Here we report the magneto-transport properties of individual Cd3As2 nanowires. Large negative magnetoresistance (MR) with magnitude of -63% at 60 K and -11% at 300 K are observed when the magnetic field is parallel with the electric field direction, giving the evidence of the chiral magnetic effect in Cd3As2 nanowires. In addition, the critical magnetic field BC, where there is an extremum of the negative MR, increases with increasing temperature. As the first observation of chiral anomaly induced negative MR in Cd3As2 nanowires, it may offer valuable insights for low dimensional physics in Dirac semimetals.Comment: 4 figure

Solutions to integrable space-time shifted nonlocal equations

In this paper we present a reduction technique based on bilinearization and double Wronskians (or double Casoratians) to obtain explicit multi-soliton solutions for the integrable space-time shifted nonlocal equations introduced very recently by Ablowitz and Musslimani in [Phys. Lett. A, 2021]. Examples include the space-time shifted nonlocal nonlinear Schr\"odinger and modified Korteweg-de Vries hierarchies and the semi-discrete nonlinear Schr\"odinger equation. It is shown that these nonlocal integrable equations with or without space-time shift(s) reduction share same distributions of eigenvalues but the space-time shift(s) brings new constraints to phase terms in solutions.Comment: 16 page