130 research outputs found
A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth
Background: The stromal microenvironment and particularly the macrophage component of primary tumors influence their malignant potential. However, at the metastatic site the role of these cells and their mechanism of actions for establishment and growth of metastases remain largely unknown. Methodology/Principal Findings: Using animal models of breast cancer metastasis, we show that a population of host macrophages displaying a distinct phenotype is recruited to extravasating pulmonary metastatic cells regardless of species of origin. Ablation of this macrophage population through three independent means (genetic and chemical) showed that these macrophages are required for efficient metastatic seeding and growth. Importantly, even after metastatic growth is established, ablation of this macrophage population inhibited subsequent growth. Furthermore, imaging of intact lungs revealed that macrophages are required for efficient tumor cell extravasation. Conclusion/Significance: These data indicate a direct enhancement of metastatic growth by macrophages through their effects on tumor cell extravasation, survival and subsequent growth and identifies these cells as a new therapeutic target fo
Experimental studies of e + e -β some charmless processes containing K S0 at βs = 3.773 and 3.65 GeV
We measure the observed cross sections for the charmless processes e + e -βK S0 K - K - K + Ο ++ c.c., K S0 K - Ο + Ξ·+c.c., K S0 K - Ο + Ο + Ο - Ξ·+c.c., K S0 K - K - K + Ο + Ξ·+c.c., K S0 K - K - K + Ο + Ο 0+c.c., K S0 K - Ο ++c.c. and K S0 K - Ο + Ο 0+c.c. We also extract upper limits on the branching fractions for Ο(3770) decays into these final states at 90% C.L. Analyzed data samples correspond to 17.3 pb-1 and 6.5 pb-1 integrated luminosities registered, respectively, at βs = 3.773 and 3.65 GeV, with the BES-II detector at the BEPC collider. Β© 2009 Springer-Verlag / SocietΓ Italiana di Fisica.published_or_final_versionSpringer Open Choice, 21 Feb 201
Search for Ο(3770)β charmless final states involving Ξ· or Ο0 mesons
We search for Ο(3770) β Ο+Ο-Ξ·, K+K-Ξ·, ppΜΞ·, Ο0Ο+Ο-Ξ·, K+K-Ο+Ο-Ξ·, ppΜΟ+Ο-Ξ·, ppΜK+K-Ξ· and ppΜK+K- Ο0 using data samples of 17.3 and 6.5 pb-1 integrated luminosities recorded at the center-of-mass energies of 3.773 and 3.65 GeV, respectively, by the BES-II detector operating at the BEPC collider. We obtain cross section measurements at both energies and upper limits on Ο(3770) decay branching fractions to the final states studied. Β© Β© Springer-Verlag / SocietΓ Italiana di Fisica 2010.published_or_final_versionSpringer Open Choice, 21 Feb 201
CCL21-CCR7 promotes the lymph node metastasis of esophageal squamous cell carcinoma by up-regulating MUC1
Ba(Zn1β2xMnxCux)2As2: A Bulk Form Diluted Ferromagnetic Semiconductor with Mn and Cu Codoping at Zn Sites
Detection and material identification of loose particles inside the aerospace power supply via stochastic resonance and LVQ network
Development of a real-time loop-mediated isothermal amplification method for the detection of severe fever with thrombocytopenia syndrome virus
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