8 research outputs found
Novel immunohistochemistry-based signatures to predict metastatic site of triple-negative breast cancers
- Author
- A Dankof
- A Jemal
- AA Luck
- AD Bull
- AJ Minn
- Andrew R Green
- AT Alshareeda
- B Smolarz
- B Weigelt
- B Weigelt
- BE Hillner
- BH Spain
- C Liedtke
- C Massard
- CK Anders
- D Bernard-Gallon
- D Malin
- D Palmieri
- DA Jerjees
- DM Abd El-Rehim
- DM Abd El-Rehim
- DW Cleere
- DX Nguyen
- E Buache
- E Dahl
- EA Rakha
- EA Rakha
- EA Rakha
- EA Rakha
- Emad A Rakha
- Emiel AM Janssen
- F Cardoso
- G Hu
- G Lorusso
- GD Roodman
- GP Gupta
- GP Gupta
- GP Gupta
- GR Mundy
- H Kennecke
- HO Habashy
- Ian O Ellis
- IJ Fidler
- JF Deeken
- JK Perry
- JS Barnholtz-Sloan
- K Pogoda
- KD Voduc
- KJ Klos
- KJ Luzzi
- L Kai
- M Smid
- M Smid
- MA Aleskandarany
- MH Galea
- Mohammed A Aleskandarany
- MR Smith
- MS Sheikh
- OL Bohn
- P Winczura
- Padmashree CG Rida
- PD Bos
- PS Steeg
- R Abduljabbar
- R Coleman
- R Kumar
- R Largillier
- R Mihai
- RB Hazan
- Ritu Aneja
- RJ Weil
- S Hiratsuka
- S Park
- SB Pakala
- SE Elsheikh
- Sergey Klimov
- SH Park
- SJ Prest
- SM Arnold
- SM Mahmoud
- T Landemaine
- T Powles
- Timothy Caulfield
- U Cavallaro
- WS Chen
- YTNM Lee
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 05/09/2017
- Field of study
Background: Although distant metastasis (DM) in breast cancer (BC) is the most lethal form of recurrence and the most commonunderlying cause of cancer related deaths, the outcome following the development of DM is related to the site of metastasis.Triple negative BC (TNBC) is an aggressive form of BC characterised by early recurrences and high mortality. Athough multiplevariables can be used to predict the risk of metastasis, few markers can predict the specific site of metastasis. This study aimed atidentifying a biomarker signature to predict particular sites of DM in TNBC.Methods: A clinically annotated series of 322 TNBC were immunohistochemically stained with 133 biomarkers relevant to BC, todevelop multibiomarker models for predicting metastasis to the bone, liver, lung and brain. Patients who experienced metastasisto each site were compared with those who did not, by gradually filtering the biomarker set via a two-tailed t-test and Coxunivariate analyses. Biomarker combinations were finally ranked based on statistical significance, and evaluated in multivariableanalyses.Results: Our final models were able to stratify TNBC patients into high risk groups that showed over 5, 6, 7 and 8 times higher riskof developing metastasis to the bone, liver, lung and brain, respectively, than low-risk subgroups. These models for predictingsite-specific metastasis retained significance following adjustment for tumour size, patient age and chemotherapy status.Conclusions: Our novel IHC-based biomarkers signatures, when assessed in primary TNBC tumours, enable prediction of specificsites of metastasis, and potentially unravel biomarkers previously unknown in site tropism
Notes on the breeding behaviour and nesting preferences of Blackish nightjar ( Nyctipolus nigrescens
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
SOLTI NeoPARP: a phase II randomized study of two schedules of iniparib plus paclitaxel versus paclitaxel alone as neoadjuvant therapy in patients with triple-negative breast cancer
- Author
- AG Patel
- AG Patel
- Ana Casas
- Antonio Llombart-Cussac
- Begoña Bermejo
- Claudia Aura
- CM Kelly
- Cristian Villanueva
- DW Cleere
- Eric Charpentier
- FJ Esteva
- Henri Roché
- Hervé Bonnefoi
- HS Rugo
- Ignacio Garcia-Ribas
- J O’Shaughnessy
- J O’Shaughnessy
- JoaquÃn Gavilá
- Jose Baselga
- Judith Balmaña
- Kepa Amillano
- Luis Manso
- MC Green
- Nadia Harbeck
- Nina Radosevic-Robin
- P Cortazar
- Pedro Sánchez-Rovira
- Santiago Gonzalez-Santiago
- SerafÃn Morales
- Serena Di Cosimo
- Suzette Delaloge
- V Ossovskaya
- V Ossovskaya
- X Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Kaiso depletion attenuates transforming growth factor-β signaling and metastatic activity of triple-negative breast cancer cells
- Author
- A Prat
- A Prokhortchouk
- A Puisieux
- A Rojas
- B Li
- BH Lloyd
- C Chen
- CC Pierre
- CC Pierre
- CH Heldin
- CM Perou
- D Hanahan
- D Padua
- D Sarrio
- DW Cleere
- E Iorns
- EA Musgrove
- EC Lopes
- EW Thompson
- G Portella
- J Ferlay
- J Jones
- J Jones
- J Pannu
- J Xu
- JF Vermeulen
- JJ Yin
- JM Daniel
- JM Daniel
- JM Drake
- JV Joseph
- LM Wakefield
- N Yamashita
- NS Donaldson
- NS Donaldson
- P Karihtala
- PS Steeg
- R Chaudhary
- R Kalluri
- R Serra
- RJ Akhurst
- RM Neve
- S Ammanamanchi
- SD Dai
- TT Onder
- U Valcourt
- V Ganapathy
- WD Foulkes
- Y Adachi
- YE Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Suppression of triple-negative breast cancer metastasis by pan-DAC inhibitor panobinostat via inhibition of ZEB family of EMT master regulators
- Author
- A Aghdassi
- A Eger
- B Weigelt
- BC Fuchs
- BP Schneider
- Brian G. Rowan
- Bridgette M. Collins-Burow
- C Loriot
- C Vandewalle
- C Zhou
- C Zhou
- CG Marsden
- Chandra R. Tate
- CK Anders
- CR Tate
- D Kong
- D Kong
- DC Drummond
- Diari Gilliam
- Douglas B. Chrisey
- DW Cleere
- E Vincan
- EW Bradley
- F Wang
- F. Nell Pounder
- G Berx
- GM Jiang
- H Huang
- H Huang
- H Takada
- H. Chris Segar
- Hope E. Burks
- J Comijn
- JP Thiery
- K Hibi
- K Morioka
- KT Lin
- L O’Driscoll
- LV Rhodes
- Lyndsay V. Rhodes
- M Guarino
- M Kakihana
- M Laurentiis De
- M Nozato
- Matthew E. Burow
- MI Kokkinos
- MU Naik
- Muralidharan Anbalagan
- MY Feng
- N Fortunati
- O Schmalhofer
- OJ Scully
- P Atadja
- P Cowin
- R Dent
- RD Chacon
- RM Neve
- S Abuharbeid
- Steven Elliott
- T Liu
- Theresa B. Phamduy
- Van Hoang
- Y Wang
- Z Jiang
- Z Shan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The citation impact of articles from which authors gained monetary rewards based on journal metrics
- Author
- A Abritis
- A Geuna
- A Miroiu
- A Perianes-Rodriguez
- A Schubert
- AI Pudovkin
- B Good
- B Hammarfelt
- C Bergstrom
- C Bergstrom
- C Franzoni
- C Osuna
- D Aboal
- D Cutas
- D Hicks
- D Hicks
- D Pajić
- D Teodorescu
- DA Pendlebury
- DH Kim
- DW Hedding
- E Jiménez-Contreras
- E Kulczycki
- European Commission
- F Shu
- G Sivertsen
- G-A Vîiu
- G-A VÈ‹iu
- GA Lozano
- H Wickham
- H-J Bak
- HF Moed
- HF Moed
- J Kozlowski
- J Ruiz-Castillo
- J Ruiz-Castillo
- J Vanecek
- JPA Ioannidis
- JS Heywood
- JW Schneider
- K Aagaard
- L Bornmann
- L Bornmann
- L Bornmann
- L Cleere
- L Leydesdorff
- L Leydesdorff
- L Ma
- L Vlăsceanu
- L Waltman
- M Franceschet
- M Kozak
- M Osterloh
- M Thelwall
- M Trow
- MH MacRoberts
- MW Neff
- P Albarrán
- P Korytkowski
- P Pisár
- P Pisár
- P Vinkler
- PO Seglen
- PO Seglen
- Q Wang
- R Miranda
- R Müller
- S Curry
- S Milojević
- SB Demir
- T Braun
- U Sandström
- V Larivière
- V Larivière
- V Sandoval-Romero
- W Liu
- W Quan
- Y Gingras
- Y Tonta
- Y Tonta
- Ü Must
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Novel immunohistochemistry-based signatures to predict metastatic site of triple-negative breast cancers
- Author
- A Dankof
- A Jemal
- AA Luck
- AD Bull
- AJ Minn
- Andrew R Green
- AT Alshareeda
- B Smolarz
- B Weigelt
- B Weigelt
- BE Hillner
- BH Spain
- C Liedtke
- C Massard
- CK Anders
- D Bernard-Gallon
- D Malin
- D Palmieri
- DA Jerjees
- DM Abd El-Rehim
- DM Abd El-Rehim
- DW Cleere
- DX Nguyen
- E Buache
- E Dahl
- EA Rakha
- EA Rakha
- EA Rakha
- EA Rakha
- Emad A Rakha
- Emiel AM Janssen
- F Cardoso
- G Hu
- G Lorusso
- GD Roodman
- GP Gupta
- GP Gupta
- GP Gupta
- GR Mundy
- H Kennecke
- HO Habashy
- Ian O Ellis
- IJ Fidler
- JF Deeken
- JK Perry
- JS Barnholtz-Sloan
- K Pogoda
- KD Voduc
- KJ Klos
- KJ Luzzi
- L Kai
- M Smid
- M Smid
- MA Aleskandarany
- MH Galea
- Mohammed A Aleskandarany
- MR Smith
- MS Sheikh
- OL Bohn
- P Winczura
- Padmashree CG Rida
- PD Bos
- PS Steeg
- R Abduljabbar
- R Coleman
- R Kumar
- R Largillier
- R Mihai
- RB Hazan
- Ritu Aneja
- RJ Weil
- S Hiratsuka
- S Park
- SB Pakala
- SE Elsheikh
- Sergey Klimov
- SH Park
- SJ Prest
- SM Arnold
- SM Mahmoud
- T Landemaine
- T Powles
- Timothy Caulfield
- U Cavallaro
- WS Chen
- YTNM Lee
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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- AG Szabo
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- S Aktipis
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- S. L. Gaff in and S. Watanabe J
- S. L. Gaff in and S. Watanabe J
- S. S. L
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- VV Mesyanzhinov
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- Y Tominatsu
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- Y Watanabe
- Y Yamasai
- Y Yasukochi
- Y Yasukochi
- Y Yoshida
- Y Yoshida
- Y Yoshida
- Y. Miyake T. Abe, and T. Yamano, in International Symposium on Oxidases and Related Redox Systems
- YA Sharonov
- YA Sharonov
- YA Sharonov
- YE Erokhin
- YJ Kang
- YK Turakulov
- YK Turakulov
- YK Yip
- YP Lin
- YP Meyer
- YP Meyer
- YP Meyer
- YP Myer
- YS Choong
- YS Choong
- YV Peive
- YV Peive
- YV Pieve
- YV Shtamm
- YY Vasilev
- YYH Chao
- Z Bradic
- Z Gasyna
- Z Vogel
- Z Zak
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1984
- Field of study