Evolution des incisives chez les bovins

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Fecundity and spawning of the Atlantic horseshoe crab, Limulus polyphemus, in Pleasant Bay, Cape Cod, Massachusetts, USA

Author Posting. © The Authors, 2005. This is the author's version of the work. It is posted here by permission of Blackwell for personal use, not for redistribution. The definitive version was published in Marine Ecology 27 (2006): 54-65, doi:10.1111/j.1439-0485.2005.00053.x.This study provided the first comprehensive analysis of Atlantic horseshoe crab (Limulus polyphemus) fecundity. Limulus appear to be determinate spawners, maturing all their eggs for the breeding season before spawning begins. On average, larger females held a larger number of eggs (63,500) than smaller females (14,500). By the end of the breeding season there was an average of 11,600 mature eggs female-1 left undeposited, regardless of female size. Larger females laid a higher percentage of the eggs they contained. Thus they not only contain more eggs, but are more effective at laying them as well. Size of spawning females ranged from about 185-300 mm prosomal width, with by far the highest concentration in the mid-size ranges. Although on an individual basis large females carry and lay the greatest number of eggs, mid-size crabs as a group contributed more to the horseshoe crab population in Pleasant Bay because they were more plentiful (net fecundity was highest for mid-size crabs). These results have implications for the management of this important species, which is harvested for bait, scientific, and biomedical uses. Incorporation of these results into models and other management tools can help predict growth rates, effects of size-selective harvest, reproductive value, and stable stage distribution of populations.This project was partially funded by MIT Sea Grant 8247-5

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

Composition et valeur nutritive de la viande bovine

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Importance relative des caracteres sensoriels (tendrete, saveur, jutosite) sur l'acceptabilite de la viande de boeuf par les consommateurs

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Variation de la morphologie du jambon et relation avec le rapport muscle/os

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Relationships between characteristics of muscle development in the pig carcass

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Note sur les variations anatomiques des caracteristiques qualitatives des viandes de porc

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