10 research outputs found
Diagnosis of late-onset Pompe disease and other muscle disorders by next-generation sequencing
Full text linkRockfall Hazard Rating System along SH-72: a case study of Poladpur–Mahabaleshwar road (Western India), Maharashtra, India
No full textGeomechanical interpretation of the Downie Slide considering field data and three-dimensional numerical modelling
No full textLeveraging historical aerial photographs and digital photogrammetry techniques for landslide investigation—a practical perspective
No full textApplication of spatial prediction techniques to defining three-dimensional landslide shear surface geometry
No full textAn analysis of failure mechanism constraints on pre-failure rock block deformation using TLS and roto-translation methods
No full textRock Mass Characterization and Support Assessment along Power Tunnel of Hydropower in Kohistan Area, KPK, Pakistan
No full textAssessment of rock slope stability and structurally controlled failures along Samma escarpment road, Asir Region (Saudi Arabia)
No full textIslet G protein-coupled receptors as potential targets for treatment of type 2 diabetes.
No full textIslet dysfunction - characterized by a combination of defective insulin secretion, inappropriately high glucagon secretion and reduced beta-cell mass - has a central role in the pathophysiology of type 2 diabetes. Several G protein-coupled receptors (GPCRs) expressed in islet beta-cells are known to be involved in the regulation of islet function, and therefore are potential therapeutic targets. This is evident from the recent success of glucagon-like peptide 1 (GLP1) mimetics and dipeptidyl peptidase 4 (DPP4) inhibitors, which promote activation of the GLP1 receptor to stimulate insulin secretion and inhibit glucagon secretion, and also have the potential to increase beta-cell mass. Other islet beta-cell GPCRs that are involved in the regulation of islet function include the glucose-dependent insulinotropic peptide (GIP) receptor, lipid GPCRs, pleiotropic peptide GPCRs and islet biogenic amine GPCRs. This Review summarizes islet GPCR expression, signalling and function, and highlights their potential as targets for the treatment of type 2 diabetes
