Persistent Staphylococcus aureus Colonization Is Not a Strongly Heritable Trait in Amish Families

About 20% of adults are persistently colonized with S. aureus in the anterior nares. Host genetic factors could contribute susceptibility to this phenotype. The objective of this study was to determine whether the phenotype of persistent S. aureus colonization aggregates in family members who live in different households. Healthy adults and their eligible same sex siblings who lived in different households were recruited from the Old Order Amish of Lancaster, Pennsylvania. All participants had two cultures of the anterior nares to determine if they were persistently colonized with S. aureus. Three hundred and ninety eight participants finished the study, of whom 166 were index cases and 232 were siblings of index cases. Eighteen per cent (71/398) of all participants and 17% (29/166) of index cases were persistently colonized with S. aureus. Twenty two per cent (8/36) of siblings of persistently colonized index cases were persistently colonized with S. aureus compared to 17% (34/196) of siblings of non-persistently colonized index cases, yielding a prevalence rate ratio of 1.28 (95% CI: 0.65–2.54, p = 0.64) and sibling relative risk of 1.25 (95% CI: 0.65–2.38, p = 0.51). The heritability of persistent colonization was 0.19±0.21 (p = 0.31). Persistent S. aureus colonization does not strongly aggregate in Amish family members in different households and heritability is low, suggesting that environmental factors or acquired host factors are more important than host genetic factors in determining persistent S. aureus colonization in this community

Boyongan and bayugo porphyry copper-gold deposits NE Mindanao, Philippines:Geology, geochemistry, and tectonic evolution

The recently-discovered Boyongan and Bayugo porphyry copper-gold deposits are part of an emerging belt of intrusion-centered gold-rich deposits in the Surigao district of NE Mindanao, Philippines. Since their formation in the Mid-Pliocene, exhumation and weathering of these deposits has lead to the development of a 600-m thick oxidation profile at Boyongan, and a modest(30-70m) oxidation profile at Bayugo. debris flows, volcanic material, and fluvio-lacustrine sediments accumulating in the actively extending Mainit graben subsequently covered the weathered deposits, preserving the supergene profiles

Metal transport and ore deposition in porphyry copper ± gold ± molybdenum deposits - contrasting behaviour between deep and shallow environments

High-grade zones typically develop in the Ksilicate- altered centre of porphyry deposits, where copper ± gold ± molybdenum are localised in and around the apex of the intrusion. Mineralisation develops in spatial and temporal association with abundant quartz ± magnetite ± orthoclase ± biotite ± anhydrite as veins, breccia cement and alteration minerals. Multiple generations of stockwork veins ± magmatic-hydrothermal breccias are common and provide evidence for repeated cycles of fluid release from the magma reservoir. Unmixing of brines and vapours from supercritical fluids (deep-level porphyries) and/or direct exsolution of these two phases from the intrusive complex (shallow-level porphyries) are essential prerequisites to ore formation. The brines contain most or all of the oreforming components, and have densities that restrict their occurrence to the apex and shoulders of the mineralising intrusion, where potassic alteration and mineralisation occurs. The vapour passes through the mineralised centre of porphyry deposits, ascending rapidly to the nearsurface environment, where it may form a lithocap

Geology of the Boyongan and Bayugo porphyry Cu-Au deposits: an emerging porphyry district in Northeast Mindanao, Philippines

The Boyongan and Bayugo porphyry Cu-Au mineral deposits, discovered under postmineralization cover during the previous decade, are part of an emerging belt of intrusion-centered Au-rich Cu mineral deposits and prospects in the Surigao district of northeast Mindanao, Philippines. Since their formation in the early Pleistocene, exhumation and weathering of these deposits have led to the development of a 600-m-thick oxidation profile at Boyongan and a modest (30–70 m) oxidation profile at Bayugo. Debris flows, volcanic material, and fluviolacustrine sediments accumulating in the actively extending Mainit graben subsequently covered the weathered deposits, preserving their supergene profiles.The mineral deposits formed in association with a composite diorite complex containing at least 12 discrete intrusive stages. Three premineralization diorite porphyry stocks and a silt-sand matrix breccia complex represent early stages of magmatism and brecciation. Significant Cu and Au introduction followed these events and occurred in association with small early-mineralization diorite porphyry stocks at Boyongan and Bayugo. Within the diorite complex, the two mineral deposits are spatially distinct, separated by approximately 1 km of premineralization diorites. Inter- and late-mineralization intrusions were emplaced as the magmatic-hydrothermal system waned.A characteristic progression of vein and K silicate alteration styles affected each of the synmineralization intrusions. Rare comb quartz unidirectional solidification textures (stage 0) mark the transition from magmatic to hydrothermal conditions. Quartz-poor wispy magnetite-biotite-K-feldspar veinlets characterize stage 1. Stage 2 veins consist of quartz with selvage and/or disseminated magnetite or biotite and K-feldspar halos. Stage 3 quartz veins have K-feldspar halos but generally lack magnetite and biotite. Stage 4 veins consist of massive bornite-chalcopyrite and chalcopyrite-pyrite with K-feldspar halos. Stage 3 quartz veins and stage 4 sulfide veins host Cu-Au mineralization of the greatest volumetric significance, reflecting the general paucity of sulfide in the earlier vein stages. Despite the simplicity of this sequence, detailed paragenetic reconstructions reveal that this characteristic progression of veining and K silicate alteration was repeated with the emplacement of each synmineralization intrusive event, revealing multiple magmatic-hydrothermal cycles of alteration and mineralization.At Boyongan and Bayugo, intense and pervasive illite alteration, in association with pyrite, chalcopyrite, and tetrahedrite-tennantite, developed in narrow structures crosscutting quartz-K-feldspar veins. Debris flows in the burial sequence above and adjacent to the Boyongan/Bayugo complex also contain abundant clasts with intense, pervasive illite and alunite-pyrophyllite-dickite-kaolinite alteration assemblages that have overprinted K silicate-style quartz veins.In both mineral deposits, Cu and Au are associated with intense quartz-vein stockworks composed primarily of K silicate stage 3 veins. Despite this association, not all of these quartz-vein stockworks contain Cu and Au to the same tenor. Quartz-vein stockworks in the eastern high grade of Boyongan have been intersected over a vertical interval of 800 m, having affected much of the early-mineralization stock. However, hypogene Cu grades exceed 0.5% by weight only in the upper 300 m of the stockwork (in the cupola of the early-mineralization stock). Superior grade development in high-grade zones at Boyongan, locally exceeding 2% Cu and 3 g/t Au, developed where fertile vein stages from two or more magmatic-hydrothermal cycles affected the same wall rock.The documented paragenetic relationships demonstrate multiple discrete cycles of K silicate-stage veining and alteration associated with each synmineralization intrusive event. All such events predate formation of feldspar-destructive illite-smectite-chlorite, illite-pyrite, and quartz-alunite-clay assemblages. Existing geochronological constraints on the timing of magmatism and hydrothermal activity demonstrate that these repeated cycles supporting superior grade development transpired extremely rapidly, in a period of less than 200,000 years (2.3–2.1 Ma). Geologic and geochronological constraints on the life cycle of Boyongan and Bayugo describe an extremely dynamic history of emplacement, exhumation, weathering, and burial over a period of 2.3 m.y. The study illustrates the spectrum of metallogenic processes operative over a geologically brief period and highlights some of the key elements responsible for formation of superior grades and for deposit preservation in an extensional setting.</p

From crucible to graben in 2.3 Ma: A high-resolution geochronological study of porphyry life cycles, boyongan-bayugo copper-gold deposits, Philippines

The Boyongan and Bayugo porphyry copper-gold deposits are part of a belt of gold-rich copper deposits in the Surigao district of northeast Mindanao, Philippines. The detailed age relationships described in this study provide insight into the geologically short life cycles that characterize porphyry formation in dynamic arc environments. Since their late Pliocene emplacement (2.3-2.1 Ma; SHRIMP [sensitive highresolution ion microprobe] U-Pb zircon dating) at depths of 1.2-2.0 km, these deposits were exhumed, deeply weathered, and buried. Weathering of these deposits led to the development of the world's deepest known porphyry oxidation profile (600 m thick) at Boyongan, and a modest (30-70 m) oxidation profile at adjacent Bayugo. This earlymiddle Pleistocene supergene event followed a period of rapid uplift and exhumation in northeast Mindanao (2.5 km/Ma; [U-Th]/He apatite age-elevation spectrum). Subsequent rapid subsidence (≥0.34 km/Ma; radiocarbon age-elevation spectrum) and burial of these deposits are attributed to a mid-Pleistocene shift from transpressional tectonics to the present-day transtensional setting in northeast Mindanao. During this period, debris flows, volcanic material, and fluviolacustrine sediments accumulating in the actively extending Mainit graben covered the weathered deposits, preserving the supergene profiles beneath 50-500 m of cover. This detailed geochronological study documents the geologically short (<2.3 Ma) time scales over which these major intrusion-centered mineral deposits evolved from emplacement, exhumation, deep oxidation, and burial, highlighting the dynamism of tectonic processes in environments such as the Philippine Mobile Belt. © 2012 Geological Society of America