In-depth cardiovascular and pulmonary assessments in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: A case series study

We assessed PET-CT myocardial blood flow (MBF) using N-13 ammonia, brachial flow-mediated dilation, and cardiopulmonary exercise test in five post-discarged MIS-C survivors. None of the patients (median age: 9, range: 7-18 years; 3 females; 2 males) had preexisting pediatric chronic conditions. At the follow-up visit, two patients exhibited severe perfusion defect developed in the left ventricular cavity, suggesting extensive myocardial ischemia (MBF <2.0) and one patient showed persistent mild pericardial effusion. Others two patients demonstrated endothelial dysfunction. Nevertheless, all patients had lower predicted values in the VO2peak, VO2VAT, OUES, and O2 Pulse (range: 35.2%–64.5%; 15.6%–38.2%; 1.0–1.3 L/min; 4–7 ml/beat), respectively. Our d suggested that previously health MIS-C patients had impaired MBF, endothelial dysfunction and lower cardiopulmonary capacity at follow-up analysis. Multidisciplinary further investigations should be conducted to reinforce these findings

Ergoespirometria em indivíduos com escoliose idiopática

Escoliose idiopática é uma disfunção na coluna vertebral que tende a diminuir os diâmetros, a flexibilidade e a excursão da caixa torácica, com possíveis efeitos deletérios na função pulmonar. O objetivo deste estudo foi verificar se há relação entre o grau de curvatura escoliótica e a função pulmonar e capacidade de exercício em indivíduos com escoliose idiopática de grau leve e moderado. Dezessete indivíduos com escoliose idiopática leve e moderada e 19 controles foram submetidos a teste pulmonar em repouso e exercício em esteira. As médias das variáveis pulmonares em repouso encontraram-se dentro da normalidade nos dois grupos; as variáveis de exercício consumo de oxigênio de pico (p=0,81), tempo de exercício (p=0,68), freqüência cardíaca (p=0,39), ventilação minuto (p=0,82), produção de dióxido de carbono (p=0,95), quociente respiratório (p=0,09), equivalente ventilatório para o oxigênio (p=0,90), lactato sangüíneo (p=0,98) não mostraram diferença estatisticamente significante entre os grupos. Não foi possível estabelecer relação de causa e efeito entre o grau de escoliose, função pulmonar e capacidade aeróbia, sugerindo que a escoliose não implica necessariamente perdas funcionais, sendo o treinamento uma importante medida de prevenção.Idiopathic scoliosis is a disorder of the spine that tends to reduce rib cage diameter, flexibility, and excursion, which might affect pulmonary function. The purpose here was to assess whether there is a relationship between the degree of scoliosis and pulmonary function and exercise capacity in subjects with mild to moderate idiopathic scoliosis. Seventeen subjects with mild to moderate idiopathic scoliosis and 19 controls underwent lung test at rest and during exercise on a treadmill. Mean pulmonary variables at rest were within normal parameters in both groups; during exercise, oxygen uptake (p=0.81), exercise time (p=0.68), heart rate (p=0,39), minute ventilation (p=0.82), carbon dioxide production (p=0.95), respiratory quotient (p=0.09), ventilatory equivalent for oxygen (p=0.90), and blood lactate concentration (p=0.98) did not show statistically significant differences between the groups. No cause-effect relationship could be established between the degree of scoliosis, pulmonary function and aerobic capacity, thus showing that scoliosis does not necessarily imply functional loss, and pointing to training as an important preventive measure