13 research outputs found
The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry
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All-carbon multi-electrode array for real-time in vitro measurements of oxidizable neurotransmitters
No full textMeasuring synaptic vesicles using cellular electrochemistry and nanoscale molecular imaging
No full textAmperometry methods for monitoring vesicular quantal size and regulation of exocytosis release
No full textMeasurement of natural variation of neurotransmitter tissue content in red harvester ant brains among different colonies
No full textQuantifying neurotransmitter secretion at single-vesicle resolution using high-density complementary metal–oxide–semiconductor electrode array
No full textDrug Transporters
No full textMembrane transporters perform a central function in many essential body functions, including traffic and compartmentalization of physiologic compounds, absorption of physiologic compounds (and, occasionally, structurally related xenobiotics, including drugs), and protection from potentially toxic exogenous compounds, which includes limiting their absorption and/or distribution and promoting their elimination (with no chemical modifications or as metabolites). The impact of drug biotransformation enzymes on pharmacokinetics and clinical outcome is much better understood than that of drug transporters, possibly due to the earlier discovery of metabolizing enzymes. The science of drug transporters can still be described as an emerging field, with knowledge on their structure, function, and regulation being continuously expanded.Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - La Plata; ArgentinaFil: Bellera, Carolina Leticia. Universidad Nacional de La Plata. Facultad de Ciencas Exactas. Laboratorio de Investigación y Desarrollo de Bioactivos; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - La Plata; ArgentinaFil: Pesce, Guido Oscar. Ministerio de Salud. Administración Nacional de Medicamentos, Alimentos y TecnologÃa Médica. Instituto Nacional de Medicamentos; Argentin
Simulations of amperometric monitoring of exocytosis: moderate pH variations within the cell-electrode cleft with the buffer diffusion
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