13 research outputs found
Transcriptomic analysis reveals specific osmoregulatory adaptive responses in gill mitochondria-rich cells and pavement cells of the Japanese eel
Full text linkActivation of H<sub>2</sub>O<sub>2</sub>-Induced VSOR Cl<sup>-</sup> Currents in HTC Cells Require Phospholipase Cγ1 Phosphorylation and Ca<sup>2+</sup> Mobilisation
No full textBinding of the protein ICln to α-integrin contributes to the activation of IClswell current
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Activation of volume-sensitive outwardly rectifying chloride channel by ROS contributes to ER stress and cardiac contractile dysfunction: involvement of CHOP through Wnt
No full textSocio-economic status and dietray habits in the elederly: results form a large random survey
No full textIon Channels Involved in Cell Volume Regulation: Effects on Migration, Proliferation, and Programmed Cell Death in Non Adherent EAT Cells and Adherent ELA Cells
No full textVRACs and other ion channels and transporters in the regulation of cell volume and beyond
No full textCells need to regulate their volume to counteract osmotic swelling or shrinkage, as well as during cell division, growth, migration and cell death. Mammalian cells adjust their volume by transporting potassium, sodium, chloride and small organic osmolytes using plasma membrane channels and transporters. This generates osmotic gradients, which drive water in and out of cells. Key players in this process are volume-regulated anion channels (VRACs), the composition of which has recently been identified and shown to encompass LRRC8 heteromers. VRACs also transport metabolites and drugs and function in extracellular signal transduction, apoptosis and anticancer drug resistance
