A Recombinant Influenza A Virus Expressing Domain III of West Nile Virus Induces Protective Immune Responses against Influenza and West Nile Virus

West Nile virus (WNV) continues to circulate in the USA and forms a threat to the rest of the Western hemisphere. Since methods for the treatment of WNV infections are not available, there is a need for the development of safe and effective vaccines. Here, we describe the construction of a recombinant influenza virus expressing domain III of the WNV glycoprotein E (Flu-NA-DIII) and its evaluation as a WNV vaccine candidate in a mouse model. FLU-NA-DIII-vaccinated mice were protected from severe body weight loss and mortality caused by WNV infection, whereas control mice succumbed to the infection. In addition, it was shown that one subcutaneous immunization with 105 TCID50 Flu-NA-DIII provided 100% protection against challenge. Adoptive transfer experiments demonstrated that protection was mediated by antibodies and CD4+T cells. Furthermore, mice vaccinated with FLU-NA-DIII developed protective influenza virus-specific antibody titers. It was concluded that this vector system might be an attractive platform for the development of bivalent WNV-influenza vaccines

Sexual Narcissism and Infidelity in Early Marriage

There is theoretical reason to believe that narcissism is associated with infidelity. Yet, studies that have examined this association have yielded inconsistent results. Given that these inconsistencies may have emerged because prior studies used global assessments of narcissism that do not capture the extent to which the components of narcissism are activated in the sexual domain, the current research drew from two longitudinal studies of 123 married couples to examine the extent to which sexual narcissism predicted marital infidelity. Consistent with the idea that narcissism predicts sexual behavior when activated in the sexual domain, own sexual narcissism was positively associated with infidelity, controlling for own marital and sexual satisfaction, own globally-assessed narcissism, partner globally-assessed narcissism, and partner sexual narcissism. Helping to explain why this association emerged, further analyses demonstrated that it was driven by all four facets of sexual narcissism—sexual exploitation, grandiose sense of sexual skill, sexual entitlement (Study 1 only), and lack of sexual empathy (husbands only). Additionally, although partner sexual narcissism was unrelated to infidelity on average, partners’ grandiose sense of sexual skill and partners’ sexual entitlement (Study 2 only) were positively associated with infidelity, and partners’ lack of sexual empathy was negatively associated with infidelity (Study 2 only). These findings highlight the benefits of using domain-specific measures of sexual narcissism in research on sexual behavior and the benefits of using domain-specific measures of personality more generally