‘La Beauté’: Art and Dialogism in the Poetry of Baudelaire

Studies of Baudelaire’s poem ‘La Beauté’ have generally agreed that it has a key role to play in our understanding of his aesthetic theories, but have differed wildly in how this role is interpreted. The present study brings together arguments that see the speaker of the poem, Beauty, as a statue, along with those that understand the poem as being fundamentally ironic. Situating ‘La Beauté’ in the context of Baudelaire’s art criticism allows us to understand it as part of his engagement in debates within the visual arts. This gives us a new reading of Beauty’s claims as voicing the positions of neo-classical idealism, and specifically those of nineteenth-century academic theorists influenced by the eighteenth-century German inventor of art history, Winckelmann. Recognizing the importance of Winckelmann in approaching this poem sheds light on the rejection of movement and emotion that is pronounced by Beauty, and which contradict Baudelaire’s theoretical positions expressed elsewhere. The sonnet is thus incorporating the language of a speaker who is distinct from the lyric ‘je’ and cannot be reduced to a mask for him or a part of his divided self. This language and the position it expresses are framed within the sonnet, whose implicit irony leads to what Bakhtin calls double voicing. This approach offers a new reading of ‘La Beauté’ in formal terms as an example of Bakhtinian dialogism within lyric poetry

Diffusion-weighted Imaging as a Treatment Response Biomarker for Evaluating Bone Metastases in Prostate Cancer: A Pilot Study.

Purpose To determine the usefulness of whole-body diffusion-weighted imaging (DWI) to assess the response of bone metastases to treatment in patients with metastatic castration-resistant prostate cancer (mCRPC). Materials and Methods A phase II prospective clinical trial of the poly-(adenosine diphosphate-ribose) polymerase inhibitor olaparib in mCRPC included a prospective magnetic resonance (MR) imaging substudy; the study was approved by the institutional research board, and written informed consent was obtained. Whole-body DWI was performed at baseline and after 12 weeks of olaparib administration by using 1.5-T MR imaging. Areas of abnormal signal intensity on DWI images in keeping with bone metastases were delineated to derive total diffusion volume (tDV); five target lesions were also evaluated. Associations of changes in volume of bone metastases and median apparent diffusion coefficient (ADC) with response to treatment were assessed by using the Mann-Whitney test and logistic regression; correlation with prostate-specific antigen level and circulating tumor cell count were assessed by using Spearman correlation (r). Results Twenty-one patients were included. All six responders to olaparib showed a decrease in tDV, while no decrease was observed in all nonresponders; this difference between responders and nonresponders was significant (P = .001). Increases in median ADC were associated with increased odds of response (odds ratio, 1.08; 95% confidence interval [CI]: 1.00, 1.15; P = .04). A positive association was detected between changes in tDV and best percentage change in prostate-specific antigen level and circulating tumor cell count (r = 0.63 [95% CI: 0.27, 0.83] and r = 0.77 [95% CI: 0.51, 0.90], respectively). When assessing five target lesions, decreases in volume were associated with response (odds ratio for volume increase, 0.89; 95% CI: 0.80, 0.99; P = .037). Conclusion This pilot study showed that decreases in volume and increases in median ADC of bone metastases assessed with whole-body DWI can potentially be used as indicators of response to olaparib in mCRPC. Online supplemental material is available for this article