Clinicopathological and prognostic significance of HER-2/neu and VEGF expression in colon carcinomas

<p>Abstract</p> <p>Background</p> <p>HER-2/neu and VEGF expression is correlated with disease behaviors in various cancers. However, evidence for their expression in colon cancer is rather contradictory both for the protein expression status and prognostic value. HER-2/neu is found to participate in VEGF regulation, and has known correlation with VEGF expression in some tumors. In this study, we investigated HER-2/neu and VEGF expression in Chinese colon patients and explored whether there was any correlation between their expression patterns.</p> <p>Methods</p> <p>HER-2/neu and VEGF were investigated immunohistochemically using tumor samples obtained from 317 colon cancer patients with all tumor stages. Correlation of the degree of staining with clinicopathological parameters and survival was investigated.</p> <p>Results</p> <p>Positive expression rates of HER-2/neu and VEGF in colon cancer were 15.5% and 55.5% respectively. HER-2/neu expression was significantly correlated with tumor size and distant metastases (<it>P </it>< 0.05), but was not an independent prognostic marker of survival <it>(P > 0.05)</it>. Expression of VEGF was significantly correlated with tumor size, tumor stage, lymph node metastases, and distant metastases (<it>P </it>< 0.05). The 5-year survival rate in patients with negative and positive VEGF expression was 70.2% and 61.9% respectively; the difference was not statistically significant <it>(P = 0.146)</it>. No correlation between HER-2/neu and VEGF expression was detected (<it>P = </it>0.151).</p> <p>Conclusions</p> <p>HER-2/neu and VEGF are not important prognostic markers of colon cancer. The present results do not support any association between HER2/neu and VEGF expression in this setting.</p

An examination of the effect of autumn closing date on over-winter herbage production and spring yield

peer-reviewedAltering autumn management affects the herbage mass available in spring. An experiment was established to determine the effect of five autumn closing dates (CDs) on herbage production, herbage quality, leaf, stem and dead proportions and tiller density over winter. In the study 50% of the herbage available in spring was accounted for by autumn CD. Each 1 d extra a sward was closed from 25 September to 9 December increased herbage mass by 16 kg DM/ha in spring. Swards closed earlier (25 September–26 October) had consistently higher herbage masses in spring (1,301 kg DM/ha) compared to swards closed later (11 November–9 December; 703 kg DM/ha). Later closed swards had greater herbage quality compared to earlier closed swards (organic matter digestibility = 852 and 825 g/kg DM, respectively) due to increased stem and dead material in the grazing horizon of earlier closed swards. There was no effect of autumn CD on sward quality in the subsequent defoliation in spring. However, following the initial spring grazing there was an effect of autumn CD on subsequent grass growth rates; swards closed in October had a lower growth rate (33 kg DM/ha per day) compared to swards closed in November and early December (49 kg DM/ha per day). Results indicate that earlier autumn closing is beneficial to meet high-feed demand in spring but can affect sward quality and growth rates in spring