5 research outputs found
Characterization and biological evaluation of some novel pyrazolo[3’,4’:4,5]thieno[2,3-d]pyrimidin-8-ones synthesized via the Gewald reaction
The synthesis of substituted pyrazolo[3’,4’:4,5]thieno[2,3-d]pyrimidin-8-ones (IIIa–j) from 5-amino-3-methyl-1H-thieno[3,2-c]pyrazole-6-carbonitrile (II) is described. The key compound II was synthesized from (5-methyl--2,4-dihydro-3H-pyrazol-3-ylidene)malononitrile I via the Gewald reaction. The synthesis of the title compounds IIIa–j was accomplished by condensation of II with different aromatic aldehydes. The newly synthesized heterocyles were characterized by elemental analysis, IR, 1H-NMR, 13C-NMR and mass spectroscopic investigation. All the newly synthesized compounds were evaluated for antimicrobial activity against a variety of bacterial strains
An efficient, microwave-assisted, one-pot synthesis of novel 5,6,7,8-tetrahydroquinoline-3-carbonitriles
An efficient, microwave-assisted synthesis of novel 2-alkoxy-5,6,7,8--tetrahydroquinoline-3-carbonitriles, which have not hitherto been reported, via reactions of cyclohexanone and arylidene malononitriles in the corresponding alcohols in presence of sodium is described. All the newly synthesized compounds were characterized by the IR, 1H-NMR, 13C-NMR and mass spectrescopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities
JSCS–3751 Original scientific paper
Characterization and biological evaluation of some novel pyrazolo[3’,4’:4,5]thieno[2,3-d]pyrimidin-8-ones synthesized via the Gewald reactio