Il vincolo di affinità profonda. Verso una filosofia ambientale panpsichista

The article provides some arguments in favour of a panpsychist turn in environmental philosophy. It first explains why dualism remains a favoured polemical target for many environmental activists and theorists, even though the scientific/metaphysical paradigm of reference is now generally physicalist. It then points to some of the tribulations of environmental philosophy in juggling dualism and physicalism. It goes on to describes some of the strategies adopted by environmental philosophers to establish an axiologically-relevant ontological affinity between humans and non-humans, and notes how these strategies punctually (and more or less explicitly and plausibly) return to the recognition (or attribution) of mind or mental characteristics to non-humans. Such recognition is easy in the case of non-human animals, revisionist in the case of plants and living non-sentient entities in general, and mostly left unattended in the case of non-human, non-living entities like rocks. This leaves us with a patchy result whereby humans have a deep ontological affinity with only small and selected portions of the non-human. The paper then articulates the contours of an alternative panpsychist cosmos, in which everything has mind or mental characteristics, and thus has a most profound bond with humans. Finally, it sketches some questions for a panpsychist research program in environmental philosophy

"Climate Change and Moral Corruption"

In “A Perfect Moral Storm”, S. Gardiner claims that "the peculiar features of the climate change problem pose substantial obstacles to our ability to make the hard choices necessary to address it. Climate change is a perfect moral storm. One consequence of this is that, even if difficult ethical questions could be answered, we might still find it difficult to act. For the storm makes us extremely vulnerable to moral corruption". Here I comment on the notion of moral corruption. In particular, I discuss the issues of who is susceptible to it and of what sort of problem moral corruption is

Mechanically-based approach to non-local elasticity: Variational principles

AbstractThe mechanically-based approach to non-local elastic continuum, will be captured through variational calculus, based on the assumptions that non-adjacent elements of the solid may exchange central body forces, monotonically decreasing with their interdistance, depending on the relative displacement, and on the volume products. Such a mechanical model is investigated introducing primarily the dual state variables by means of the virtual work principle. The constitutive relations between dual variables are introduced defining a proper, convex, potential energy. It is proved that the solution of the elastic problem corresponds to a global minimum of the potential energy functional. Moreover, the Euler–Lagrange equations together with the natural boundary conditions associated to the total potential energy functional are established with variational calculus and they coincide with analogous relations already obtained by means of mechanical considerations. Numerical analysis of a tensile specimen has been introduced to show the capabilities of the proposed approach

Fractional multiphase hereditary materials: Mellin Transforms and Multi-Scale Fractances

The rheological features of several complex organic natural tissues such as bones, muscles as well as of complex artificial polymers are well described by power-laws. Indeed, it is well-established that the time-dependence of the stress and the strain in relaxation/creep test may be well captured by power-laws with exponent β ∈ [0, 1]. In this context a generalization of linear springs and linear dashpots has been introduced in scientific literature in terms of a mechanical device dubbed spring-pot. Recently the authors introduced a mechanical analogue to spring-pot built upon a proper arrangements of springs and dashpots that results in Elasto-Viscous (EV) materials, as β ∈ [0, 1/2] and Visco-Elastic ones, as β ∈ [1/2, 1]. In this paper the authors will discuss the rheological description of the presence of multiple material phases that is highlighted by a linear combination of power-laws in the relaxation function G(t) with different exponents. Such rehological model is represented by a linear combination of fractional derivatives with different order and the inverse relations have been formulated in terms of the complex method Mellin transform. Additionally an alternative representation of direct and inverse relations of multi-phase fractional hereditary materials based on the exact mechanical description of spring-pot element will be discussed in the course of the paper

Fractional differential equations of multiphase hereditary materials and exact mechanical models

Creep and relaxation tests, performed on various materials like polymers, rubbers and so on are well-tted by power-laws with exponent 2 [0; 1] (Nutting (1921), Di Paola et al. (2011)). The consequence of this observation is that the stress-strain relation of hereditary materials is ruled by fractional operators (Scott Blair (1947), Slonimsky (1961)). A large amount of researches have been performed in the second part of the last century with the aim to connect constitutive fractional relations with some mechanical models by means of fractance trees and ladders (see Podlubny (1999)). Recently, Di Paola and Zingales (2012) proposed a mechanical model that corresponds to fractional stress-strain relation with any real exponent and they have proposed a description of above model (Di Paola et al. (2012)). In this study the authors aim to extend the study to cases with more fractional phases and to fractional Kelvin-Voigt model of hereditariness

Nod2 Deficiency in mice is Associated with Microbiota Variation Favouring the Expansion of mucosal CD4+ LAP+ Regulatory Cells

Nucleotide-binding Oligomerization Domain-2 (NOD2) mutations are associated with an increased risk to develop Crohn's Disease. In previous studies, we have shown that Nod2-/- mice manifest increased proportion of Lamina Propria (LP) CD4+ LAP+ Foxp3- regulatory cells, when compared with Nod2+/+ mice, while CD4+ Foxp3 + regulatory cells were not affected. Here, we investigated the Nod2 gut microbiota, by 16S rRNA pyrosequencing, at steady state and after TNBS-colitis induction in mice reared separately or in cohousing, correlating the microbial profiles with LP regulatory T cells proportion and tissue cytokines content. We found that enrichment of Rikenella and Alistipes (Rikenellaceae) in Nod2-/- mice at 8 weeks of age reared separately was associated with increased proportion of CD4+ LAP+ Foxp3- cells and less severe TNBS-colitis. In co-housed mice the acquisition of Rickenellaceae by Nod2+/+ mice was associated with increased CD4+ LAP+ Foxp3- proportion and less severe colitis. Severe colitis was associated with enrichment of gram-negative pathobionts (Escherichia and Enterococcus), while less severe colitis with protective bacteria (Barnesiella, Odoribacter and Clostridium IV). Environmental factors acting on genetic background with different outcomes according to their impact on microbiota, predispose in different ways to inflammation. These results open a new scenario for therapeutic attempt to re-establish eubiosis in Inflammatory Bowel Disease patients with NOD2 polymorphisms

Integrated Biophysical Modeling of the SARS-CoV-2 Spike Protein Binding and Allosteric Interactions with Antibodies

Structural and biochemical studies of the severe acute respiratory syndrome (SARS)-CoV-2 spike glycoproteins and complexes with highly potent antibodies have revealed multiple conformation-dependent epitopes highlighting conformational plasticity of spike proteins and capacity for eliciting specific binding and broad neutralization responses. In this study, we used coevolutionary analysis, molecular simulations, and perturbation-based hierarchical network modeling of the SARS-CoV-2 spike protein complexes with a panel of antibodies targeting distinct epitopes to explore molecular mechanisms underlying binding-induced modulation of dynamics and allosteric signaling in the spike proteins. Through coevolutionary analysis of the SARS-CoV-2 spike proteins, we identified highly coevolving hotspots and functional clusters that enable a functional cross-talk between distant allosteric regions in the SARS-CoV-2 spike complexes with antibodies. Coarse-grained and all-atom molecular dynamics simulations combined with mutational sensitivity mapping and perturbation-based profiling of the SARS-CoV-2 receptor-binding domain (RBD) complexes with CR3022 and CB6 antibodies enabled a detailed validation of the proposed approach and an extensive quantitative comparison with the experimental structural and deep mutagenesis scanning data. By combining in silico mutational scanning, perturbation-based modeling, and network analysis of the SARS-CoV-2 spike trimer complexes with H014, S309, S2M11, and S2E12 antibodies, we demonstrated that antibodies can incur specific and functionally relevant changes by modulating allosteric propensities and collective dynamics of the SARS-CoV-2 spike proteins. The results provide a novel insight into regulatory mechanisms of SARS-CoV-2 S proteins showing that antibody-escaping mutations can preferentially target structurally adaptable energy hotspots and allosteric effector centers that control functional movements and allosteric communication in the complexes