Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective

The incidence of cerebrovascular disease is highest in the elderly population. However, the pathophysiological mechanisms of brain response to cerebral ischemia in old age are currently poorly understood. Ischemic changes in the commonly used young animal stroke models do not reflect the molecular changes associated with the aged brain. Neuroinflammation and oxidative stress are important pathogenic processes occurring during the acute phase of cerebral ischemia. Free radical generation is also implicated in the aging process, and the combination of these effects in elderly stroke patients could explain the higher risk of morbidity and mortality. A better understanding of stroke pathophysiology in the elderly patient would assist in the development of new therapeutic strategies for this vulnerable age group. With the increasing use of reperfusion therapies, inflammatory pathways and oxidative stress remain attractive therapeutic targets for the development of adjuvant neuroprotective agents. This paper will discuss these molecular aspects of acute stroke and senescence from a bench-to-bedside research perspective

Multistage Switching Architectures for Software Routers

Software routers based on personal computer (PC) architectures are becoming an important alternative to proprietary and expensive network devices. However, software routers suffer from many limitations of the PC architecture, including, among others, limited bus and central processing unit (CPU) bandwidth, high memory access latency, limited scalability in terms of number of network interface cards, and lack of resilience mechanisms. Multistage PC-based architectures can be an interesting alternative since they permit us to i) increase the performance of single software routers, ii) scale router size, iii) distribute packet manipulation and control functionality, iv) recover from single-component failures, and v) incrementally upgrade router performance. We propose a specific multistage architecture, exploiting PC-based routers as switching elements, to build a high-speed, largesize,scalable, and reliable software router. A small-scale prototype of the multistage router is currently up and running in our labs, and performance evaluation is under wa

A rapid review of time management strategies among nurse managers

Background: Time management practice is the act of influencing one's behavioural dimensions to complete as many tasks as possible within a specified amount of time. These behavioural dimensions include work organization and the continued application of time management techniques. Good time management, such as setting goals and priorities, as well as planning and delegating tasks, can facilitate productivity and success, contributing to work effectiveness, maintaining balance and job satisfaction. Conversely, poor time management has been associated with poor quality of work, low productivity, negative influence on the career path, and high levels of stress. Aim: The study aims to identify the strategies used by middle nurse managers in time management. Methods: A rapid review of biomedical databases was undertaken during the month of June 2021. The included studies were published in English and in Italian. Results: Findings reveal that the most used and effective time management strategies for nurse managers are setting goals, and priorities and delegating tasks. Other useful strategies also found to be fundamental are discussed in detail. Conclusion: A manager should prioritize the concept of planning, which can be counted as an efficient time management technique and educate himself on delegating. Time management has an impact not only on productivity and organizational success, but also on the balance between private and working life of managers

Anthropogenic sinkholes in the Marsala area (western Sicily) linked to underground quarries

Marsala territory (western Sicily) is characterized by the presence of a Lower Pleistocene (Calabrian) calcarenite succession (Marsala Calcarenite Fm). It can be divided into three lithofacies that show the regressive evolution of the depositional system: a) coarse to fine yellow bio- and lithoclastic calcarenites, b) sands, and c) gray sandy clays. At least 80 m-thick, this succession gently dips (5-10) towards the south and the south-west. At some locations the Marsala Calcarenite is covered by Middle and Upper Pleistocene marine terraced deposits. Since the Roman period, due to the great abundance of calcarenite rocks, and to the facility of extraction, the Marsala area has been characterized by a high number of quarries for the extraction of this building materials. Many of them were excavated underground, at depth varying from a few meters to about 25 m, and are arranged in one or two levels, following the galleries and pillars excavation technique. With time, the underground quarries have been progressively abandoned for the decay of the physical and mechanical properties of the calcarenite rock mass, the interaction with the groundwater, the high costs of extraction, and the dangers and difficulties encountered in working underground. Since the 1960’s the quarries have been affected by instability processes, visible through collapses and deformations of vaults and pillars. These phenomena often propagate upward reaching the topographic surface and forming sinkholes which affect and severely damage the built-up area. In particular, two case studies of sinkholes related to different underground quarries will be analyzed in this paper. The aim is to provide a description of the most significant processes and factors responsible of the instability processes based on field surveys, as well as to understand the generation mechanisms of these anthropogenic sinkholes by means of numerical modeling, based on rock laboratory testing data, that represents in these cases a remarkable tool for the investigation of the cause-effect relationships, as already performed in other areas of Italy

Facial nerve paralysis in acute otomastoiditis as presenting symptom of FAB M2, T8;21 leukemic relapse. Case report and review of the literature

Granulocytic sarcoma (chloroma) is a rare solid, extramedullary tumour composed of immature granulocytes, occurring during granulocytic leukemia. Leukemic involvement of the temporal bone is not uncommon and may present in a variety of ways. Symptomatic facial nerve paralysis is one of these. The authors report a case of facial nerve paralysis as the presenting symptom of leukemic relapse in a 16-year-old white male, affected by acute myelogenous leukemia FAB M2, karyotype 46xy, T8;21