La qualità alessitimica nelle dipendenze

In questa ricerca proponiamo l'osservazione del legame tra alessitimia ed acting out nel contesto della dipendenza che diventa l'agito al quale l'individuo può ricorrere per evacuare gli stati dolorosi interni, attraverso il rapporto compulsivo con la sostanza. Per poter tollerare affetti altrimenti irrapresentabili ed ingestibili il soggetto può infatti cercare sostegno nel paradosso tossicomanico, dove la gestione emotiva avviene nella dolorosa non-elaborazione con strategie efficaci

Uso problematico dello smartphone e psicopatologia in adolescenza

La straordinaria diffusione dello smartphone a livello globale ha comportato molteplici aspetti positivi, ma una vasta letteratura scientifica rileva stabilmente che un uso eccessivo dello smartphone comporta aspetti problematici ed effetti dannosi sulla vita delle persone, con profonde implicazioni sulla loro salute fisica e mentale. La categoria maggiormente vulnerabile all'uso problematico dello smartphone è rappresentata dagli adolescenti, che lo usano con un'elevata competenza tecnica, ma con scarsa capacità critica e che, con maggiore facilità, possono orientarsi verso un uso smodato e patologico. L'uso sregolato dello smartphone determina un aumento dei fallimenti scolastici ed è correlato con l'incremento di psicopatologie, in particolare disturbi d'ansia e disturbi depressivi

Acute small bowel obstruction caused by endometriosis: A case report and review of the literature

Gastrointestinal involvement of endometriosis has been found in 3%-37% of menstruating women and exclusive localization on the ileum is very rare (1%-7%). Endometriosis of the distal ileum is an infrequent cause of intestinal obstruction, ranging from 7% to 23% of all cases with intestinal involvement. We report a case in which endometrial infiltration of the small bowel caused acute obstruction requiring emergency surgery, in a woman whose symptoms were not related to menses. Histology of the resected specimen showed that endometriosis was mainly prevalent in the muscularis propria and submucosa and that the mucosa was not ulcerated but had inflammation and glandular alteration. Endometrial lymph node involvement, with a cystic glandular pattern was also detected

Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes

To shed light into the molecular bases of B-lineage acute lymphoblastic leukemia lacking known fusion transcripts, i.e. BCR-ABL1, ETV6-RUNX1, E2A-PBX1, and MLL rearrangements (B-NEG ALL) and the differences between children, adolescents/young adults (AYA) and adults, we analyzed 168 B-NEG ALLs by genome-wide technologies. This approach showed that B-NEG cases carry 10.5 mutations and 9.1 copy-number aberrations/sample. The most frequently mutated druggable pathways were those pertaining to RAS/RTK (26.8%) and JAK/STAT (12.5%) signaling. In particular, FLT3 and JAK/STAT mutations were detected mainly in AYA and adults, while KRAS and NRAS mutations were more frequent in children. RAS/RTK mutations negatively affected the outcome of AYA and adults, but not that of children. Furthermore, adult B-NEG ALL carrying JAK/STAT mutations had a shorter survival. In vitro experiments showed that FLT3 inhibitors reduced significantly the proliferation of FLT3-mutated primary B-NEG ALL cells. Likewise, PI3K/mTOR inhibitors reduced the proliferation of primary cells harboring RAS and IL7R mutations. These results refine the genetic landscape of B-NEG ALL and suggest that the different distribution of lesions and their prognostic impact might sustain the diverse outcome between children, adults and partly AYA - whose genomic scenario is similar to adults - and open the way to targeted therapeutic strategies