17 research outputs found
Light Higgsino from Axion Dark Radiation
The recent observations imply that there is an extra relativistic degree of
freedom coined dark radiation. We argue that the QCD axion is a plausible
candidate for the dark radiation, not only because of its extremely small mass,
but also because in the supersymmetric extension of the Peccei-Quinn mechanism
the saxion tends to dominate the Universe and decays into axions with a sizable
branching fraction. We show that the Higgsino mixing parameter mu is bounded
from above when the axions produced at the saxion decays constitute the dark
radiation: mu \lesssim 300 GeV for a saxion lighter than 2m_W, and mu less than
the saxion mass otherwise. Interestingly, the Higgsino can be light enough to
be within the reach of LHC and/or ILC even when the other superparticles are
heavy with mass about 1 TeV or higher. We also estimate the abundance of axino
produced by the decays of Higgsino and saxion.Comment: 18 pages, 1 figure; published in JHE
Maternal Undernutrition Significantly Impacts Ovarian Follicle Number and Increases Ovarian Oxidative Stress in Adult Rat Offspring
BACKGROUND: We have shown recently that maternal undernutrition (UN) advanced female pubertal onset in a manner that is dependent upon the timing of UN. The long-term consequence of this accelerated puberty on ovarian function is unknown. Recent findings suggest that oxidative stress may be one mechanism whereby early life events impact on later physiological functioning. Therefore, using an established rodent model of maternal UN at critical windows of development, we examined maternal UN-induced changes in offspring ovarian function and determined whether these changes were underpinned by ovarian oxidative stress. METHODOLOGY/PRINCIPAL FINDINGS: Our study is the first to show that maternal UN significantly reduced primordial and secondary follicle number in offspring in a manner that was dependent upon the timing of maternal UN. Specifically, a reduction in these early stage follicles was observed in offspring born to mothers undernourished throughout both pregnancy and lactation. Additionally, antral follicle number was reduced in offspring born to all mothers that were UN regardless of whether the period of UN was restricted to pregnancy or lactation or both. These reductions were associated with decreased mRNA levels of genes critical for follicle maturation and ovulation. Increased ovarian protein carbonyls were observed in offspring born to mothers UN during pregnancy and/or lactation and this was associated with peroxiredoxin 3 hyperoxidation and reduced mRNA levels; suggesting compromised antioxidant defence. This was not observed in offspring of mothers UN during lactation alone. CONCLUSIONS: We propose that maternal UN, particularly at a time-point that includes pregnancy, results in reduced offspring ovarian follicle numbers and mRNA levels of regulatory genes and may be mediated by increased ovarian oxidative stress coupled with a decreased ability to repair the resultant oxidative damage. Together these data are suggestive of maternal UN potentially contributing to premature ovarian ageing in offspring
The role of leptin in the respiratory system: an overview
Since its cloning in 1994, leptin has emerged in the literature as a pleiotropic hormone whose actions extend from immune system homeostasis to reproduction and angiogenesis. Recent investigations have identified the lung as a leptin responsive and producing organ, while extensive research has been published concerning the role of leptin in the respiratory system. Animal studies have provided evidence indicating that leptin is a stimulant of ventilation, whereas researchers have proposed an important role for leptin in lung maturation and development. Studies further suggest a significant impact of leptin on specific respiratory diseases, including obstructive sleep apnoea-hypopnoea syndrome, asthma, COPD and lung cancer. However, as new investigations are under way, the picture is becoming more complex. The scope of this review is to decode the existing data concerning the actions of leptin in the lung and provide a detailed description of leptin's involvement in the most common disorders of the respiratory system
First M87 Event Horizon Telescope Results. I. The Shadow of the Supermassive Black Hole
When surrounded by a transparent emission region, black holes are expected to reveal a dark shadow caused by
gravitational light bending and photon capture at the event horizon. To image and study this phenomenon, we have
assembled the Event Horizon Telescope, a global very long baseline interferometry array observing at a wavelength of
1.3 mm. This allows us to reconstruct event-horizon-scale images of the supermassive black hole candidate in the center
of the giant elliptical galaxy M87. We have resolved the central compact radio source as an asymmetric bright emission
ring with a diameter of 42 ± 3 μas, which is circular and encompasses a central depression in brightness with a flux
ratio 10:1. The emission ring is recovered using different calibration and imaging schemes, with its diameter and
width remaining stable over four different observations carried out in different days. Overall, the observed image is
consistent with expectations for the shadow of a Kerr black hole as predicted by general relativity. The asymmetry in
brightness in the ring can be explained in terms of relativistic beaming of the emission from a plasma rotating close to
the speed of light around a black hole. We compare our images to an extensive library of ray-traced general-relativistic
magnetohydrodynamic simulations of black holes and derive a central mass of M = (6.5 ± 0.7) × 109 Me. Our radiowave observations thus provide powerful evidence for the presence of supermassive black holes in centers of galaxies
and as the central engines of active galactic nuclei. They also present a new tool to explore gravity in its most extreme
limit and on a mass scale that was so far not accessible
First M87 Event Horizon Telescope Results. II. Array and Instrumentation
The Event Horizon Telescope (EHT) is a very long baseline interferometry (VLBI) array that comprises millimeter- and submillimeter-wavelength telescopes separated by distances comparable to the diameter of the Earth. At a nominal operating wavelength of ~1.3 mm, EHT angular resolution (λ/D) is ~25 μas, which is sufficient to resolve nearby supermassive black hole candidates on spatial and temporal scales that correspond to their event horizons. With this capability, the EHT scientific goals are to probe general relativistic effects in the strong-field regime and to study accretion and relativistic jet formation near the black hole boundary. In this Letter we describe the system design of the EHT, detail the technology and instrumentation that enable observations, and provide measures of its performance. Meeting the EHT science objectives has required several key developments that have facilitated the robust extension of the VLBI technique to EHT observing wavelengths and the production of instrumentation that can be deployed on a heterogeneous array of existing telescopes and facilities. To meet sensitivity requirements, high-bandwidth digital systems were developed that process data at rates of 64 gigabit s−1, exceeding those of currently operating cm-wavelength VLBI arrays by more than an order of magnitude. Associated improvements include the development of phasing systems at array facilities, new receiver installation at several sites, and the deployment of hydrogen maser frequency standards to ensure coherent data capture across the array. These efforts led to the coordination and execution of the first Global EHT observations in 2017 April, and to event-horizon-scale imaging of the supermassive black hole candidate in M87
Balancing research and funding using value of information and portfolio tools for nanomaterial risk classification
Leptin alters the structural and functional characteristics of adipose tissue before birth
This study aimed to determine for the first time whether leptin can act to alter the structural andfunctional characteristics of adipose tissue before birth. Leptin (0.48 mg/kg/day) or saline wasinfused intravenously into fetal sheep for 4 days from either 136 or 137 days of gestation(term=147±3 days). Circulating leptin concentrations were increased approximately four- tofivefold by leptin infusion. Leptin infusion resulted in a significant increase in the proportion ofsmaller lipid locules present within fetal perirenal adipose tissue (PAT), and this was associatedwith a significant increase in the proportion of multilocular tissue and a significant decrease inthe proportion and relative mass of unilocular tissue in fetal PAT. The relative abundance ofleptin mRNA in fetal PAT was significantly lower in the leptin-infused group, and there was apositive correlation between the relative abundance of leptin mRNA and the proportion ofunilocular adipose tissue in fetal PAT. The amount of uncoupling protein 1 tended to be higher(P=0.06) in leptin-infused compared with saline-infused fetuses. This is the first demonstrationthat leptin can act to regulate the lipid storage characteristics, leptin synthetic capacity, andpotential thermogenic functions of fat before birth
Influence of maternal pre-pregnancy body composition and diet during early-mid pregnancy on cardiovascular function and nephron number in juvenile sheep.
The prenatal diet can program an individual's cardiovascular system towards later higher resting blood pressure and kidney dysfunction, but the extent to which these programmed responses are directly determined by the timing of maternal nutritional manipulation is unknown. In the present study we examined whether maternal nutrient restriction targeted over the period of maximal placental growth, i.e. days 28-80 of gestation, resulted in altered blood pressure or kidney development in the juvenile offspring. This was undertaken in 6-month-old sheep born to mothers fed control (100-150 % of the recommended metabolisable energy (ME) intake for that stage of gestation) or nutrient-restricted (NR; 50 % ME; n 6) diets between days 28 and 80 of gestation. Controls were additionally grouped according to normal (>3, n 7) or low body condition score (LBCS; <2, n 6), thereby enabling us to examine the effect of maternal body composition on later cardiovascular function. From day 80 to term (approximately 147 d) all sheep were fed to 100 % ME. Offspring were weaned at 12 weeks and pasture-reared until 6 months of age when cardiovascular function was determined. Both LBCS and NR sheep tended to have lower resting systolic (control, 85 (se 2); LBCS, 77 (se 3); NR, 77 (se 3) mmHg) and diastolic blood pressure relative to controls. Total nephron count was markedly lower in both LBCS and NR relative to controls (LBCS, 59 (se 6); NR, 56 (se 12) %). Our data suggest that maternal body composition around conception is as important as the level of nutrient intake during early pregnancy in programming later cardiovascular health