A Cross-Linguistic Study of the Relationship between Grammar & Lexical Development

The relationship between grammatical and lexical development was compared in 233 English and 233 Italian children aged between 1;6 and 2;6, matched for age, gender, and vocabulary size on the MacArthur Communicative Development Inventories (CDI). Four different measures of Mean Length of Utterance were applied to the three longest utterances reported by parents, and to corrected/expanded versions representing the 'target' for each utterance. Italians had longer MLUs on most measures, but the ratio of actual to target MLUs did not differ between languages. Age and vocabulary both contributed significant variance to MLU, but the contribution of vocabulary was much larger, suggesting that vocabulary size may provide a better basis for crosslinguistic comparisons of grammatical development. The relationship between MLU and vocabulary size was non-linear in English but linear in Italian, suggesting that grammar 'gets off the ground' earlier in a richly inflected language. A possible mechanism to account for this difference is discussed

Expression of high- and low-affinity epidermal growth factor receptors in human hepatoma cell lines

AbstractData are presented from a comparative research on expression of epidermal growth factor (EGF) receptors and response to EGF of six independently established cell lines derived from human hepatoma. These lines differ in terms of the degree of differentiation, presence of hepatitis B virus (HBV) DNA copies in integrated form and expression of HBV genes. Our results indicate differential expression of membrane EGF receptors and differential response to EGF under serum- and hormone-free culture conditions. Furthermore, a significant difference in affinity could be detected between EGF receptors of the two highly dedifferentiated cell lines (HA22T/VGH and Li7A) whose replication is inhibited by EGF concentrations capable of stimulating more differentiated phenotypes

Short-Term Outcomes of an ESDM Intervention in Italian Children with Autism Spectrum Disorder following the COVID-19 Lockdown

The COVID-19 pandemic caused a temporary lockdown period in Italy, during which the delivery of in-person treatment for children with autism spectrum disorder (ASD) in public health services was discontinued. This occurrence represented a crucial challenge for both families and professionals. We assessed the short-term outcomes of a sample of 18 children who received an early intervention with the Early Start Denver Model (ESDM), delivered at low intensity over one year in the pre-pandemic period, after six months of interruption of in-presence treatment due to lockdown restrictions. Children who received the ESDM treatment maintained their gains in sociocommunicative skills and did not exhibit any developmental regression. Additionally, there was evidence of a decrease in the restrictive and repetitive behavior (RRB) domain. The parents, who were already familiar with the principles of the ESDM, only received telehealth support from therapists that aimed to sustain the gains already achieved. We believe that it is always helpful to support parents in their daily lives by implementing interactional and play skills with their children to integrate and consolidate the results obtained in the individual interventions conducted by experienced therapists

New On Line Resource for Psycholinguistic

Picture naming is a widely used technique in psycholinguistic studies. Here, we describe new on-line resources that our project has compiled and made available to researchers on the world wide web at http://crl.ucsd.edu/~aszekely/ipnp/. The website provides access to a wide range of picture stimuli and related norms in seven languages. Picture naming norms, including indices of name agreement and latency, for 520 black-and-white drawings of common objects and 275 concrete transitive and intransitive actions are presented. Norms for age-of-acquisition, word-frequency, familiarity, goodness-of-depiction, and visual complexity are included. An on-line database query system can be used to select a specific range of stimuli, based on parameters of interest for a wide range of studies on healthy and clinical populations, as well as studies of language development

Adattamento italiano del BRIEF-P Behavior Rating Inventory Of Executive Function. Preschool version.

Valutazione precoce: costruito per rilevare il comportamento di bambini di età compresa tra i 2 e i 5 anni, il BRIEF-P offre la possibilità di un assessment strutturato del funzionamento esecutivo in una fascia di età molto precoce, massimizzando l’opportunità di rilevare carenze e difficoltà e di intervenire tempestivamente. Focalizzazione sui comportamenti nei contesti di vita: la struttura a questionario consente di sistematizzare la frequenza di comportamenti agiti dal bambino nella vita di tutti i giorni; la compilazione indipendente da parte di insegnanti o genitori, permette di registrare informazioni sulle manifestazioni delle funzioni esecutive in contesti diversi, particolarmente utili a livello clinico e diagnostico. Vasta letteratura di riferimento e trial clinici: il BRIEF-P è utilizzato in tutto il mondo per la particolare combinazione tra agilità e affidabilità nei più diversi trial clinici, proprio perché può contare su una corposa letteratura a supporto della sua riconosciuta e condivisa validità, e quindi essere applicato sia per la diagnosi clinica che per la valutazione degli esiti in un ampio range di condizioni di sviluppo atipico