ALDOSTERONE SECRETION AND PRIMARY AND MALIGNANT HYPERTENSION

After the synthesis of desoxycorticosterone (DOC), it became apparent that this cortico-steroid, the physiological effects of which are con-cerned primarily with sodium and potassium me-tabolism, can produce a state of hypertension both in animals and in man (1, 2). The induced hy-pertension is dependent upon the administration of adequate amounts of dietary sodium, whereas the hypertensive state, produced by administra-tion of glucocorticoids such as cortisone, differs in that it is independent of the dietary sodium content (3). More recently, following the chemical and bio-logical characterization of the mineralocorticoid hormone, aldosterone (4), a disease state associ-ated with primary hypersecretion of this hormone has been described in man (5). Aldosterone pro-duces effects on sodium and potassium metabolism similar to those of desoxycorticosterone, and the clinical syndrome of primary aldosteronism re-sembles the disease state produced by chronic ad-ministration of DOC to dogs (6). Arterial hy-pertension has been a consistent finding in pa-tients with primary hyperaldosteronism. A number of other observations have suggested a relationship between the dietary sodium intake and the blood pressure level of patients with pri-mary (benign essential) hypertension. The bene-ficial effects of sodium deprivation, and of various natriuretic agents in certain patients with hyper-tension, is well known. In addition, other stud-ies have suggested that abnormalities of intracel-lular sodium and potassium content may occur in patients with arterial hypertension (7). Genest, Koiw, Nowaczynski and Lebouef (8) have re

TREATMENT OF NEPHROSIS WITH PITUITARY ADRENOCORTICOTROPHIN 1

The administration of pituitary adrenocorticotrophin (ACTH) to patients with nephrosis has been reported to initiate diuresis in a large proportion of cases (1-6). Since this diuresis may occu

ARES. III. Unveiling the Two Faces of KELT-7 b with HST WFC3

We present the analysis of the hot-Jupiter KELT-7 b using transmission and emission spectroscopy from the Hubble Space Telescope (HST), both taken with the Wide Field Camera 3 (WFC3). Our study uncovers a rich transmission spectrum which is consistent with a cloud-free atmosphere and suggests the presence of H2O and H-. In contrast, the extracted emission spectrum does not contain strong absorption features and, although it is not consistent with a simple blackbody, it can be explained by a varying temperature-pressure profile, collision induced absorption (CIA) and H-. KELT-7b had also been studied with other space-based instruments and we explore the effects of introducing these additional datasets. Further observations with Hubble, or the next generation of space-based telescopes, are needed to allow for the optical opacity source in transmission to be confirmed and for molecular features to be disentangled in emission