A case of tracheobronchial amyloidosis presenting with acute myeloid leukemia

Localized tracheobronchial amyloidosis (TBA) is a rare form of pulmonary amyloidosis that is characterized by amyloidosis accumulation in the trachea and main bronchus submucosa. TBA is usually localized in the lung and is not associated with systemic amyloidosis. Although patients may be asymptomatic at first, they may develop dyspnea, recurrent cough, and hemoptysis attacks as the lesions narrow the tracheobronchial tree. Histochemical examination of biopsies taken with flexible bronchoscopy after thorax CT findings is usually used to make the diagnosis. There has never been a case reported in which TBA and acute myeloid leukemia (AML) coexisted. We report the first case of TBA in a patient diagnosed with AML

Ümitköy’ün kentleşme süreci

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2017.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Çekiç, Can Eyüp

Collaboration with Medical Education: Board Exams of Medical Specialist’ Associations

Objective: In Turkey, the boards were established in the last twenty years. Collaboration between boards and medical education discipline will lead board exams to be valid, reliable, acceptable, and fair. In this study, it is aimed to reveal the areas where boards can collaborate with the medical education discipline. Methods: A workshop was held within the scope of a congress held in İzmir in February 2020. In the workshop, it was aimed to raise awareness about the stages of board examination from planning to implementation and the knowledge and skills that board members should have. At the beginning of the workshop, participants were taken to the 5-station Objective Structured Clinical Examination (OSCE). OSCE stations evaluated participants’ characteristics, proficiency exam planning, question preparation, question evaluation, and problem-solving. A discussion session was conducted based on the basis of participant performances. The workshop was completed with a presentation on deciding the pass-fail score of an exam. Results: It was determined that the participants did not have information about board exams and were not involved in planning. It was determined that the participants could not write multiple-choice questions in accordance with the criteria and could not technically evaluate the prepared multiple-choice questions. At the problem-solving OSCE station where performance was evaluated, some participants could not use the time effectively and did not consider the rules. A session was held to decide the passing score of the OSCE that participants were included in. The Angoff technique was used and the scores determined by the participants were visualized, and the importance of reconciliation for the passing score was discussed. Conclusion: The workshop showed that there are areas that can be collaborated with the medical education discipline in planning and implementing board exams

Crystal structures, spectroscopic properties of new cobalt(II), nickel(II), zinc (II) and palladium(II) complexes derived from 2-acetyl-5-chloro thiophene thiosemicarbazone: Anticancer evaluation

The reactions of cobalt(II), nickel(II), zinc(II) chlorides and [Pd(DMSO)(2)Cl-2] with 2-acetyl-5-chloro-thiophene thiosemicarbazone (HL) leads to the formation of a series of new complexes: [CoCl2(S-HL)(2)], 1; [Ni(N,S-L)(2)], 2 [ZnCl2(S-HL)(2)], 3 and [PdCl2(N,S-HL)], 4. All the complexes have been characterized by elemental analysis, IR, LC-MS. H-1 and C-13 NMR spectroscopy have been performed for Zn(II) and Pd(II) complexes. The crystal structures of the complexes 1-3 have been determined by single-crystal X-ray diffraction methods. The compounds, (1) and (3), crystallized in the monoclinic crystal system with C2/c space group. In both complexes, the metal centers are fourcoordinated in a distorted tetrahedral configuration by two sulfur atoms from two thiosemicarbazone ligands and two Cl anions. The crystal structure of (2) consists of monomeric entities where the nickel(II) ion exhibit distorted square planar geometry. The coordination geometry around nickel ion is fourcoordinate with four atoms of the two chelating thiosemicarbazone ligands which are in cis position. The tau(4) value of 0.255 obtained from the tau(4) analysis of complex (2) shows that the fourcoordinate geometry around the central nickel ion is close to square planar. Complex (4) is mononuclear, the central ion is coordinated through the sulfur and the azomethine nitrogen atom of neutral ligand. The cytotoxic effects of all complexes were analyzed for three cancer cell lines, Caco-2, DLD-1, and SW620 compared to normal colon epithelial cell line, CCD18Co. Complex (4) is more active against DLD-1, SW620 and Caco-2 than CCD18Co. The efficiency of complex (4) is more effective in aggressive cancer cell lines. Therefore, it can be used as a new chemotherapeutic, especially in the treatment of resistant cancer types caused by long-term use of platinum-based drugs

Oligoarticular Juvenile Idiopathic Arthritis Does Not Show Signs Of T-Cell Exhaustion, In Spite Of Increased Expression Of Co-Inhibitory Receptors

Wo