Highlights in Resistance Mechanism Pathways for Combination Therapy

Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years. Although the mechanisms of action and signaling pathways affected by most treatments with single antineoplastic agents might be relatively well understood, most combinations remain poorly understood. This review presents the most common alterations of signaling pathways in response to cytotoxic and targeted anticancer drug treatments, with a discussion of how the knowledge of signaling pathways might support and orient the development of innovative strategies for anticancer combination therapy. The ultimate goal is to highlight possible strategies of chemotherapy combinations based on the signaling pathways associated with the resistance mechanisms against anticancer drugs to maximize the selective induction of cancer cell death. We consider this review an extensive compilation of updated known information on chemotherapy resistance mechanisms to promote new combination therapies to be to discussed and tested

Advances in Education Vol3 No1

Abstract-Interdisciplinarity may help teachers on preventing the excessive fragmentation of the scholar curriculum also approximating it from the students' life. In order to create these interdisciplinary moments, teachers need educational materials to support their professional activity. On this context, there is an urgent need for interdisciplinary materials able to help this interdisciplinary process. This article focuses on the development and implementation of an interdisciplinary multimedia material about the theme Proteins. The material was developed using an interdisciplinary way involving high school teachers of biology and chemistry. Its main purpose is to offer interdisciplinary moments not only for the students but also for the teachers involved