Citizen Hariri and neoliberal politics in postwar Lebanon

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

A new procedure for the monitoring of Cationic Detergents in solution

The paper describes a new procedure for the selective monitoring of cationic surfactants in solution. The procedure is based on the fact that cationic surfactants are accumulated inside mitochondria by a potential-driven mechanism. Once inside, the surfactant induces the release of the dye Safranine, previously accumulated inside mitochondria. Therefore the monitoring consists of a direct spectrophotometric measure of the rate of release of safranine in the resuspending medium containing the cationic surfactant

The ArDM experiment

The aim of the ArDM project is the development and operation of a one ton double-phase liquid argon detector for direct Dark Matter searches. The detector measures both the scintillation light and the ionization charge from ionizing radiation using two independent readout systems. This paper briefly describes the detector concept and presents preliminary results from the ArDM R&D program, including a 3 l prototype developed to test the charge readout system.Comment: Proceedings of the Epiphany 2010 Conference, to be published in Acta Physica Polonica

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

There is increasing evidence that oncogenic transformation modifies the metabolic program of cells. A common alteration is the upregulation of glycolysis, and efforts to target glycolytic enzymes for anticancer therapy are under way. Here, we performed a genome-wide haploid genetic screen to identify resistance mechanisms to 3-bromopyruvate (3-BrPA), a drug candidate that inhibits glycolysis in a poorly understood fashion. We identified the SLC16A1 gene product, MCT1, as the main determinant of 3-BrPA sensitivity. MCT1 is necessary and sufficient for 3-BrPA uptake by cancer cells. Additionally, SLC16A1 mRNA levels are the best predictor of 3-BrPA sensitivity and are most elevated in glycolytic cancer cells. Furthermore, forced MCT1 expression in 3-BrPA–resistant cancer cells sensitizes tumor xenografts to 3-BrPA treatment in vivo. Our results identify a potential biomarker for 3-BrPA sensitivity and provide proof of concept that the selectivity of cancer-expressed transporters can be exploited for delivering toxic molecules to tumors.National Institutes of Health (U.S.) (NIH CA103866)Jane Coffin Childs Memorial Fund for Medical Research (Fellowship)National Science Foundation (U.S.) (Fellowship)Howard Hughes Medical Institute (Investigator

Development of wavelength shifter coated reflectors for the ArDM argon dark matter detector

To optimise the design of the light readout in the ArDM 1-ton liquid argon dark matter detector, a range of reflector and WLS coating combinations were investigated in several small setups, where argon scintillation light was generated by radioactive sources in gas at normal temperature and pressure and shifted into the blue region by tetraphenyl butadiene (TPB). Various thicknesses of TPB were deposited by spraying and vacuum evaporation onto specular 3M{\small\texttrademark}-foil and diffuse Tetratex{\small\textregistered} (TTX) substrates. Light yields of each reflector and TPB coating combination were compared. Reflection coefficients of TPB coated reflectors were independently measured using a spectroradiometer in a wavelength range between 200 and 650 nm. WLS coating on the PMT window was also studied. These measurements were used to define the parameters of the light reflectors of the ArDM experiment. Fifteen large $120\times 25$ cm$^2$ TTX sheets were coated and assembled in the detector. Measurements in argon gas are reported providing good evidence of fulfilling the light collection requirements of the experiment.Comment: 21 pages, 17 figure