The need of dermatologists, psychiatrists and psychologists joint care in psychodermatology

The mind-skin connection has been studied since the nineteenth century. The last 40 years have set the development of new research areas which allowed the clarifying of how these two dimensions interact. The diseases that involve skin and mind constitute the field of psychodermatology and require that specialists in dermatology, psychiatry and psychology together and integrated take part in it, since skin, nervous system and mind are simultaneously affected. This paper aims to expose how psychodermatoses are currently conceptualized and the need of integration of these three specialties for conveniently treating the patients

Effect of preseasonal enzyme potentiated desensitisation (EPD) on plasma-IL-6 and IL-10 of grass pollen-sensitive asthmatic children.

EPD is a method of preventive immunotherapy which employs b-glucuronidase as a biological response modifier. Plasma IL-6 and IL-10 were measured before a single injection of EPD, 24 hours later and 15 days after in a group of 17 children suffering from grass pollen asthma. 17 normal untreated children were used as controls. Although the study was conducted before the grass pollen season when the allergic children were free of symptoms, their plasma IL-6 and IL-10 were significantly elevated before the injection of EPD. 24 hours after treatment the plasma IL-10 had increased significantly and there was also a slight rise in IL-6. 15 days after treatment IL-6 had fallen to normal but IL-10 was still elevated. These findings suggest antigen-specific and non-specific mechanisms by which EPD may produce clinical improvement

Granuloma blastomicótico na medula cervical: registro de um caso

Os autores apresentam um caso de blastomicose medular. O paciente apresentava síndrome de Brown-Séquard. Após a mielografia foi submetido à laminectomia cervical. Na operação foi encontrada lesão tumoral que a histologia mostrou tratar-se de um granuloma blastomicótico. O paciente foi medicado com Anfotericina B, associada à sulfametoxazol e trimetropim, assim como tratamento fisioterápico. A despeito do tratamento instituído o paciente não apresentou melhoras no que respeita à sintomatologia neurológica

Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair

Toxicogenetic