Developments of the pinned photodiode terahertz rectifier

This paper presents we presents a development of the structure of the pinned photodiode terahertz rectifier, in which the metal whisker of the antenna is separated from the semiconductor by a silane oxide layer, in order to reduce the surface defectiveness. The rectifies is the basic component of an image detection system based on the structure of actual CMOS image detectors. The structure combines a nano-antenna, fabricated on the top of a standard image sensor, the rectifier, and the readout electronics. The rectifier device proposed has vertical extension of some tenths of nanometers, can be created at the foot of the nano-whisker at the end of the terahertz antenna, above the storage well

Anthropogenic modifications to the drainage network of Rome (Italy). The case study of the Aqua Mariana

Rome is characterized by millennia of urbanization. Long lasting geomorphological investigations have allowed the geomorphological description of the city centre and the valorisation of its geomorphological heritage. In this paper the spatial change of the hydrographic network in historical times is illustrated, with some examples showing how deep has been, and still it is, the link between the historical-cultural development and the natural geomorphological and hydrological characteristics of the Roman territory. In particular, the most relevant human interventions on the drainage network, in the southern area of the city centre, have been investigated. Before the land-use modifications of Roman-age, this area was drained by the most important left tributary of the Tiber River within the city walls, the Nodicus River, more recently known as Aqua Mariana. This stream has undergone many anthropogenic modifications and diversions during the centuries, and its original path is known only downstream of the San Giovanni Basilica. According to geomorphological, archaeological and geological evidences, it is possible to hypothesize that the dimension of the pre-urbanization drainage basin, as known and reconstructed in the available literature, should have been until now underestimated

Non-steroidal anti-inflammatory drugs in cancer prevention and therapy

Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) can be regarded as an effective approach for cancer chemoprevention, as demonstrated by a bulk of clinical and experimental evidence. However, the clinical use of these drugs as chemopreventive agents is limited by many open questions about the optimal drug, dose, duration of therapy and knowledge about the mechanism(s) by which these drugs act. In particular, the recent data on cardiovascular toxicity of coxibs has posed some limitations on the use of NSAIDs for cancer chemoprevention in the general population. The situation is different in certain genetically susceptible subgroups, such as in individuals with genetic mutations associated with hereditary nonpolyposis colon cancer (HNPCC) or familiar adenomatous polyps (FAP) in whom lifetime risk increases up to 70-90% and in whom the benefit of a chemopreventive drug might justify its use even in the presence of adverse effects

Non-steroidal anti-inflammatory drugs in cancer prevention and therapy

Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) can be regarded as an effective approach for cancer chemoprevention, as demonstrated by a bulk of clinical and experimental evidence. However, the clinical use of these drugs as chemopreventive agents is limited by many open questions about the optimal drug, dose, duration of therapy and knowledge about the mechanism(s) by which these drugs act. In particular, the recent data on cardiovascular toxicity of coxibs has posed some limitations on the use of NSAIDs for cancer chemoprevention in the general population. The situation is different in certain genetically susceptible subgroups, such as in individuals with genetic mutations associated with hereditary nonpolyposis colon cancer (HNPCC) or familiar adenomatous polyps (FAP) in whom lifetime risk increases up to 70-90% and in whom the benefit of a chemopreventive drug might justify its use even in the presence of adverse effects

El clima vitícola de las regiones productoras de uvas para vinos de Argentina.

El territorio continental americano de la Argentina está situado entre las latitudes 21° 46’ S y 55° 03’ S y longitudes 53° 38’ O y 73° 34’ O (Instituto Geográfico Militar). Los principales tipos de clima de la Argentina son cuatro: cálido, templado, árido y frío. En la Figura 1A se observa que la extensión del territorio y los accidentes del relieve, principalmente la Cordillera de los Andes, determinan la existencia de variaciones climáticas en cada uno de los tipos citados (Servicio Meteorológico Nacional). En la Argentina, la vitivinicultura orientada a la producción de vinos finos se desarrolla principalmente en la zona pedemontana de la Cordillera de Los Andes desde los 22° hasta los 42° de latitud Sur

Prognostic value of vascular endothelial growth factor tumor tissue content of colorectal cancer

A longitudinal study was designed to quantify tumor tissue content of vascular endothelial growth factor (VEGF) in patients with colorectal cancer (CRC) and to evaluate its prognostic value in respect to the relapse-free and overall survivals

Prognostic value of carcinoembryonic antigen and vascular endothelial growth factor tumor tissue content in colorectal cancer

This study was designed to assess the prognostic significance of the combined measurement of vascular endothelial growth factor (VEGF) and carcinoembryonic antigen (CEA) tissue content with respect to relapse-free and overall survival of patients with colorectal cancer (CRC)

Simulations of the X-ray imaging capabilities of the Silicon Drift Detectors (SDD) for the LOFT Wide Field Monitor

The Large Observatory For X-ray Timing (LOFT), selected by ESA as one of the four Cosmic Vision M3 candidate missions to undergo an assessment phase, will revolutionize the study of compact objects in our galaxy and of the brightest supermassive black holes in active galactic nuclei. The Large Area Detector (LAD), carrying an unprecedented effective area of 10 m^2, is complemented by a coded-mask Wide Field Monitor, in charge of monitoring a large fraction of the sky potentially accessible to the LAD, to provide the history and context for the sources observed by LAD and to trigger its observations on their most interesting and extreme states. In this paper we present detailed simulations of the imaging capabilities of the Silicon Drift Detectors developed for the LOFT Wide Field Monitor detection plane. The simulations explore a large parameter space for both the detector design and the environmental conditions, allowing us to optimize the detector characteristics and demonstrating the X-ray imaging performance of the large-area SDDs in the 2-50 keV energy band.Comment: Proceedings of SPIE, Vol. 8443, Paper No. 8443-210, 201