192 research outputs found
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Enhancing quantum efficiency of thin-film silicon solar cells by Pareto optimality
We present a composite design methodology for the simulation and optimization of the solar cell performance. Our method is based on the synergy of different computational techniques and it is especially designed for the thin-film cell technology. In particular, we aim to efficiently simulate light trapping and plasmonic effects to enhance the light harvesting of the cell. The methodology is based on the sequential application of a hierarchy of approaches: (a) full Maxwell simulations are applied to derive the photon’s scattering probability in systems presenting textured interfaces; (b) calibrated Photonic Monte Carlo is used in junction with the scattering matrices method to evaluate coherent and scattered photon absorption in the full cell architectures; (c) the results of these advanced optical simulations are used as the pair generation terms in model implemented in an effective Technology Computer Aided Design tool for the derivation of the cell performance; (d) the models are investigated by qualitative and quantitative sensitivity analysis algorithms, to evaluate the importance of the design parameters considered on the models output and to get a first order descriptions of the objective space; (e) sensitivity analysis results are used to guide and simplify the optimization of the model achieved through both Single Objective Optimization (in order to fully maximize devices efficiency) and Multi Objective Optimization (in order to balance efficiency and cost); (f) Local, Global and “Glocal” robustness of optimal solutions found by the optimization algorithms are statistically evaluated; (g) data-based Identifiability Analysis is used to study the relationship between parameters. The results obtained show a noteworthy improvement with respect to the quantum efficiency of the reference cell demonstrating that the methodology presented is suitable for effective optimization of solar cell devices
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Evidence of improvement in thermoelectric parameters of n-type Bi2Te3/graphite nanocomposite
Improvement of thermoelectric parameters is reported with graphite incorporation in n-type
Bi2Te3/graphite nanocomposite system. In-depth thermoelectric properties of nanostructured
Bi2Te3/graphite composites are probed both microscopically and macroscopically using X-ray
diffraction, Raman spectroscopy, inelastic neutron scattering and measurement of the temperature
dependence of thermal conductivity , Seebeck coefficient S, resistivity ρ, and carrier concentration
nH. Raman spectroscopic analysis confirms that graphite introduces defects and disorder in the
system. Graphite addition induces a large (17%) decrease of , originating from a strong phonon
scattering effect. A low lattice thermal conductivities L, value of 0.77 Wm-1K-1, approaching the
min value, estimated using the Cahill-Pohl model, is reported for Bi2Te3+1 wt% graphite sample.
Graphite dispersion alters the low energy inelastic neutron scattering spectrum providing evidence
for modification of the Bi2Te3 Phonon Density of States (PDOS). Improvement of the other
thermoelectric parameters, viz., Seebeck Coefficient and resistivity, is also reported. Theoretical
modeling of electrical and thermal transport parameters is carried out and a plausible explanation of
the underlying transport mechanism is provided assuming a simple model of ballistic electron
transport in 1D contact channels with two different energies
The effectiveness, acceptability and cost-effectiveness of psychosocial interventions for maltreated children and adolescents: an evidence synthesis.
BACKGROUND: Child maltreatment is a substantial social problem that affects large numbers of children and young people in the UK, resulting in a range of significant short- and long-term psychosocial problems. OBJECTIVES: To synthesise evidence of the effectiveness, cost-effectiveness and acceptability of interventions addressing the adverse consequences of child maltreatment. STUDY DESIGN: For effectiveness, we included any controlled study. Other study designs were considered for economic decision modelling. For acceptability, we included any study that asked participants for their views. PARTICIPANTS: Children and young people up to 24 years 11 months, who had experienced maltreatment before the age of 17 years 11 months. INTERVENTIONS: Any psychosocial intervention provided in any setting aiming to address the consequences of maltreatment. MAIN OUTCOME MEASURES: Psychological distress [particularly post-traumatic stress disorder (PTSD), depression and anxiety, and self-harm], behaviour, social functioning, quality of life and acceptability. METHODS: Young Persons and Professional Advisory Groups guided the project, which was conducted in accordance with Cochrane Collaboration and NHS Centre for Reviews and Dissemination guidance. Departures from the published protocol were recorded and explained. Meta-analyses and cost-effectiveness analyses of available data were undertaken where possible. RESULTS: We identified 198 effectiveness studies (including 62 randomised trials); six economic evaluations (five using trial data and one decision-analytic model); and 73 studies investigating treatment acceptability. Pooled data on cognitive-behavioural therapy (CBT) for sexual abuse suggested post-treatment reductions in PTSD [standardised mean difference (SMD) -0.44 (95% CI -4.43 to -1.53)], depression [mean difference -2.83 (95% CI -4.53 to -1.13)] and anxiety [SMD -0.23 (95% CI -0.03 to -0.42)]. No differences were observed for post-treatment sexualised behaviour, externalising behaviour, behaviour management skills of parents, or parental support to the child. Findings from attachment-focused interventions suggested improvements in secure attachment [odds ratio 0.14 (95% CI 0.03 to 0.70)] and reductions in disorganised behaviour [SMD 0.23 (95% CI 0.13 to 0.42)], but no differences in avoidant attachment or externalising behaviour. Few studies addressed the role of caregivers, or the impact of the therapist-child relationship. Economic evaluations suffered methodological limitations and provided conflicting results. As a result, decision-analytic modelling was not possible, but cost-effectiveness analysis using effectiveness data from meta-analyses was undertaken for the most promising intervention: CBT for sexual abuse. Analyses of the cost-effectiveness of CBT were limited by the lack of cost data beyond the cost of CBT itself. CONCLUSIONS: It is not possible to draw firm conclusions about which interventions are effective for children with different maltreatment profiles, which are of no benefit or are harmful, and which factors encourage people to seek therapy, accept the offer of therapy and actively engage with therapy. Little is known about the cost-effectiveness of alternative interventions. LIMITATIONS: Studies were largely conducted outside the UK. The heterogeneity of outcomes and measures seriously impacted on the ability to conduct meta-analyses. FUTURE WORK: Studies are needed that assess the effectiveness of interventions within a UK context, which address the wider effects of maltreatment, as well as specific clinical outcomes. STUDY REGISTRATION: This study is registered as PROSPERO CRD42013003889. FUNDING: The National Institute for Health Research Health Technology Assessment programme
TRY plant trait database - enhanced coverage and open access
Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives
Cooperation and Competition Strategies in Multi-objective Shape Optimization - Application to Low-boom/Low-drag Supersonic Business Jet
International audienceCooperation and competition are natural laws that regulate the interactions between agents in numerous physical, or social phenomena. By analogy, we transpose these laws to devise e cient multi-objective algorithms applied to shape optimization problems involving two or more disciplines. Two e cient strategies are presented in this paper: a multiple gradient descent algorithm (MGDA) and a Nash game strategy based on an original split of territories between disciplines. MGDA is a multi-objective extension of the steepest descent method. The use of a gradient-based algorithm that exploits the cooperation principle aims at reducing the number of iterations required for classical multi-objective evolutionary algorithms to converge to a Pareto optimal design. On the other hand side, the Nash game strategy is well adapted to typical aeronautical optimization problems, when, after having optimized a preponderant or fragile discipline (e.g. aerodynamics), by the minimization of a primary objective-function, one then wishes to reduce a secondary objective-function, representative of another discipline, in a process that avoids degrading excessively the original optimum. Presently, the combination of the two approaches is exploited, in a method that explores the entire Pareto front. Both algorithms are rst analyzed on analytical test cases to demonstrate their main features and then applied to the optimum-shape design of a low-boom/low-drag supersonic business jet design problem. Indeed, sonic boom is one of the main limiting factors to the development of civil supersonic transportation. As the driving design for low-boom is not compliant with the low-drag one, our goal is to provide a trade-o between aerodynamics and acoustics. Thus Nash games are adopted to de ne a low-boom con guration close to aerodynamic optimality w.r.t. wave drag
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
Down syndrome, caused by an extra copy of chromosome 21, is associated with a greatly increased risk of early onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor protein (APP), an Alzheimer risk factor, although the possession of extra copies of other chromosome 21 genes may also play a role. Further study of the mechanisms underlying the development of Alzheimer disease in Down syndrome could provide insights into the mechanisms that cause dementia in the general population
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