Longitudinal Analysis of Peripheral and Colonic CD161+ CD4+ T Cell Dysfunction in Acute HIV-1 Infection and Effects of Early Treatment Initiation

10.3390/v12121426Viruses121

Qualidade da água de nascentes com diferentes usos do solo na bacia hidrográfica do córrego rico, São Paulo, Brasil Water quality of springs with different land uses in córrego rico watershed, São Paulo, Brazil

Com o objetivo de verificar a influência de remanescentes de vegetação ciliar e da ação antrópica na qualidade da água, estudaram-se quatro nascentes, sendo duas com a presença de vegetação natural remanescente e duas com predominância de atividades agrícolas. Essas nascentes fazem parte da bacia hidrográfica do Córrego Rico, estando localizadas nos municípios de Taquaritinga e de Guariba - SP, em duas classes de solo: Argissolo e Latossolo, respectivamente. Definiram-se pontos de coleta da água nas nascentes e ao longo dos cursos d'água (entre 0 a 50 m da nascente), em dois períodos (chuvoso e seco). Foram analisadas as seguintes variáveis: cor, pH, temperatura, turbidez, alcalinidade, dureza total, dureza em magnésio, dureza em cálcio, fósforo, nitrogênio e demanda bioquímica de oxigênio. De maneira geral, ocorreu agrupamento por nascentes e também por períodos, confirmando que os períodos de amostragem, assim como as características e diferentes usos do solo influenciam na qualidade da água das microbacias. As variáveis cor, turbidez, alcalinidade e nitrogênio total foram as que apresentaram maior importância relativa nas variáveis canônicas.<br>With the objective of verify the remainders influence of ciliary vegetation and of the human action on the water quality, four springs were studied, with two springs on presence of remaining natural vegetation and two springs with agricultural activities predominance. These springs are part of Córrego Rico watershed, being located in the municipal districts of Taquaritinga and Guariba, São Paulo State, Brazil, in two classes of soil: argisoil and latosoil, respectively. Points of collection of water were defined on the spring and along the water flow (among 0 to 50 m of the spring), in two periods (rainy and dry). The following variables were analyzed: color, pH, temperature, turbidity, alkalinity, total hardness, magnesium hardness, calcium hardness, phosphorus, nitrogen and DBO. It was concluded that, in a general way, a separation for springs and also for periods was observed, confirming that the sampling periods as well as the characteristics and different uses of the soil influence the water quality of the watersheds. Color, turbidity, alkalinity, and total nitrogen are the variables that presented the better relative importance in the canonic variables

Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams

Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive (gestation length, post-implantation loss, litter size, litter weight) and hepatic (albumin, AST, ALT, GGT) parameters. The antioxidant property of P. incarnata was evidenced both in vivo (increase in the total antioxidant plasmatic potential) and in vitro (decrease in neutrophil-induced respiratory burst). The results from the present study indicate that under the experimental conditions evaluated, P. incarnata treatment during gestation and lactation presented antioxidant activity in the absence of maternal reproductive toxicity