Strategies for cancer treatment based on photonic nanomedicine

Traditional cancer treatments, such as surgery, radiotherapy, and chemotherapy, are still the most effective clinical practice options. However, these treatments may display moderate to severe side effects caused by their low temporal or spatial resolution. In this sense, photonic nanomedicine therapies have been arising as an alternative to traditional cancer treatments since they display more control of temporal and spatial resolution, thereby yielding fewer side effects. In this work, we reviewed the challenge of current cancer treatments, using the PubMed and Web of Science database, focusing on the advances of three prominent therapies approached by photonic nanomedicine: (i) photothermal therapy; (ii) photodynamic therapy; (iii) photoresponsive drug delivery systems. These photonic nanomedicines act on the cancer cells through different mechanisms, such as hyperthermic effect and delivery of chemotherapeutics and species that cause oxidative stress. Furthermore, we covered the recent advances in materials science applied in photonic nanomedicine, highlighting the main classes of materials used in each therapy, their applications in the context of cancer treatment, as well as their advantages, limitations, and future perspectives. Finally, although some photonic nanomedicines are undergoing clinical trials, their effectiveness in cancer treatment have already been highlighted by pre-clinical studies

The Evolution of Globular Clusters in the Galaxy

We investigate the evolution of globular clusters using N-body calculations and anisotropic Fokker-Planck (FP) calculations. The models include a mass spectrum, mass loss due to stellar evolution, and the tidal field of the parent galaxy. Recent N-body calculations have revealed a serious discrepancy between the results of N-body calculations and isotropic FP calculations. The main reason for the discrepancy is an oversimplified treatment of the tidal field employed in the isotropic FP models. In this paper we perform a series of calculations with anisotropic FP models with a better treatment of the tidal boundary and compare these with N-body calculations. The new tidal boundary condition in our FP model includes one free parameter. We find that a single value of this parameter gives satisfactory agreement between the N-body and FP models over a wide range of initial conditions. Using the improved FP model, we carry out an extensive survey of the evolution of globular clusters over a wide range of initial conditions varying the slope of the mass function, the central concentration, and the relaxation time. The evolution of clusters is followed up to the moment of core collapse or the disruption of the clusters in the tidal field of the parent galaxy. In general, our model clusters, calculated with the anisotropic FP model with the improved treatment for the tidal boundary, live longer than isotropic models. The difference in the lifetime between the isotropic and anisotropic models is particularly large when the effect of mass loss via stellar evolution is rather significant. On the other hand the difference is small for relaxation- dominated clusters which initially have steep mass functions and high central concentrations.Comment: 36 pages, 11 figures, LaTeX; added figures and tables; accepted by Ap

DDO Photometry of M71: Carbon and Nitrogen Patterns Among Evolving Giants

We present V, B-V, and DDO C(41-42) and C(42-45) photometry for a sample of 75 red giants down to M_V = +2 in the relatively metal-rich Galactic globular cluster M71. The C(41-42) colors reveal a bimodal distribution of CN band strengths generally anticorrelated with CH band strength as measured by the C(42-45) color. Both DDO colors agree well with those found in 47 Tucanae -- a nearby globular cluster of similar metallicity -- and suggest nearly identical C and N abundance patterns among the giants of both clusters. A comparison with synthetic DDO colors demonstrates that little change in surface C or N abundance is required to match the colors of the M71 giants over the entire luminosity range observed. Apparently like 47 Tuc (a cluster of much greater mass and central concentration), M71 exhibits an abundance pattern which cannot be solely the result of internal mixing.Comment: To appear in the Astronomical Journal, November 2001. 17 Pages, 5 Figure

Prospecção de reguladores de crescimento para o controle de vigor em Cabernet Sauvignon (Vitis vinifera L) na Serra Gaúcha-RS.

O presente trabalho teve por objetivo caracterizar o efeito da época de aplicação de dois inibidores de giberelina, Prohexadiona de Cálcio (Viviful®, V) e Etil-trinexapac (Moddus®, M), sobre o crescimento vegetativo e produtivo da videira. Utilizou-se um vinhedo comercial de Cabernet Sauvignon/Paulsen 1103, conduzido em espaldeira e poda em cordão esporonado