Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies

<p><b>Background and Purpose:</b> Glycine Antagonist in Neuroprotection (GAIN) International and GAIN Americas trials were prospectively designed, randomized, placebo-controlled trials of gavestinel, a glycine-site antagonist and putative neuroprotectant drug administered within 6 hours of suspected ischemic or hemorrhagic stroke. Both trials reported that gavestinel was ineffective in ischemic stroke. This analysis reports the results in those with primary intracerebral hemorrhage.</p> <p><b>Methods:</b> The primary hypothesis was that gavestinel treatment did not alter outcome, measured at 3 months by the Barthel Index (BI), from acute intracerebral hemorrhage, based on pooled results from both trials. The BI scores were divided into 3 groups: 95 to 100 (independent), 60 to 90 (assisted independence), and 0 to 55 (dependent) or dead.</p> <p><b>Results:</b> In total, 3450 patients were randomized in GAIN International (N=1804) and GAIN Americas (N=1646). Of these, 571 were ultimately identified to have spontaneous intracerebral hematoma on baseline head computerized tomography scan. The difference in distribution of trichotomized BI scores at 3 months between gavestinel and placebo was not statistically significant (P=0.09). Serious adverse events were reported at similar rates in the 2 treatment groups.</p> <p><b>Conclusions:</b> These observations from the combined GAIN International and GAIN Americas trials suggest that gavestinel is not of substantial benefit or harm to patients with primary intracerebral hemorrhage. These findings are similar to results previously reported in patients with ischemic stroke.</p&gt

Operator-Algebraic Approach to the Yrast Spectrum of Weakly Interacting Trapped Bosons

We present an operator-algebraic approach to deriving the low-lying quasi-degenerate spectrum of weakly interacting trapped N bosons with total angular momentum \hbar L for the case of small L/N, demonstrating that the lowest-lying excitation spectrum is given by 27 g n_3(n_3-1)/34, where g is the strength of the repulsive contact interaction and n_3 the number of excited octupole quanta. Our method provides constraints for these quasi-degenerate many-body states and gives higher excitation energies that depend linearly on N.Comment: 7 pages, one figur

Generation and evolution of vortex-antivortex pairs in Bose-Einstein condensates

We propose a method for generating and controlling a spatially separated vortex--antivortex pair in a Bose-Einstein condensate trapped in a toroidal potential. Our simulations of the time dependent Gross-Pitaevskii equation show that in toroidal condensates vortex dynamics are different from the dynamics in the homogeneous case. Our numerical results agree well with analytical calculations using the image method. Our proposal offers an effective example of coherent generation and control of vortex dynamics in atomic condensates.Comment: 4 pages, 2 figure

Attachment Styles Within the Coach-Athlete Dyad: Preliminary Investigation and Assessment Development

The present preliminary study aimed to develop and examine the psychometric properties of a new sport-specific self-report instrument designed to assess athletes’ and coaches’ attachment styles. The development and initial validation comprised three main phases. In Phase 1, a pool of items was generated based on pre-existing self-report attachment instruments, modified to reflect a coach and an athlete’s style of attachment. In Phase 2, the content validity of the items was assessed by a panel of experts. A final scale was developed and administered to 405 coaches and 298 athletes (N = 703 participants). In Phase 3, confirmatory factor analysis of the obtained data was conducted to determine the final items of the Coach-Athlete Attachment Scale (CAAS). Confirmatory factor analysis revealed acceptable goodness of fit indexes for a 3-first order factor model as well as a 2-first order factor model for both the athlete and the coach data, respectively. A secure attachment style positively predicted relationship satisfaction, while an insecure attachment style was a negative predictor of relationship satisfaction. The CAAS revealed initial psychometric properties of content, factorial, and predictive validity, as well as reliability

Microfluidic and Nanofluidic Cavities for Quantum Fluids Experiments

The union of quantum fluids research with nanoscience is rich with opportunities for new physics. The relevant length scales in quantum fluids, 3He in particular, are comparable to those possible using microfluidic and nanofluidic devices. In this article, we will briefly review how the physics of quantum fluids depends strongly on confinement on the microscale and nanoscale. Then we present devices fabricated specifically for quantum fluids research, with cavity sizes ranging from 30 nm to 11 microns deep, and the characterization of these devices for low temperature quantum fluids experiments.Comment: 12 pages, 3 figures, Accepted to Journal of Low Temperature Physic

Vortex Rings in two Component Bose-Einstein Condensates

We study the structure of the vortex core in two-component Bose-Einstein condensates. We demonstrate that the order parameter may not vanish and the symmetry may not be restored in the core of the vortex. In this case such vortices can form vortex rings known as vortons in particle physics literature. In contrast with well-studied superfluid $^4He$, where similar vortex rings can be stable due to Magnus force only if they move, the vortex rings in two-component BECs can be stable even if they are at rest. This beautiful effect was first discussed by Witten in the cosmic string context, where it was shown that the stabilization occurs due to condensation of the second component of the field in the vortex core. This second condensate trapped in the core may carry a current along the vortex ring counteracting the effect of string tension that causes the loop to shrink. We speculate that such vortons may have been already observed in the laboratory. We also speculate that the experimental study of topological structures in BECs can provide a unique opportunity to study cosmology and astrophysics by doing laboratory experiments.Comment: 21 pages, 2 figure

Scattering of light and atoms in a Fermi-Dirac gas with BCS pairing

We theoretically study the optical properties of a Fermi-Dirac gas in the presence of a superfluid state. We calculate the leading quantum-statistical corrections to the standard column density result of the electric susceptibility. We also consider the Bragg diffraction of atoms by means of light-stimulated transitions of photons between two intersecting laser beams. Bardeen-Cooper-Schrieffer pairing between atoms in different internal levels magnifies incoherent scattering processes. The absorption linewidth of a Fermi-Dirac gas is broadened and shifted. Bardeen-Cooper-Schrieffer pairing introduces a collisional local-field shift that may dramatically dominate the Lorentz-Lorenz shift. For the case of the Bragg spectroscopy the static structure function may be significantly increased due to superfluidity in the nearforward scattering.Comment: 13 pages, 6 figures; to appear in PR

Vortex phase diagram in trapped Bose-Einstein condensation

The vortex phase diagram in the external rotation frequency versus temperature is calculated for dilute Bose-Einstein condensed gases. It is determined within the Bogoliubov-Popov theory for a finite temperature where the condensate and non-condensate fractions are treated in an equal footing. The temperature dependences of various thermodynamic instability lines for the vortex nucleation are computed to construct the phase diagram. Experiments are proposed to resolve a recent controversy on the vortex creation problem associated with the quantized vortex observation in $^{87}$Rb atom gases.Comment: 11 pages, 8 figure

Thermodynamic properties of thin films of superfluid 3He-A

The pairing correlations in superfluid He-3 are strongly modified by quasiparticle scattering off a surface or an interface. We present theoretical results and predictions for the order parameter, the quasiparticle excitation spectrum and the free energy for thin films of superfluid He-3. Both specular and diffuse scattering by a substrate are considered, while the free surface is assumed to be a perfectly reflecting specular boundary. The results are based on self-consistent calculations of the order parameter and quasiparticle excitation spectrum at zero pressure. We obtain new results for the phase diagram, free energy, entropy and specific heat of thin films of superfluid He-3.Comment: Replaced with an updated versio