Recent advances in hypertension and cardiovascular toxicities with vascular endothelial growth factor inhibition

No abstract available

The Transition to Adulthood for High School Students with Special Needs

The reason for many special needs students not engaging in occupations after high school is because many guardians have not had to navigate this type of transition before and are not provided enough education on what these opportunities include before their students graduate. Many students with special needs do not optimize their engagement in the community because guardians are not being provided with education on post-graduate opportunities. The purpose of my Doctoral Capstone Project is to develop an educational transition service program for special needs students as well as guardians and teachers of these students preparing for high school graduation and transitioning into adulthood.https://soar.usa.edu/otdcapstonesspring2024/1070/thumbnail.jp

Short-Lived Active Prorenin:Precursor of So-Called Native Prorenin

The enzymatic activity of the aspartic protease, renin, is critical for its function in blood pressure regulation and sodium homeostasis. Incubation of so-called native prorenin at low pH leads to its activation. After binding to transition-state mimicking renin inhibitors at neutral pH, prorenin attains the active conformation, as indicated by immunosorbent assay using monoclonal antibodies specific for epitopes of the prosegment or the renin body. A comparison of immunosorbent assay with enzyme-kinetic assay revealed the intermediary steps of prorenin auto-activation/inactivation. The kinetically identified intermediary steps of activation/inactivation correspond with the published crystal structures of free renin, free prorenin, and renin in complex with inhibitors. Both renin and activated prorenin exist in 2 forms, α and β. The α form is active, and the α/β quantity ratio is 2.5. The kidney produces renin and prorenin, while the ovarium, placenta, and eye produce inactive prorenin. The production of renin by these organs has never been demonstrated. We propose that the so-called native prorenin in extracellular fluid, including the circulation, is derived, at least partly, from short-lived active prorenin. Its potential paracrine function is discussed.</p