A gyomorrák kezelésének aktualitásai

Gastric cancer is the 9th most common malignancy in Hungary, being the 4th most frequent cause of death among all cancers. The traditional treatment approaches did not turn out to be effective against advanced gastric cancer. On the other hand, due to better understanding of the underlying molecular biology of tumors, targeted therapeutics emerge resulting in longer survival times. Dank M. Recent advances in the treatment of gastric cancer

A FEATHER

Featured fiction: A feather. Yes, that’s what it is. The kind of feather you see on the tail of the rooster in the chook yard...do you remember him? He’s the only rooster in that chook yard. With those handsome tail feathers, casting themselves across the dry scratched earth of his empire, in long darkened shadows. And in those shadows, did you see the twisted, naked fingers curving into the earth trying to dress themselves in the puffs of dust rising from his incessant scratching

Who’s to Blame for Shame? Interpersonal Influences on Self-Conscious Emotions in Early Adolescence

Theories of self-conscious emotional experience suggest that shame and guilt arise as a result of negative self-appraisals surrounding one’s conformity to social norms; however, shame focuses on whole-self appraisal while guilt focuses more specifically on the actions one has taken. As a result, shame tends to be associated with more negative aspects of behavior, mental health, and wellbeing. Thus, it is valuable to examine possible aspects of development that influence individuals’ tendencies toward shame or guilt. Some evidence suggests that negative parenting styles are associated with shame, and positive parenting styles with guilt. This study aims to investigate whether the parenting dimensions of responsiveness and demandingness are associated with shame-proneness and guilt-proneness in early adolescence, and whether peer social support can function as a protective factor. It is predicted that guilt-proneness will be associated with higher responsiveness and lower demandingness, while shame-proneness will be associated with lower responsiveness and higher demandingness. It is also predicted that perceived peer support will moderate the relationships between parenting styles and shame-proneness such that these relationships will be weaker for those with high social support than those with low social support. Finally, it is predicted that there will be gender differences in shame and guilt, such that females and non-binary individuals will have higher levels of both shame and guilt-proneness than males. The results of this study will expand understanding about self-conscious emotions, the impact of parenting styles on emotional development, and possible protective factors to promote beneficial outcomes in early adolescents with adverse upbringings

What is relevant in hyperthermia treatment: heat, temperature, field or something else?

There are intensive discussions in the scientific communities on the quality-parameters of hyperthermia. Most of the parties are convinced that only the temperature decides about the optimal treatment, but strong doubts are also exists declaring the delivered heat (absorbed energy) or applied field (electro-magnetic influence) as primary effects. Strong points of the temperature-supporters are the results of all the investigations which are concentrating on the temperature-dependence and the effectivity of Arrhenius analysis showing a phase transition at about 42.5 C, (this is the basic of the step-down heating). On the other hand no doubts about the strong heat-dose dependence, which is most trivial by the treatment-time relevance in the clinical and laboratory results. The field effects in the hyperthermia does not investigated so widely, but trivial questions arise to choose the techniques, different applicators, frequencies and couplings. We had developed a set of the hyperthermia treatments applying various mixes of the heat and field effects. Four methods are applied successfully, where the heat- and field-effects are involved by different ratio for various malignant cases. Among the four methods there are a method with only electric field application (ECT, percutane, no heat), moderate heat with moderate field (PCT, cavitational), dominate local heat and electric field (EHY, loco-regional) and almost no field, only heat (WBH, whole-body application). The reached temperature in the tissue does not determined only by the absorbed heat, physically other effects have decisional role in the measured temperature. The applied power in the various methods is very different, ranging from a few watts to the few kW, while the electric field ranges from a few tens [mV/cell] to the few [nV/cell]. Due to the large and essential inhomogenities of the well-developed tumors only the average temperature could be defined in most of the cases. Same average temperature is reachable by different applied power, only depending on the power-delivery conditions. This observation strongly supports the importance of the heat (energy) absorption [W/kg] in the tumor instead of the only temperature conception. Results show the excellence of the optimizing the method to the actual case. With all the four treatment modalities we have surprisingly good results by choosing the most optimal for the given case and combining the applied methods with each other. Results by the different electro-hyperthermia applications will be shown in the presentation. The loco-regional applications are massively applied in deep-organ treatments (pancreas, liver, brain, etc.), while the cavitational is devoted for prostate, bladder and gynecological, etc. cases. The percutane local treatment is very effective for mammary-carcinomas, for head- and neck-cases, malignant melanomas, etc. The IR-A radiative whole-body hyperthermia is very useful in metastasizes, in systematic cases, etc. According to the intensive laboratory and clinical experiences and strong evidences we can conclude, that beside the temperature the heat-delivery as well as the field effects are primary important for the oncological hyperthermia

Estimating the Size and Structure of the Underground Commercial Sex Economy in Eight Major U.S. Cities

The underground commercial sex economy (UCSE) generates millions of dollars annually, yet investigation and data collection remain under resourced. Our study aimed to unveil the scale of the UCSE in eight major US cities. Across cities, the UCSE's worth was estimated between $39.9 and$290 million in 2007, but decreased since 2003 in all but two cities. Interviews with pimps, traffickers, sex workers, child pornographers, and law enforcement revealed the dynamics central to the underground commercial sex trade -- and shaped the policy suggestions to combat it

Understanding the Organization, Operation, and Victimization Process of Labor Trafficking in the United States

This study examines the organization, operation, and victimization process of labor trafficking across multiple industries in the United States. It examines labor trafficking victim abuse and exploitation along a continuum, from victims' recruitment for work in the United States; through their migration experiences (if any), employment victimization experiences, and efforts to seek help; to their ultimate escape and receipt of services. Data for this study came from a sample of 122 closed labor trafficking victim service records from service providers in four US cities. In addition, interviews were conducted with labor trafficking survivors, local and federal law enforcement officials, legal advocates, and service providers in each site to better understand the labor trafficking victimization experience, the networks involved in labor trafficking and the escape and removal process, and the barriers to investigation and prosecution of labor trafficking cases

William Bolcom’s Twelve New Etudes (1988): Theoretical and Interpretative Analysis

Ever since its naissance, composer William Bolcom’s set of Twelve New Etudes has garnered great critical praise, culminating with the prestigious Pulitzer Prize in 1988. Although much has been written about the background surrounding the creation of these pieces and their technical novelty, no formal analysis of this set of etudes has been published. This dissertation thoroughly examines the various aspects which hold these pieces together. Each etude is analyzed according to a clearly defined set of criteria: dynamics, compositional language, range, texture, articulation and contour, meter and rhythm, and form. In addition, a more detailed analysis is offered, providing an analytical and descriptive musical narrative of the piece. The analysis is predicated upon a few assumptions, which the author sets to argue and prove throughout the document. First, is the idea that although Bolcom is boldly experimental through these compositions, his modus operandi is to leave a few stabilizing elements in each piece. The choice of with which elements to experiment, and which to stabilize, changes from etude to etude, and is partly responsible for the great variety in the set. Second, is the assumption that Bolcom’s background as a concert pianist greatly informs and guides his musical decisions. This is particularly noticeable through the palpable use of hand positions in his passagework. Lastly, is the assumption that Bolcom’s immensely varied background as a composer, ranging from the application of serial techniques in his early works, to his working knowledge of jazz theory, is responsible for his unique compositional language

Technology and Labor Trafficking: in a Network Society - General Overview, Emerging Innovations, and Phillippines Case Study

New information and communication technologies (ICTs) have become an integral part of the networks that underpin labor trafficking in the 21st Century. Yet little research exists on the impact of technology in exacerbating or addressing the isolation, fraud, force, and/or coercion so often at the heart of trafficking cases. There is a lack of evidence-based research on any relationship between technology and labor trafficking either within or across national borders. To effectively intervene in labor trafficking, the impact of technology needs to be addressed by policy makers, governments, NGOs, researchers, and the private sector.This research report is the first to investigate the relationship between technology and labor trafficking. The evidence gathered and analyzed in this report is based on public documents, websites, interviews with key stakeholders in the US and internationally, and fieldwork in the Philippines. With little previous research on the topic, this study is inherently exploratory. Thus this report's primary goal is to frame technology's impact on labor trafficking and to establish a set of definitions, theories, terms, themes, recommendations, and principles that can guide future research and policy