Managing erosion of mangrove-mud coasts with permeable dams – lessons learned

Mangrove-mud coasts across the world erode because of uninformed management, conversion of mangrove forests into aquaculture ponds, development of infrastructure and urbanization, and/or extraction of groundwater inducing land subsidence. The accompanied loss of ecosystem values, amongst which safety against flooding, has far reaching consequences for coastal communities, exacerbated by sea-level rise. To halt erosion various nature-based solutions have been implemented as an alternative to hard infrastructure sea defenses, including mangrove planting and erection of low-tech structures such as bamboo fences, permeable brushwood dams, etc. These structures have been designed on the basis of best-engineering practice, lacking sufficient scientific background. This paper investigates the use and success of permeable dams over a period of about 15 years, describing their application in Guyana, Indonesia, Suriname, Thailand and Vietnam, summarizing the lessons-learned, and analyzing their functioning in relation to the physical-biological coastal system. Also an overview of relevant costs is given. The basic philosophy behind the construction of permeable dams is the rehabilitation of mangrove habitat through re-establishment of the (fine) sediment dynamics – we refer to Building with Nature as the overarching principle of this approach. Our main conclusions are that a successful functioning of permeable dams requires (1) a thorough understanding of the physical-biological system and analysis of the relevant processes, (2) patience and persistence, including maintenance, as the natural time scales to rehabilitate mangrove green belts take years to decades, and (3) intensive stakeholder involvement. We give a list of conditions under which permeable dams may be successful, but in qualitative terms, as local site conditions largely govern their success or failure.Environmental Fluid Mechanic

Androgen dependent stimulation of aromatase activity in genital skin fibroblasts from normals and patients with androgen insensitivity

objective To measure the effect of androgens or aromatase activity as an index of androgen responsiveness in patients with androgen insensitivity design Genital skin fibroblasts were established in culture using primary skin explants obtained from normal males at the time of circumcision and from androgen insensitive patients who had surgery either for gonadectomy (complete androgen insensitivity syndrome) or for reconstruction of the external genitalia (partial androgen insensitivity syndrome) patients Foreskin samples were obtained at the time of circumcision in 27 normal males. Scrotal or labla majora skin was obtained at the time of surgery from 14 patients with the complete and 22 with the partial forms of the androgen insensitivity syndrome measurements Basal and stimulated levels of aromatase activity were measured in genital skin fibroblasts following preincubation with natural and synthetic, non-metabolizable androgens results Following a 48-hour preincubation with testosterone or dihydrotestosterone, there was a five to six-fold stimulation of aromatase activity in normal fibroblasts. Mibolerone, a synthetic androgen, produced similar results. The stimulatory effect was blocked by anti-androgens. Seven patients with partial androgen insensitivity, of whom four were either receptor deficient or showed a qualitative defect in androgen binding, had reduced mibolerone induced stimulation of aromatase activity. All ten patients with receptor negative complete androgen insensitivity had an absent response. There was no aromatase induction in a further three patients with complete androgen insensitivity who were receptor positive. Two siblings in the latter group had an exon deletion encoding for part of the DNA binding domain of the androgen receptor conclusions Androgens stimulate aromatase activity in genital skin fibroblasts from normals. The response is mediated via the androgen receptor and can be decreased or absent in patients with the androgen insensitivity syndrome. This may be a useful in-vitro marker of androgen responsiveness in such patient