17 research outputs found
Neurobiology of sleep apnea: Implication for therapy?
An accumulating body of evidence from animal investigations supports the potential importance of vagal afferent pathways in the pathogenesis and/or therapy of SRBD. The neurochemistry and neuropharmacology of this pathway offers numerous possible targets for pharmacologic modulation. Defining the ultimate clinical relevance of these pathways in SRBD pathogenesis and treatment can only be accomplished with significant ongoing clinical and basic investigation.ZnaÄajan napredak u naÅ”em razumevanju poremeÄaja disanja u vezi sa spavanjem (SRBD) je naÄinjen u pogledu epidemiologije i faktora rizika, patogeneze i kliniÄkih i bihevioralnih posledica. Ipak, napori da se ovi faktori shvate u smislu Äelijskih, molekularnih i neuromodulatornih procesa joÅ” uvek su u povoju, Å”to nas spreÄava da razvijemo delotvorne a prihvatljive strategije dijagnostike i leÄenja. SRBD sa prevalencom od ~2% kod žena i ~4% kod muÅ”karaca [1] poveÄava rizik za kardiovaskularni, metaboliÄki i bihevioralni morbiditet [2]. Bolesnici sa SRBD mogu imati Äitav spektar respiratornih poremeÄaja tokom spavanja kao Å”to su centralna apneja (prestanak respiratornog napora); opstruktivna apneja (inspiratorni napor protiv okludiranog gornjeg disajnog puta); meÅ”ovita apneja (prikazuje se inicijalnom centralnom komponentom kojoj neposredno sledi opstruktivna komponenta); hipopneja (parcijalni kolaps gornjih disajnih puteva); i razbuÄivanja povezana sa respiratornim dogaÄajem (otežan inspiratorni napor koji dovodi do razbuÄivanja). Premda uÄestalost poremeÄaja disanja ili 'indeksa respiratornog poremeÄaja' (RDI) retko premaÅ”uje pet dogaÄaja na sat kod zdravih, do sada nije ustanovljen jasan prag RDI iznad koga nastaje bihevioralna ili kliniÄka bolest.nul
Neurobiology of sleep apnea: Implication for therapy?
An accumulating body of evidence from animal investigations supports the potential importance of vagal afferent pathways in the pathogenesis and/or therapy of SRBD. The neurochemistry and neuropharmacology of this pathway offers numerous possible targets for pharmacologic modulation. Defining the ultimate clinical relevance of these pathways in SRBD pathogenesis and treatment can only be accomplished with significant ongoing clinical and basic investigation.ZnaÄajan napredak u naÅ”em razumevanju poremeÄaja disanja u vezi sa spavanjem (SRBD) je naÄinjen u pogledu epidemiologije i faktora rizika, patogeneze i kliniÄkih i bihevioralnih posledica. Ipak, napori da se ovi faktori shvate u smislu Äelijskih, molekularnih i neuromodulatornih procesa joÅ” uvek su u povoju, Å”to nas spreÄava da razvijemo delotvorne a prihvatljive strategije dijagnostike i leÄenja. SRBD sa prevalencom od ~2% kod žena i ~4% kod muÅ”karaca [1] poveÄava rizik za kardiovaskularni, metaboliÄki i bihevioralni morbiditet [2]. Bolesnici sa SRBD mogu imati Äitav spektar respiratornih poremeÄaja tokom spavanja kao Å”to su centralna apneja (prestanak respiratornog napora); opstruktivna apneja (inspiratorni napor protiv okludiranog gornjeg disajnog puta); meÅ”ovita apneja (prikazuje se inicijalnom centralnom komponentom kojoj neposredno sledi opstruktivna komponenta); hipopneja (parcijalni kolaps gornjih disajnih puteva); i razbuÄivanja povezana sa respiratornim dogaÄajem (otežan inspiratorni napor koji dovodi do razbuÄivanja). Premda uÄestalost poremeÄaja disanja ili 'indeksa respiratornog poremeÄaja' (RDI) retko premaÅ”uje pet dogaÄaja na sat kod zdravih, do sada nije ustanovljen jasan prag RDI iznad koga nastaje bihevioralna ili kliniÄka bolest.nul
Physiological role of ITR in reflex and sleep apneas
This study demonstrates that unilateral excitotoxic lesionin of thepontine ITR increases the frequency of spontaneous central sleep apneas in freely behaving rats without alteration in average respiratory rate, minute ventilation, or sleep architecture. Thus, our findings suggest that the ITR may function specifically to dampen respiratory perturbations and that bilateral integrity of this structure is important. We may also speculate that the ITR functions to maintain stable breathing during sleep in man.nul
Physiological role of ITR in reflex and sleep apneas
This study demonstrates that unilateral excitotoxic lesionin of thepontine ITR increases the frequency of spontaneous central sleep apneas in freely behaving rats without alteration in average respiratory rate, minute ventilation, or sleep architecture. Thus, our findings suggest that the ITR may function specifically to dampen respiratory perturbations and that bilateral integrity of this structure is important. We may also speculate that the ITR functions to maintain stable breathing during sleep in man.nul
Effects of Systemic Administration of Mirtazapine on Respiratory Muscle Activity in Sleeping Rats
Modality analysis: a semantic grammar for imputations of intentionality in texts
Text analysis, Semantic grammar, Culture, Arab, Hindi, Discourse,