Some costing terms and costing approaches

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Predicting Chemical Carcinogenesis Using Structural Information Only

This paper reports on the application of the Strongly Typed Evolutionary Programming System #STEPS# to the PTE2 challenge, which consists of predicting the carcinogenic activityofchemical compounds from their molecular structure and the outcomes of a number of laboratory analyses. Most contestants so far have relied heavily on results of short term toxicity #STT# assays. Using both types of information made available, most models incorporate attributes that make them strongly dependentonSTT results. Although such models may prove to be accurate and informative, the use of toxicological information requires time cost and in some cases substantial utilisation of laboratory animals. If toxicological information only makes explicit, properties implicit in the molecular structure of chemicals, then provided a su#ciently expressive representation language, accurate solutions may be obtained from the structural information only. Such solutions may o#er more tangible insightinto the mechanistic paths and features that govern chemical toxicityaswell as prediction based on virtual chemistry for the universe of compounds

Torbay Hospital Construction and performance of the solar water heating system on the catering complex

SIGLEAvailable from British Library Lending Division - LD:3816.4705(ETSU-S--1080) / BLDSC - British Library Document Supply CentreGBUnited Kingdo