9 research outputs found
Microsomal lipid peroxidation as a mechanism of cellular damage. [Dissertation]
No full textThe NADPH/iron-dependent peroxidation of lipids in rat liver microsomes was found to be dependent on the presence of free ferrous ion and maintains iron in the reduced Fe/sup 2 +/ state. Chelation of iron by EDTA inhibited peroxidation. Addition of iron, after preincubation of microsomes in the absence of iron, did not enhance the rate of peroxidation suggesting that iron acts by initiating peroxidative decomposition of membrane lipids rather than by catalyzing the breakdown of pre-formed hydroperoxides. Liposomes also underwent peroxidation in the presence of ferrous iron at a rate comparable to intact microsomes and was stimulated by ascorbate. Carbon tetrachloride initiated lipid peroxidation in the absence of free metal ions. Rates of in vitro lipid peroxidation of microsomes and homogenates were found to vary widely between different tissues and species. The effects of paraquat on lipid peroxidation was also studied. (DC
Effects of pretreatment with inducers of hepatic mixed function oxidases on DNA repair elicited by various compounds in hepatocytes from adult and neonatal rats
No full textChanges in tissue ?-tocopherol status and degree of lipid peroxidation with varying ?-tocopheryl acetate inclusion in diets for the African catfish
No full textEthanol and food deprivation induced enhancement of hepatotoxicity in rats given carbon tetrachloride at low concentration.
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Effects of hyperoxia and diet on murine tissue levels of vitamin E and polyunsaturated fatty acids
No full textSpecies differences in lipid peroxide levels in lung tissue and investigation of their determining factors
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