Evidence that stimulation of gluconeogenesis by fatty acid is mediated through thermodynamic mechanisms

AbstractWe have studied the stimulatory effects of palmitate on the rate of glucose synthesis from lactate in isolated hepatocytes. Control of the metabolic flow was achieved by modulating the activity of enolase using graded concentrations of fluoride. Unexpectedly, palmitate stimulated gluconeogenesis even when enolase was rate-limiting. This stimulation was also observed when the activities of phosphoenolpyruvate carboxykinase and aspartate aminotransferase were modulated using graded concentrations of quinolinate and aminooxyacetate, respectively. Linear force-flow relationships were found between the rate of gluconeogenesis and indicators of cellular energy status (i.e. mitochondrial membrane and redox potentials and cellular phosphorylation potential). These findings suggest that the fatty acid stimulation of glucose synthesis is in part mediated through thermodynamic mechanisms

Active Vibration Isolation of Multi-Degree-of-Freedom Systems

One of the principal objectives of vibration isolation technology is to isolate sensitive equipment from a vibrating structure or to isolate the structure from an uncertain exogenous disturbance source. In this paper, a dynamic observer-based active isolator is proposed that guarantees closed-loop asymptotic stabil ity and disturbance decoupling between the vibrating structure and isolated structure. The proposed active isolator is applied to a uniaxial vibrational system and compared to an optimal linear-quadratic design.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69073/2/10.1177_107754639900500405.pd

Radiation induced oscillatory Hall effect in high mobility GaAs/AlGaAs devices

We examine the radiation induced modification of the Hall effect in high mobility GaAs/AlGaAs devices that exhibit vanishing resistance under microwave excitation. The modification in the Hall effect upon irradiation is characterized by (a) a small reduction in the slope of the Hall resistance curve with respect to the dark value, (b) a periodic reduction in the magnitude of the Hall resistance, $R_{xy}$, that correlates with an increase in the diagonal resistance, $R_{xx}$, and (c) a Hall resistance correction that disappears as the diagonal resistance vanishes.Comment: 4 pages text, 4 color figure

Is weak temperature dependence of electron dephasing possible?

The first-principle theory of electron dephasing by disorder-induced two state fluctuators is developed. There exist two mechanisms of dephasing. First, dephasing occurs due to direct transitions between the defect levels caused by inelastic electron-defect scattering. The second mechanism is due to violation of the time reversal symmetry caused by time-dependent fluctuations of the scattering potential. These fluctuations originate from an interaction between the dynamic defects and conduction electrons forming a thermal bath. The first contribution to the dephasing rate saturates as temperature decreases. The second contribution does not saturate, although its temperature dependence is rather weak, $\propto T^{1/3}$. The quantitative estimates based on the experimental data show that these mechanisms considered can explain the weak temperature dependence of the dephasing rate in some temperature interval. However, below some temperature dependent on the model of dynamic defects the dephasing rate tends rapidly to zero. The relation to earlier studies of the dephasing caused by the dynamical defects is discussed.Comment: 14 pages, 6 figures, submitted to PR

Quality of online self-management resources for adults living with primary brain cancer, and their carers: a systematic environmental scan

Background: A primary brain cancer diagnosis is a distressing, life changing event. It adversely affects the quality of life for the person living with brain cancer and their families (‘carers’). Timely access to evidence-based information is critical to enabling people living with brain cancer, and their carers, to self-manage the devastating impacts of this disease. Method: A systematic environmental scan of web-based resources. A depersonalised search for online English-language resources published from 2009 to December 2019 and designed for adults (> 25 years of age), living with primary brain cancer, was undertaken using the Google search engine. The online information was classified according to: 1) the step on the cancer care continuum; 2) self-management domains (PRISMS taxonomy); 3) basic information disclosure (Silberg criteria); 4) independent quality verification (HonCode); 5) reliability of disease and treatment information (DISCERN Sections 1 and 2); and readability (Flesch-Kincaid reading grade). Results: A total of 119 online resources were identified, most originating in England (n = 49); Australia (n = 27); or the USA (n = 27). The majority of resources related to active treatment (n = 76), without addressing recurrence (n = 3), survivorship (n = 1) or palliative care needs (n = 13). Few online resources directly provided self-management advice for adults living with brain cancer or their carers. Just over a fifth (n = 26, 22%) were underpinned by verifiable evidence. Only one quarter of organisations producing resources were HonCode certified (n = 9, 24%). The median resource reliability as measured by Section 1, DISCERN tool, was 56%. A median of 8.8 years of education was required to understand these online resources. Conclusions: More targeted online information is needed to provide people affected by brain cancer with practical self-management advice. Resources need to better address patient and carer needs related to: rehabilitation, managing behavioural changes, survivorship and living with uncertainty; recurrence; and transition to palliative care. Developing online resources that don’t require a high level of literacy and/or cognition are also required

Perceptual Pluralism

Perceptual systems respond to proximal stimuli by forming mental representations of distal stimuli. A central goal for the philosophy of perception is to characterize the representations delivered by perceptual systems. It may be that all perceptual representations are in some way proprietarily perceptual and differ from the representational format of thought (Dretske 1981; Carey 2009; Burge 2010; Block ms.). Or it may instead be that perception and cognition always trade in the same code (Prinz 2002; Pylyshyn 2003). This paper rejects both approaches in favor of perceptual pluralism, the thesis that perception delivers a multiplicity of representational formats, some proprietary and some shared with cognition. The argument for perceptual pluralism marshals a wide array of empirical evidence in favor of iconic (i.e., image-like, analog) representations in perception as well as discursive (i.e., language-like, digital) perceptual object representations

Spontaneous symmetry breaking in gauge theories via Bose-Einstein condensation

We propose a mechanism naturally leading to the spontaneous symmetry breaking in a gauge theory. The Higgs field is assumed to have global and gauged internal symmetries. We associate a non zero chemical potential to one of the globally conserved charges commuting with all of the gauge transformations. This induces a negative mass squared for the Higgs field triggering the spontaneous symmetry breaking of the global and local symmetries. The mechanism is general and we test the idea for the electroweak theory in which the Higgs sector is extended to possess an extra global Abelian symmetry. To this symmetry we associate a non zero chemical potential. The Bose-Einstein condensation of the Higgs leads, at tree level, to modified dispersion relations for the Higgs field while the dispersion relations of the gauge bosons and fermions remain undisturbed. The latter are modified through higher order corrections. We have computed some corrections to the vacuum polarizations of the gauge bosons and fermions. To quantify the corrections to the gauge boson vacuum polarizations with respect to the Standard Model we considered the effects on the T parameter. We finally derive the one loop modified fermion dispersion relations.Comment: RevTeX 4, 13 pages. Added references and corrected typo

An Anatomy of Price Dynamics in Illiquid Markets: Analysis and Evidence from Local Housing Markets

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73407/1/j.1080-8620.2004.00082.x.pd

Quantum Disordered Regime and Spin Gap in the Cuprate Superconductors

We discuss the crossover from the quantum critical, $z\!=\!1$, to the quantum disordered regime in high-T$_c$ materials in relation to the experimental data on the nuclear relaxation, bulk susceptibility, and inelastic neutron scattering. In our scenario, the spin excitations develop a gap $\Delta\!\sim\!1/\xi$ well above T$_c$, which is supplemented by the quasiparticle gap below T$_c$. The above experiments yield consistent estimates for the value of the spin gap, which increases as the correlation length decreases.Comment: 14 pages, REVTeX v3.0, PostScript file for 3 figures is attached, UIUC-P-93-07-06